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(11) | EP 1 075 483 B1 |
(12) | EUROPEAN PATENT SPECIFICATION |
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(54) |
HYGROMYCIN A DERIVATIVES HYGROMYCIN A DERIVATE DERIVES D'HYGROMYCINE A |
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Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention). |
Background Of The Invention
Summary of the Invention
R1 is H and R2 is -NR3R4, -NR4C(O)R3, -OC(O)NR3R4 or -OR3;
or R1 and R2 are taken together to form =N-OR3, =CR4R3, =CR4C(O)R3, =CR4C(O)OR3, or =CR4C(O)NR3R4;
each R3 is independently selected from H, C1-C10 alkyl, C2-C10 alkenyl, -(CH2)t(C3-C10 cycloalkyl), -(CH2)t(C6-C10 aryl), and -(CH2)t(4-10 membered heterocyclic), wherein t is an integer ranging from 0 to 5, said alkyl group optionally contains 1 or 2 hetero moieties selected from O, -S(O)j- wherein j is an integer ranging from 0 to 2, and -N(R7)- with the proviso that two O atoms, two S atoms, or an O and S atom are not attached directly to each other; said cycloalkyl, aryl and heterocyclic R3 groups are optionally fused to a benzene ring, a C5-C8 saturated cyclic group, or a 4-10 membered heterocyclic group; the (CH2)t- moieties of the foregoing R3 groups optionally include a carbon-carbon double or triple bond where t is an integer between 2 and 5; and the foregoing R3 groups, except H but including any optional fused rings referred to above, are optionally substituted by 1 to 5 R5 groups, with the proviso that R3 is not H, methyl or ethyl where R1 is H and R2 is -OR3;
each R4 is independently H or C1-C10 alkyl;
each R5 is independently selected from C1-C10 alkyl, C3-C10 cycloalkyl, halo, cyano, nitro, trifluoromethyl, difluoromethoxy, trifluoromethoxy, azido, -OR6, -C(O)R6, -C(O)OR6, -NR7C(O)OR9, -OC(O)R6, -NR7SO2R9, -SO2NR6R7, -NR7C(O)R6, -C(O)NR6R7, -NR6R7, -S(O)j(CH2)m(C6-C10 aryl), -S(O)j(C1-C6 alkyl), wherein j is an integer ranging from 0 to 2, -(CH2)m(C6-C10 aryl), -O(CH2)m(C6-C10 aryl), -NR7(CH2)m(C6-C10 aryl), and -(CH2)m(4-10 membered heterocyclic), wherein m is an integer ranging from 0 to 4; said alkyl group optionally contains 1 or 2 hetero moieties selected from O, -S(O)j- wherein j is an integer ranging from 0 to 2, and -N(R7)- with the proviso that two O atoms, two S atoms, or an O and S atom are not attached directly to each other; said cycloalkyl, aryl and heterocyclic R5 groups are optionally fused to a C6-C10 aryl group, a C5-C8 saturated cyclic group, or a 4-10 membered heterocyclic group; and said alkyl, cycloalkyl, aryl and heterocyclic R5 groups are optionally substituted by 1 to 5 substituents independently selected from halo, cyano, nitro, trifluoromethyl, difluoromethoxy, trifluoromethoxy, azido, -NR7SO2R9, -SO2NR6R7, -C(O)R6, -C(O)OR6, -OC(O)R6, -NR7C(O)OR9, -NR7C(O)R6, -C(O)NR6R7, -NR6R7, -OR6, C1-C10 alkyl, -(CH2)m(C6-C10 aryl), and -(CH2)m(4-10 membered heterocyclic), wherein m is an integer ranging from 0 to 4;
each R6 is independently selected from H, C1-C10 alkyl, C3-C10 cycloalkyl, -(CH2)m(C6-C10 aryl), and -(CH2)m(4-10 membered heterocyclic), wherein m is an integer ranging from 0 to 4; said alkyl group optionally includes 1 or 2 hetero moieties selected from O, -S(O)j- wherein j is an integer ranging from 0 to 2, and -N(R7)- with the proviso that two O atoms, two S atoms, or an O and S atom are not attached directly to each other; said cycloalkyl, aryl and heterocyclic R6 groups are optionally fused to a C6-C10 aryl group, a C5-C8 saturated cyclic group, or a 4-10 membered heterocyclic group; and the foregoing R6 substituents, except H, are optionally substituted by 1 to 5 substituents independently selected from halo, cyano, nitro, trifluoromethyl, difluoromethoxy, trifluoromethoxy, azido, -C(O)R7, -C(O)OR7, -OC(O)R7, -NR7C(O)R8, -C(O)NR7R8, -NR7R8, hydroxy, C1-C6 alkyl, and C1-C6 alkoxy;
each R7 and R8 is independently H or C1-C6 alkyl; and,
R9 is selected from the substituents provided in the definition of R6 except H.
