(19) |
 |
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(11) |
EP 1 013 766 A3 |
(12) |
EUROPEAN PATENT APPLICATION |
(88) |
Date of publication A3: |
|
29.01.2003 Bulletin 2003/05 |
(43) |
Date of publication A2: |
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28.06.2000 Bulletin 2000/26 |
(22) |
Date of filing: 29.11.1999 |
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(84) |
Designated Contracting States: |
|
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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Designated Extension States: |
|
AL LT LV MK RO SI |
(30) |
Priority: |
30.11.1998 US 110292 08.02.1999 US 119138 04.11.1999 US 433428
|
(71) |
Applicant: Ortho-Clinical Diagnostics, Inc. |
|
Rochester, NY 14626-5101 (US) |
|
(72) |
Inventors: |
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- De Leys, Robert
Three Bridges, NJ 08887-2128 (US)
- Zheng, Jian
Raritan, NJ 08869 (US)
|
(74) |
Representative: Mercer, Christopher Paul |
|
Carpmaels & Ransford 43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB) |
|
|
|
(54) |
Peptides for the detection of HIV-1-Group O |
(57) This invention relates to peptides and their preparation. The peptides each have
a sequence that corresponds to the immunodominant region of the HIV-1 group O gp41
envelope protein. The sequence is characterized in that it does not correspond to
any known naturally occurring group O sequence or variant. Furthermore, the peptide
binds anti-HIV-1 group O antibodies. There are several uses for the peptides, including
the detection of antibodies produced in response to HIV-1 group O infection. The peptides
may also be incorporated in mosaics and expressed recombinantly.