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EP 4 824 526 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24841352.8 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  G01N 15/0205(2024.01) G01N 21/01(2006.01) G01N 15/00(2024.01) G01N 15/075(2024.01) G01N 21/51(2006.01) (52) Cooperative Patent Classification (CPC): G01N 15/0211; G01N 2015/0053; G01N 2015/0238; G01N 15/075 (86) International application number: PCT/US2024/060101 (87) International publication number: WO 2025/129044 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.12.2023 US 202363610811 P (71) Applicants: Amgen Inc. Thousand Oaks, California 91320-1799 (US) California Institute of Technology Pasadena, CA 91125 (US)

(72) Inventors: LIANG, Mingshu Pasadena, California 91125 (US) YANG, Changhuei Pasadena, California 91125 (US) CAO, Xingxiang Thousand Oaks, California 91320-1799 (US) (74) Representative: Grünecker Patent- und Rechtsanwälte PartG mbB  Leopoldstraße 4 80802 München 80802 München (DE)