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(benzofuran-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(benzofuran-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-phenylmethyloxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-phenylmethyloxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3,4-dichlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3,4-dichlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-pyridinyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-(4-morpholinyl)phenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[cyclohexylmethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-b-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,4-dichlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(furan-3-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(furan-3-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(1,3-benzodioxol-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(1,3-benzodioxol-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-cyclohexylphenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-aminophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[[(4-aminomethyl)phenyl]methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[3-(4-chlorophenyl)propyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[3-(4-chlorophenyl)propyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-(trifluoromethoxy)phenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-(1-piperidinyl)phenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[2-(phenylthio)ethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(benzofuran-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(benzofuran-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2-phenylpyrimidin-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-fluoro-4-methoxyphenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3,4-dihydro-2H-1-benzopyran-4-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(5,6-dideoxy-5-(methyl(phenylmethyl)amino-α-L-galacto-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol;
5-Deoxy-5-[[3-[4-[(5,6-dideoxy-5-phenylamino-α-L-galacto-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-O-neo-inositol;
5-Deoxy-5-[[3-[4-[(6-deoxy-5-O-[(3,4-dichlorophenyl)methyl]-β-D-altro-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(furan-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(5-methyl-β-D-arabino-hept-5-(E)-enofuranuron-1-ylic acid)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, ethyl ester;
5-Deoxy-5-[[3-[4-[[N-(furan-2-yl)methyl]-(5-methyl-β-D-arabino-hept-5-(E)-enofuranuron-1-yl-amide)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[3-(phenyl)propyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(2-propen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(2-propen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-methylphenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxypheny)]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-methoxyphenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-(trifluoromethyl)phenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-5-O-[(4-chlorophenyl)methyl]-β-altro-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[diphenylmethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-5-phenylcarbamate-β-D-altro-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol;
5-Deoxy-5-[[3-[4-[(6-deoxy-5-[(3,4-dichlorophenyl)methyl]carbamate-β-D-altro-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chloro-2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl)amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chloro-4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxypheny)]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-5-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol. (E)-O-[(3-chloro-5-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(5-chloro-2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(5-chloro-2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3,5-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3,5-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-chloro-3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-chloro-3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-chloro-1,3-benzodioxol-6-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-chloro-1,3-benzodioxol-6-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofurenos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(5-chloro-1,3-benzodioxol-6-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(5-chloro-1,3-benzodioxol-6-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-chloro-1,3-benzodioxol-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-chloro-1,3-benzodioxol-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,3-dihydrobenzofuran-6-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,3-dihydrobenzofuran-6-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O [(2,3-dihydrobenzofuran-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino-1,2-O-methylene-D-neo-inositol, (Z)-O [(2,3-dihydrobenzofuran-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(1,2,3,4-tetrahydronaphthalen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(1,2,3,4-tetrahydronaphthalen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(7-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(7-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(8-chloro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(8-chloro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(6-chloro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenylamino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(6-chloro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(8-fluoro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(8-fluoro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(6-fluoro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(6-fluoro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(quinolin-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(quinolin-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(quinolin-3-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(quinolin-3-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl)-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[4-(phenylmethyl)phenylmethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[4-(phenylmethyl)phenylmethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[4-(phenoxy)phenylmethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[4-(phenoxy)phenylmethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3,5-dichlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3,5-dichlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino-1,2-O-methylene-D-neo-inositol, (Z)-O-(phenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(phenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(3-chloro-4-fluorophenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(3-chloro-4-fluorophenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl)-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-(4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,1,3-benzoxadiazol-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxypheny)]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,1,3-benzoxadiazol-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,3,5,6-tetrafluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,3,5,6-tetrafluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,3-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,3-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-phenyl-furan-3-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-phenyl-furan-3-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-phenyl-furan-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-phenyl-furan-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,3-difluoro-6-methoxyphenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,3-difluoro-6-methoxyphenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chloro-thiophen-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-thiophen-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(5-chloro-thiophen-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propeny)]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(5-chloro-thiophen-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chloro-2,6-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-2,6-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[1-(3-chlorophenyl)ethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(3-difluoromethoxy-phenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxypheny)]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(3-difluoromethoxy-phenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(4-difluoromethoxy-phenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(4-difluoromethoxy-phenyl)oxime;
and the pharmaceutically acceptable salts and solvates of said compounds.5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(1,3-benzodioxol-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-(4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(benzofuran-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3,5-dichlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3,5-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3,5-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chloro-2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chloro-4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-chloro-3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-chloro-3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-phenyl-furan-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-5-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,3-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,3,5,6-tetrafluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(3-chloro-4-fluorophenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(3-chloro-4-fluorophenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(5-chloro-thiophen-2-yl)methyl]oxime;
and the pharmaceutically acceptable salts and solvates of said compounds.Detailed Description of the Invention
Assay
Preparation 1
Preparation 2
Experimental Procedures For Examples
5"-Oxime Ether Preparations
Preparation of hydroxylamine reagents for synthesis of oxime ethers, Examples 1-92, 1A-116A
1) Preparation of phthalimide-protected benzylic or aliphatic hydroxylamines:
A Mitsunobu reaction with diethyl azodicarboxylate and triphenylphosphine was used to couple N-hydroxyphthalimide and the alcohol starting material, according to the procedure of E. Grochowski and J. Jurczak, Synthesis (1976) 682.
Reaction of N-hydroxyphthalimide (1 equivalent) with the halide starting material (1.2-2 equivalents) was carried out in DMSO solution, using potassium carbonate (0.6 - 2 equivalents) as base. The reactions were carried out at room temperature, generally by stirring overnight. Pouring the reaction mixture into cold water provided a precipitate, which was filtered to give the phthalimide-protected hydroxylamine. In many cases, this material was directly deprotected; silica gel chromatography can also be employed, using ethyl acetate-hexane mixtures, to purify the phthalimide-protected hydroxylamine.
2) Removal of the phthalimide protecting group to provide the benzylic or aliphatic hydroxylamine:
3) Preparation of O-arylhydroxylamines:
Preparation of miscellaneous alcohol and halide starting materials used in synthesis of hydroxylamines:
Preparation of oxime ethers, Methods (A - I), Examples 1-92, 1A-116A
Method A
Method B
Method C
Method D
Method E
Method F
Method G
Method H
Method I
Purification of oxime ethers, Methods (J - N-1)
Method J
Method K
Method L
Method M
Method N
Method N-1
5"-Amine Preparations, Examples 93-101
Methods (O - R) for preparation of amine derivatives
Method O
Method P
Method Q
Method R
5"-Amide Preparations, Examples 102-104
Preparation of amide derivatives, Methods S - T
Synthesis of persilylated 5"-amino hygromycin A
a) A solution of hygromycin A, tert-butyldimethylsilyl chloride (12 equivalents), and imidazole (12 equivalents) in DMF (hygromycin concentration 0.25 M) were stirred at 80°C for 20 hours. After removal of the DMF under reduced pressure, the resulting residue was extracted with diethyl ether. The combined ether extracts were washed with water, then saturated sodium chloride solution, dried over sodium sulfate, filtered, and concentrated. The crude product was purified by silica gel chromatography, eluting with 10% ethyl acetate/hexanes.
