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(11) | EP 0 557 129 B1 |
| (12) | EUROPEAN PATENT SPECIFICATION |
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| (54) |
Product for assisting a smoker in giving-up the habit Erzeugnis zur Unterstützung für das Aufgeben des Rauchens Produit pour assister un fumeur à cesser cet habitude |
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| Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention). |
FIELD OF THE INVENTION
BACKGROUND TO THE INVENTION
[0002] Cigarette smoke contains a large number of very complex substances the most important of which is nicotine, this being the substance to which cigarette smokers develop an addiction. Upon a cigarette smoker ceasing to smoke, withdrawal symptoms and a craving for a cigarette occur which result from the body's need for nicotine. To alleviate the effect of these withdrawal symptoms and the craving for a cigarette it has been proposed that the person attempting to break the smoking habit should be given decreasing doses of nicotine. This enables the nicotine level in the body to be reduced over a period of time which results in the withdrawal symptoms being less severe. Chewing gum with nicotine in it and tablets containing nicotine have been marketed. More recently pads which are applied to the skin have become available. Pads of various sizes are provided, the pads containing nicotine. The nicotine is absorbed steadily through the skin. The concept is that a large pad is used initially when the person attempting to give-up the smoking habit requires a high level of nicotine in his or her body to prevent withdrawal symptoms. Pads of progressively decreasing size are used as the body becomes less dependant on nicotine. In this regard reference is made to US patent 4920989 which discloses such pads.
[0003] The concept of inhaling nicotine from an aerosol device is also known and reference can be made to US Patents 4813437 and 4945929. The purpose of such devices is to provide the user with the nicotine that his or her body requires without smoke, tars and other harmful substances found in cigarettes simultaneously being inhaled. Thus the known aerosol products are substitutes for cigarettes and do not assist a smoker in ridding himself or herself of nicotine addiction. Nicotine addition is the main reason why giving up the smoking habit is so difficult.
OBJECT OF THE INVENTION
[0004] The object of the present invention is to provide an efficacious product for assisting a person in giving-up the smoking habit.
BRIEF SUMMARY OF THE INVENTION
[0005] According to the present invention there is provided a plurality of containers each of which, apart from one, contains nicotine in liquid form dispersed in at least one pharmaceutically acceptable carrier, the percentage of nicotine by volume in each container being different to the percentage of nicotine in each other container, and said one container having therein said pharmaceutically acceptable carrier but no nicotine.
[0007] There should be at least three containers, two containers having nicotine therein with the percentage of nicotine in one of these containers being greater than the percentage of nicotine in the other of these containers, the third container containing said pharmaceutically acceptable carrier but no nicotine.
[0008] It is preferred that there be four containers, three containers having nicotine therein with the percentage of nicotine in each of these containers being different to the percentage in each of the others of these three containers, the fourth container having therein at least one pharmaceutically acceptable carrier but no nicotine.
[0009] The containers can contain about 1,5%, about 1,0%, about 0,5% and 0,0% by volume nicotine. By way of example, the percentage of nicotine in the three containers can be 1,45%, 0,97% and 0,48%. Experimentation has shown that four containers containing these volumes of nicotine provides a suitable treatment for a person smoking about 30 cigarettes per day.
[0010] The containers are preferably pump operated aerosol cans so that depressing the plunger once dispenses a predetermined volume of liquid from the can. This minimises the risk that the person may receive too heavy a dose which can occur if an aerosol can of the type which contains a propellant under pressure is used.
[0011] Suitable pharmaceutically acceptable liquid carriers are alcohol, glycerine, saccharine and a flavouring such as peppermint. The alcohol can occupy the greatest volume eg from 75% to 85%, the volume of alcohol increasing as the percentage of nicotine decreases. There can be between 10- and 20% glycerine, the volume of glycerine increasing as the volume of nicotine decreases. The peppermint flavour can be about 4% by volume and the saccharine a trace eg 0.1% by volume.
DETAILED DESCRIPTION OF THE INVENTION
[0012] The following table sets out the ingredients of four cans each having a volume of 20ml and the nicotine content of which ranges from 1.45% to 0% and which is suitable for the treatment, over a period of about 1 month, of a person who at the beginning of treatment is smoking about 30 cigarettes per day.
| Can 1 | Can 2 | Can 3 | Can 4 | |
| Nicotine | 1.45 | 0.97 | 0.48 | 0.00 |
| Alcohol | 79.71 | 80.10 | 80.49 | 80.88 |
| Saccharine | 0.12 | 0.12 | 0.12 | 0.12 |
| Glycerine | 14.78 | 14.85 | 14.93 | 15.00 |
| Peppermint Flavour | 3.94 | 3.96 | 3.98 | 4.00 |
| All figures are percentages by volume. | ||||
[0013] The person wishing to give up smoking, upon feeling the need for a cigarette, takes the can which contains most nicotine and, in the way that breath fresheners are used, sprays into his or her mouth. One depression of the plunger is sufficient to dispense a suitable amount of liquid in atomized form. The first can is used each time that the person feels like smoking a cigarette until it is exhausted. The second aerosol can is then used in the same way and it will be understood that the person is, immediately the second can is brought into use, receiving a smaller dose of nicotine per depression of the pump than was being received during use of the first can. Thus while nicotine is still being provided, the amount provided has been decreased. Once the second can has been depleted the third can is brought into use and subsequently the fourth can which has therein no nicotine whatsoever. Thus the nicotine level of the patient is decreased gradually and the effects of a sudden reduction in the nicotine level in the body are avoided.
