(19)
(11) EP 0 000 972 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
21.03.1979 Bulletin 1979/06

(43) Date of publication A2:
07.03.1979 Bulletin 1979/05

(21) Application number: 78200153

(22) Date of filing: 23.08.1978
(84) Designated Contracting States:
BE CH DE FR GB NL SE

(30) Priority: 29.08.1977 US 828355

(71) Applicant: Technobiotic Ltd.
 ()

(72) Inventors:
  • Steinman, Martin
     ()
  • Tahbaz, Pirouz
     ()

   


(54) 2-Substituted-3-phenylindoles, their preparation, and pharmaceutical compositions containing them


(57) The invention relates to novel 3-phenyl-indoles of the formula

wherein X and Y are independently hydrogen or halogen atoms;

each n is 1, 2 or 3,

Q is an oxygen atom or the group (H,OH),

Z is a hydrogen atom, or provided that Q is an oxygen atom, Z can also be the group OR, wherein R is a hydrogen atom or a lower alkyl or loweralkoxy-loweralkyl group, "lower" indicating groups with 1-6 carbon atoms,

m is 1 or 2 when Z is a hydrogen atom and m is O when Z is the group OR,

to their preparation, and to pharmaceutical compositions containing them. These compounds have immunosuppressant activity and can be used for example in the treatment of rheumatoid arthritis.





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