b) A solution of persilylated hygromycin A in 1:1 methanol: tetrahydrofuran (0.2 M) was treated with sodium borohydride (0.5 equivalents) and stirred at room temperature for 18 hours. After removal of solvents under reduced pressure, the residue was dissolved in chloroform, washed with saturated sodium bicarbonate solution, dried over sodium sulfate, filtered, and concentrated to give crude persilylated 5"-alcohol. Purification was carried out by column chromatography eluting with 10%-20% ethyl acetate/ hexanes. Subsequent analysis of Mosher esters showed the stereochemistry at 5" of the major product of this reaction to be R.
c) A solution of the 5"-alcohol in methylene chloride (0.2 M) at 0°C was treated with triethylamine (3 equivalents), followed by methanesulfonyl chloride (2 equivalents) and stirred at room temperature for 24 hours. The reaction mixture was then poured into water and extracted with methylene chloride. The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo to give the 5"-mesylate.
d) The 5"-mesylate in DMF (0.2 M) was treated with sodium azide (10 equivalents) and stirred at 95°C for 18 hours. The reaction mixture was poured into water, extracted with diethyl ether, washed with brine, dried with sodium sulfate, filtered, and concentrated in vacuo. The crude 5"-azide was purified by silica gel chromatography, eluting with 10% -ethyl acetate/ hexanes.
e) A solution of the 5"-azide and triphenylphosphine (3 equivalents) in toluene (5"-azide concentration 0.2 M) was stirred at 105°C 18 hours. The toluene was removed under reduced pressure and replaced with tetrahydrofuran/ water (10/1) (hygromycin derivative concentration 0.1 M) and stirred at 75°C 5 hours. The reaction mixture was poured into water and extracted with diethyl ether. The combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo. The crude product was purified by silica gel chromatography, eluting with 20% ethyl acetate/ hexanes, to provide persilylated 5"-amino hygromycin A.
Method S
a) Persilylated 5"-amino hygromycin A and the appropriate carboxylic acid (2 equivalents) were stirred together with EEDQ (1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, 2 equivalents) in THF at 70°C for three hours (persilylated hygromycin concentration 0.1 M). The reaction mixture was poured into water and extracted with ether. The combined organic layers were washed with 5% sodium carbonate solution, water, and saturated sodium chloride solution. After being dried over sodium sulfate, the organic extracts were filtered and concentrated to provide a residue which was chromatographed on silica gel using a mixture of ethyl acetate and hexanes, to provide the desired amide as its persilyl protected derivative.
b) The silyl groups were removed by treatment of a solution of 5"-modified hexasilylhygromycin A (1 equivalent, 0.1 M) with a 1 M solution of tetrabutylamonium fluoride (TBAF, 10 equivalents) in THF at room temperature for 14-24 hours. The THF was removed in vacuo and the crude material was dissolved in a mixture of water and methanol. This solution/suspension was applied to a column of Dowex (50X4-400) resin (10 -30 g of resin/mmol of TBAF, which had been converted to the OH form by treatment with 0.1-0.2N sodium hydroxide and then washed with one column volume (CV) of water). The column was gravity eluted with 1-3 CV of water until the TBAF was removed and then eluted with 50% aqueous methanol with the aid of nitrogen pressure to provide the desired amide product. If additional purification was required, silica gel chromatography was performed (method J-N).
Method T
5"-Ether, Carbamate Preparations, Examples 105 - 131
Methods (U - Z)
Method U for the preparation of 5"-hygromycin A benzyl ethers.
