(19)

(11)

EP 4 824 554 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24850282.5 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  G01N 33/68(2006.01) C07K 16/46(2006.01) C07K 16/00(2006.01) G16B 15/00(2019.01) (52) Cooperative Patent Classification (CPC): G01N 33/6803; G01N 33/6854; C07K 2317/55; C07K 2317/94; G16B 15/00; C07K 16/2887; C07K 16/28; C07K 16/40; C07K 2317/92; C07K 2317/24 (86) International application number: PCT/US2024/060051 (87) International publication number: WO 2025/129010 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.12.2023 US 202363610212 P (71) Applicant: GENENTECH, INC. South San Francisco, CA 94080 (US)	(72) Inventors: KUNG, Jennifer, Elaine San Francisco, CA 94080-4990 (US) SUDHAMSU, Jawahar San Francisco, CA 94080-4990 (US) (74) Representative: Küng, Peter  F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)