1. A plurality of containers each of which, apart from one, contains nicotine in liquid
form dispersed in at least one pharmaceutically acceptable carrier, the percentage
of nicotine by volume in each container being different to the percentage of nicotine
in each other container, and said one container having therein said pharmaceutically
acceptable carrier but no nicotine.
2. A plurality of containers according to claim 1, the number of containers being three,
two containers having nicotine therein with the percentage of nicotine in one of these
containers being greater than the percentage of nicotine in the other of these containers,
the third container containing said pharmaceutically acceptable carrier but no nicotine.
3. A plurality of containers according to claim 1, the number of containers being four,
three containers having nicotine therein with the percentage of nicotine in each of
these containers being different to the percentage in each of the others of these
three containers, the fourth container having therein at least one pharmaceutically
acceptable carrier but no nicotine.
4. A plurality of containers according to claim 3, wherein the percentage of nicotine
in said three containers is respectively about 1,5%, about 1% and about 0,5%.
5. A plurality of containers according to Claim 3, wherein the percentage of nicotine
in said three containers is respectively 1,45%, 0,97% and 0,48%.
6. A plurality of containers according to any one of Claims 1 to 5 and which are pump
operated aerosol containers.
1. Eine Mehrzahl von Behältern, von denen jeder, außer einem, Nikotin in flüssiger Form,
dispergiert in wenigstens einem pharmazeutisch geeigneten Träger, enthält, wobei der
Volumenprozentsatz an Nikotin in jedem Behälter unterschiedlich zum Prozentsatz an
Nikotin in jedem anderen Behälter ist und der eine genannte Behälter einen pharmazeutisch
geeigneten Träger, aber kein Nikotin, beinhaltet.
2. Eine Mehrzahl von Behältern nach Anspruch 1, wobei die Anzahl der Behälter drei ist,
zwei Behälter ihrerseits Nikotin beinhalten, der Prozentsatz an Nikotin in einem dieser
Behälter größer als der Prozentsatz an Nikotin in dem anderen Behälter ist, und der
dritte Behälter den genannten pharmazeutisch geeigneten Träger, aber kein Nikotin,
enthält.
3. Eine Mehrzahl von Behältern nach Anspruch 1, wobei die Anzahl der Behälter vier ist,
drei Behälter Nikotin beinhalten, der Prozentsatz an Nikotin in jedem dieser Behälter
unterschiedlich zu dem Prozentsatz in jedem der anderen drei Behälter ist, und wobei
der vierte Behälter wenigstens einen pharmazeutisch geeigneten Träger, aber kein Nikotin,
beinhaltet.
4. Eine Mehrzahl von Behältern nach Anspruch 3, wobei der Prozentsatz an Nikotin in besagten
drei Behältern ungefähr 1,5 %, ungefähr 1 % bzw. ungefähr 0,5 % ist.
5. Eine Mehrzahl von Behältern nach Anspruch 3, wobei der Prozentsatz an Nikotin in besagten
drei Behältern 1,45 %, 0,97 % bzw. 0,48 % ist.
6. Eine Mehrzahl von Behältern nach einem der Ansprüche 1 bis 5, wobei die Behälter pumpbetriebene
Aerosolbehälter sind.
1. Pluralité de récipients dont chacun, excepté un, contient de la nicotine sous forme
liquide dispersée dans au moins un support pharmaceutiquement acceptable, le pourcentage
de nicotine en volume dans chaque récipient étant différent du pourcentage de nicotine
dans chaque autre récipient, et ledit premier récipient contenant ledit support pharmaceutiquement
acceptable mais pas de nicotine.
2. Pluralité de récipients selon la revendication 1, le nombre de récipients étant de
trois, deux récipients contenant de la nicotine, le pourcentage de nicotine dans un
de ces récipients étant supérieur au pourcentage de nicotine dans l'autre de ces récipients,
le troisième récipient contenant ledit support pharmaceutiquement acceptable mais
pas de nicotine.
3. Pluralité de récipients selon la revendication 1, le nombre de récipients étant de
quatre, trois récipients contenant de la nicotine, le pourcentage de nicotine dans
chacun de ces récipients étant différent du pourcentage dans chacun des autres de
ces trois récipients, le quatrième récipient contenant au moins un support pharmaceutiquement
acceptable mais pas de nicotine.
4. Pluralité de récipients selon la revendication 3, dans laquelle le pourcentage de
nicotine dans lesdits trois récipients est respectivement d'environ 1,5 %, d'environ
1 % et d'environ 0,5 %.
5. Pluralité de récipients selon la revendication 3, dans laquelle le pourcentage de
nicotine dans lesdits trois récipients est respectivement de 1,45 %, 0,97 % et 0,48
%.
6. Pluralité de récipients selon l'une quelconque des revendications 1 à 5 et qui sont
des récipients aérosols actionnés par une pompe.