Method V
Method W
Method X
Method Y
Method Z
5"-Olefin Preparations, Examples 132 - 140
Preparation of olefin derivatives, Methods AA-EE
Method AA
Method BB
Method CC
Method DD
Method EE
R1 is H and R2 is -NR3R4, -NR4C(O)R3, -OC(O)NR3R4 or -OR3;
or R1 and R2 are taken together to form =N-OR3, =CR4R3, =CR4C(O)R3, =CR4C(O)OR3, or =CR4C(O)NR3R4;
each R3 is independently selected from H, C1-C10 alkyl, C2-C10 alkenyl, -(CH2)t(C3-C10 cycloalkyl), -(CH2)t(C6-C10 aryl), and -(CH2)t(4-10 membered heterocyclic), wherein t is an integer ranging from 0 to 5, said alkyl group optionally contains 1 or 2 hetero moieties selected from O, -S(O)j- wherein j is an integer ranging from 0 to 2, and -N(R7)- with the proviso that two O atoms, two S atoms, or an O and S atom are not attached directly to.each other; said cycloalkyl, aryl and heterocyclic R3 groups are optionally fused to a benzene ring, a C5-C8 saturated cyclic group, or a 4-10 membered heterocyclic group; the -(CH2)t- moieties of the foregoing R3 groups optionally include a carbon-carbon double or triple bond where t is an integer between 2 and 5; and the foregoing R3 groups, except H but including any optional fused rings referred to above, are optionally substituted by 1 to 5 R5 groups, with the proviso that R3 is not H, methyl or ethyl where R1 is H and R2 is -OR3;
each R4 is independently H or C1-C10 alkyl;
each R5 is independently selected from C1-C10 alkyl, C3-C10 cycloalkyl, halo, cyano, nitro, trifluoromethyl, difluoromethoxy, trifluoromethoxy, azido, -OR6, -C(O)R6, -C(O)OR6, -NR7C(O)OR9, -OC(O)R6, -NR7SO2R9, -SO2NR6R7, -NR7O-(O)R6, -C(O)NR6R7, -NR6R7, -S(O)j(CH2)m(C6-C10 aryl), -S(O)j(C1-C6 alkyl), wherein j is an integer ranging from 0 to 2, -(CH2)m(C6-C10 aryl), -O(CH2)m(C6-C10 aryl), -NR7(CH2)m(C6-C10 aryl), and -(CH2)m(4-10 membered heterocyclic), wherein m is an integer ranging from 0 to 4; said alkyl group optionally contains 1 or 2 hetero moieties selected from O, -S(O)j- wherein j is an integer ranging from 0 to 2, and -N(R7)- with the proviso that two O atoms, two S atoms, or an O and S atom are not attached directly to each other; said cycloalkyl, aryl and heterocyclic R5 groups are optionally fused to a C6-C10 aryl group, a C5-C8 saturated cyclic group, or a 4-10 membered heterocyclic group; and said alkyl, cycloalkyl, aryl and heterocyclic R5 groups are optionally substituted by 1 to 5 substituents independently selected from halo, cyano, nitro, trifluoromethyl, difluoromethoxy, trifluoromethoxy, azido, -NR7SO2R9, -SO2NR6R7, -C(O)R6, -C(O)OR6, -OC(O)R6, -NR7C(O)OR9, -NR7C(O)R6, -C(O)NR6R7, -NR6R7, -OR6, C1-C10 alkyl, -(CH2)m(C6-C10 aryl), and -(CH2)m(4-10 membered heterocyclic), wherein m is an integer ranging from 0 to 4;
each R6 is independently selected from H, C1-C10 alkyl, C3-C10 cycloalkyl, -(CH2)m(C6-C10 aryl), and -(CH2)m(4-10 membered heterocyclic), wherein m is an integer ranging from 0 to 4; said alkyl group optionally includes 1 or 2 hetero moieties selected from O, -S(O)j- wherein j is an integer ranging from 0 to 2, and -N(R7)- with the proviso that two O atoms, two S atoms, or an O and S atom are not attached directly to each other; said cycloalkyl, aryl and heterocyclic R6 groups are optionally fused to a C6-C10 aryl group, a C5-C8 saturated cyclic group, or a 4-10 membered heterocyclic group; and the foregoing R6 substituents, except H, are optionally substituted by 1 to 5 substituents independently selected from halo, cyano, nitro, trifluoromethyl, difluoromethoxy, trifluoromethoxy, azido, -C(O)R7, -C(O)OR7, -OC(O)R7, - NR7C(O)R8, -C(O)NR7R8, -NR7R8, hydroxy, C1-C6 alkyl, and C1-C6 alkoxy;
each R7 and R8 is independently H or C1-C6 alkyl; and,
R9 is selected from the substituents provided in the definition of R6 except H.
