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(11)

EP 4 824 277 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904905.7 (22) Date of filing: 12.12.2024

(51) International Patent Classification (IPC):  C12Q 1/6806(2018.01) C12Q 1/6858(2018.01) G16B 20/20(2019.01) (52) Cooperative Patent Classification (CPC): G16B 20/20; G16B 30/00; G16B 30/10; C12Q 1/6886; C12Q 2600/154 (86) International application number: PCT/US2024/059877 (87) International publication number: WO 2025/128887 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.12.2023 US 202363609810 P (71) Applicant: Foundation Medicine, Inc. Boston, MA 02210 (US)	(72) Inventors: WANG, Yexun Boston, Massachusetts 02210 (US) LAMBERT, Nicole Boston, Massachusetts 02210 (US) TANG, Qin Boston, Massachusetts 02210 (US) SUN, Yu Boston, Massachusetts 02210 (US) (74) Representative: CMS Cameron McKenna Nabarro Olswang LLP  Cannon Place 78 Cannon Street London EC4N 6AF London EC4N 6AF (GB)