(19)
(11) EP 0 294 025 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
08.11.1989 Bulletin 1989/45

(43) Date of publication A2:
07.12.1988 Bulletin 1988/49

(21) Application number: 88303796.2

(22) Date of filing: 27.04.1988
(51) International Patent Classification (IPC)4: C07K 14/745, C12N 15/12, C12P 21/02, C12P 21/00, C07K 1/22
// A61K35/16
(84) Designated Contracting States:
AT BE CH DE ES FR GB GR IT LI LU NL SE

(30) Priority: 01.05.1987 US 45032

(71) Applicant: THE SCRIPPS RESEARCH INSTITUTE
La Jolla, CA 92037 (US)

(72) Inventors:
  • Zimmerman, Theodore S.
    La Jolla California 92037 (US)
  • Fulcher, Carol A.
    La Jolla California 92037 (US)
  • Foster, Paul A.
    San Diego California 92126 (US)

(74) Representative: Jump, Timothy John Simon et al
Venner Shipley & Co. 20 Little Britain
London EC1A 7DH
London EC1A 7DH (GB)


(56) References cited: : 
   
     
    Remarks:
    The title of the invention has been amended (Guidelines for Examination in the EPO, A-III, 7.3).
     


    (54) Peptides corresponding to the Factor VIII binding domain of the von Willebrand factor


    (57) Peptides which inhibit the binding of von Willebrand Factor to Factor VIII. Monoclonal antibodies capable of specifically binding to the region of von Willebrand Factor containing the Factor VIII binding domain. Improved methods of preparing Factor VIII.





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