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(benzofuran-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(benzofuran-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-phenylmethyloxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-phenylmethyloxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3,4-dichlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3,4-dichlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-pyridinyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-(4-morpholinyl)phenyl]methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[cyclohexylmethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-b-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl)-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,4-dichlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(furan-3-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(furan-3-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)-oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(1,3-benzodioxol-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(1,3-benzodioxol-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxypheny)]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino)-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-cyclohexylphenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy][3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-aminophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl)-2-methyl-1-oxo-2-(E)-propenyl)amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[[(4-aminomethyl)phenyl]methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[3-(4-chlorophonyl)propyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[3-(4-chlorophenyl)propyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-(trifluoromethoxy)phenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenylamino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-(1-piperidinyl)phenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[2-(phenylthio)ethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(benzofuran-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(benzofuran-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino)-1,2-O-methylene-D-neo-inositol, (E)-O-[(2-phenylpyrimidin-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-fluoro-4-methoxyphenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3,4-dihydro-2H-1-benzopyran-4-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(5,6-dideoxy-5-(methyl(phenylmethyl)amino-α-L-galacto-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol;
5-Deoxy-5-[[3-[4-[(5,6-dideoxy-5-phenylamino-α-L-galacto-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol;
5-Deoxy-5-[[3-[4-[(6-deoxy-5-O-[(3,4-dichlorophenyl)methyl]-β-D-altro-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(furan-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(5-methy)-β-D-arabino-hept-5-(E)-enofuranuron-1-ylic acid)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, ethyl ester;
5-Deoxy-5-[[3-[4-[[N-(furan-2-yl)methyl]-(5-methyl-β-D-arabino-hept-5-(E)-enofuranuron-1-yl-amide)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[3-(phenyl)propyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(2-propen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy)-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(2-propen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-methylphenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-methoxyphenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-(trifluoromethyl)phenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-5-O-[(4-chlorophenyl)methyl]-β-D-altro-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[diphenylmethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-5-phenylcarbamate-β-D-altro-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol;
5-Deoxy-5-[[3-[4-[(6-deoxy-5-[(3,4-dichlorophenyl)methyl]carbamate-β-D-altro-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2,-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chloro-2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chloro-4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-5-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chloro-5-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(5-chloro-2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(5-chloro-2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3,5-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3,5-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-chloro-3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-chloro-3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-chloro-1,3-benzodioxol-6-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-chloro-1,3-benzodioxol-6-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(5-chloro-1,3-benzodioxol-6-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(5-chloro-1,3-benzodioxol-6-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-chloro-1,3-benzodioxol-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, -(Z)-O-[(4-chloro-1,3-benzodioxol-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,3-dihydrobenzofuran-6-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,3-dihydrobenzofuran-6-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,3-dihydrobenzofuran-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,3-dihydrobenzofuran-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(1,2,3,4-tetrahydronaphthalen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(1,2,3,4-tetrahydronaphthalen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(7-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(7-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(8-chloro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(8-chloro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(6-chloro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(6-chloro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(8-fluoro