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(11)

EP 4 824 287 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904900.8 (22) Date of filing: 12.12.2024

(51) International Patent Classification (IPC):  C12Q 1/6886(2018.01) C07K 16/30(2006.01) (52) Cooperative Patent Classification (CPC): C12Q 1/6886; C07K 16/2875; A61K 40/4232; A61K 40/11; A61K 40/31; A61K 31/519; A61K 31/517; A61K 31/4545; A61K 31/675; A61K 45/06; A61K 47/68031; A61K 47/6851; C12Q 2600/106; C12Q 2600/158; C12Q 2600/156   C-Sets: A61K 31/519, A61K 2300/00; A61K 31/517, A61K 2300/00; A61K 31/4545, A61K 2300/00; A61K 31/675, A61K 2300/00; (86) International application number: PCT/US2024/059869 (87) International publication number: WO 2025/128880 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.12.2023 US 202363610941 P (71) Applicant: Board of Regents, The University of Texas System Austin, TX 78701 (US)	(72) Inventors: HEYMACH, John Victor Austin, Texas 78701 (US) NILSSON, Monique B. Austin, Texas 78701 (US) (74) Representative: Atkins, James Gordon John et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)