(19)
(11) EP 1 013 766 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
29.01.2003 Bulletin 2003/05

(43) Date of publication A2:
28.06.2000 Bulletin 2000/26

(21) Application number: 99309491.1

(22) Date of filing: 29.11.1999
(51) International Patent Classification (IPC)7C12N 15/49, C07K 14/16, C07K 16/10, C12N 5/10, G01N 33/569, G01N 33/68
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 30.11.1998 US 110292
08.02.1999 US 119138
04.11.1999 US 433428

(71) Applicant: Ortho-Clinical Diagnostics, Inc.
Rochester, NY 14626-5101 (US)

(72) Inventors:
  • De Leys, Robert
    Three Bridges, NJ 08887-2128 (US)
  • Zheng, Jian
    Raritan, NJ 08869 (US)

(74) Representative: Mercer, Christopher Paul 
Carpmaels & Ransford 43, Bloomsbury Square
London WC1A 2RA
London WC1A 2RA (GB)

   


(54) Peptides for the detection of HIV-1-Group O


(57) This invention relates to peptides and their preparation. The peptides each have a sequence that corresponds to the immunodominant region of the HIV-1 group O gp41 envelope protein. The sequence is characterized in that it does not correspond to any known naturally occurring group O sequence or variant. Furthermore, the peptide binds anti-HIV-1 group O antibodies. There are several uses for the peptides, including the detection of antibodies produced in response to HIV-1 group O infection. The peptides may also be incorporated in mosaics and expressed recombinantly.





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