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(8-fluoro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(6-fluoro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl)amin-1,2-O-methylene-D-neo-inositol, (Z)-O-(6-fluoro-3,4-dihydro-2H-1-benzopyran-4-yl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(quinolin-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(quinolin-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(quinolin-3-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(quinolin-3-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[4-(phenylmethyl)phenylmethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[4-(phenylmethyl)phenylmethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[4-(phenoxy)phenylmethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[4-(phenoxy)phenylmethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3,5-dichlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3,5-dichlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(phenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(phenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(3-chloro-4-fluorophenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(3-chloro-4-fluorophenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,1,3-benzoxadiazol-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,1,3-benzoxadiazol-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,3,5,6-tetrafluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,3,5,6-tetrafluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,3-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,3-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-phenyl-furan-3-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-phenyl-furan-3-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-phenyl-furan-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-pheny)-furan-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,3-difluoro-6-methoxyphenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,3-difluoro-6-methoxyphenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chloro-thiophen-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-thiophen-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2,-O-methylene-D-neo-inositol, (E)-O-[(5-chloro-thiophen-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(5-chloro-thiophen-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methytene-D-neo-inositol, (E)-O-[(3-chloro-2,6-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-2,6-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methy-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[1-(3-chlorophenyl)ethyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(3-difluoromethoxy-phenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxypheny)]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(3-difluoromethoxy-phenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(4-difluoromethoxy-phenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, -(E)-O-(4-difluoromethoxy-phenyl)oxime;
and the pharmaceutically acceptable salts and solvates of said compounds.5-Deoxy-5-[[3-(4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(1,3-benzodioxol-5-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(benzofuran-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3,5-dichlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3,5-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3,5-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chloro-2-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3-chloro-4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-chloro-3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-(4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-chloro-3-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(4-chlorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(4-phenyl-furan-2-yl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3-chloro-5-fluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(3,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(3,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,3-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-[(2,4-difluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(2,3,5,6-tetrafluorophenyl)methyl]oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-(3-chloro-4-fluorophenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (E)-O-(3-chloro-4-fluorophenyl)oxime;
5-Deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylene-D-neo-inositol, (Z)-O-[(5-chloro-thiophen-2-yl)methyl]oxime;
and the pharmaceutically acceptable salts and solvates of said compounds.R1 H bedeutet und R2 -NR3R4, -NR4C(O)R3, -OC(O)NR3R4 oder -OR3 bedeutet;
oder R1 und R2 zusammen =N-OR3, =CR4R3, =CR4C(O)R3, =CR4C(O)OR3 oder =CR4C(O)NR3R4 bilden;
wobei jeder Rest R3 unabhängig voneinander ausgewählt ist aus H, C1-C10-Alkyl, C2-C10-Alkenyl, -(CH2)t(C3-C10-Cycloalkyl), - (CH2)t(C6-C10-Aryl) und -(CH2)t(4-10-gliedriger Heterocyclusrest) ausgewählt ist, wobei t eine ganze Zahl im Bereich von 0 bis 5 ist, die Alkylgruppe optional 1 oder 2 Heteroeinheiten enthält, die aus 0, -S(O)j-, wobei j eine ganze Zahl im Bereich von 0 - 2 ist, und -N(R7)- ausgewählt sind mit dem Vorbehalt, dass zwei O-Atome, zwei S-Atome oder ein 0- und ein S-Atom nicht direkt aneinander gebunden sind; die Cycloalkyl-, Aryl- und heterocyclischen Gruppen von R3 optional an einen Benzolring, eine gesättigte cyclische C5-C8-Gruppe oder eine 4-10-gliedrige heterocyclische Gruppe kondensiert sind; die -(CH2)t-Einheiten der im vorhergehenden genannten R3-Gruppen optional eine Kohlenstoff-Kohlenstoff-Doppel- oder Dreifachbindung umfassen, wobei t eine ganze Zahl zwischen 2 und 5 ist; und die im vorhergehenden genannten R3-Gruppen mit Ausnahme von H, jedoch einschließlich beliebiger im vorhergehenden angegebener optionaler kondensierter Ringe optional mit 1 bis 5 R5-Gruppen substituiert sind, mit dem Vorbehalt, dass R3 nicht H, Methyl oder Ethyl bedeutet, wenn R1 H ist und R2 -OR3 ist;(Z)-O-[(3-Fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(3-Fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(Benzofuran-2-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(Benzofuran-2-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-Phenylmethyloxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-Darabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neoinosit;
(E)-O-Phenylmethyloxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-Darabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neoinosit;
(Z)-O-[(4-Chlorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(3,4-Dichlorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3,4-Dichlorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(4-Pyridinyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(4-(4-Morpholinyl)phenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[Cyclohexylmethyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(4-Fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(2,4-Dichlorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3,4-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(Furan-3-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(Furan-3-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(1,3-Benzodioxol-5-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(1,3-Benzodioxol-5-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3-Chlorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(4-Cyclohexylphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3-Aminophenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[[(4-Aminomethyl)phenyl]methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[3-(4-Chlorphenyl)propyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[3-(4-Chlorphenyl)propyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(3-(Trifluormethoxy)phenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(4-(1-Piperidinyl)phenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(2-(Fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[2-(Phenylthio)ethyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(Benzofuran-5-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(Benzofuran-5-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(2-Phenylpyrimidin-5-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3-Fluor-4-methoxyphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3,4-Dihydro-2H-1-benzopyran-4-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
5-Desoxy-5-[[3-[4-[(5,6-didesoxy-5-(methyl(phenylmethyl)-amino-α-L-galacto-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neoinosit;
5-Desoxy-5-[[3-[4-[(5,6-didesoxy-5-phenylamino-α-L-galactofuranos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
5-Desoxy-5-[[3-[4-[(6-desoxy-5-O-[(3,4-dichlorphenyl)methyl]-β-D-altro-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(Furan-2-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
Ethylester von 5-Desoxy-5-[[3-[4-[(5-methyl-β-D-arabino-hept-5-(E)-enofuranuron-1-ylsäure)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
5-Desoxy-5-[[3-[4-[[N-(furan-2-yl)methyl]-(5-methyl-β-Darabino-hept-5-(E)-enofuranuron-1-yl-amid)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[3-(Phenyl)propyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-(2-Propen-1-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-O-neoinosit;
(E)-O-(2-Propen-1-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neoinosit;
(E)-O-[(4-Methylphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(4-Methoxyphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3-(Trifluormethyl)phenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
5-Desoxy-5-[[3-[4-[(6-desoxy-5-O-[(4-chlorphenyl)methyl]-β-Daltro-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[Diphenylmethyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neoinosit;
5-Desoxy-5-[[3-[4-[(6-desoxy-5-phenylcarbamat-β-D-altrofuranos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
5-Desoxy-5-[[3-[4-[(6-desoxy-5-[(3,4-dichlorphenyl)methyl]-carbamat-β-D-altro-furanos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neoinosit;
(Z)-O-[(3-Chlorphenyl)methyl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(3-Chlor-2-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3-Chlor-2-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(3-Chlor-4-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3-Chlor-4-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(3-Chlor-5-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3-Chlor-5-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(5-Chlor-2-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(5-Chlor-2-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(3,5-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3,5-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(4-Chlor-3-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(4-Chlor-3-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(4-Chlor-1,3-benzodioxol-6-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(4-Chlor-1,3-benzodioxol-6-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(5-Chlor-1,3-benzodioxol-6-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(5-Chlor-1,3-benzodioxol-6-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(4-Chlor-1,3-benzodioxol-5-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(4-Chlor-1,3-benzodioxol-5-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(2,3-dihydrobenzofuran-6-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(2,3-dihydrobenzofuran-6-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(2,3-dihydrobenzofuran-5-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(2,3-dihydrobenzofuran-5-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-(1,2,3,4-Tetrahydronaphthalin-1-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-(1,2,3,4-Tetrahydronaphthalin-1-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-(7-Chlor-1,2,3,4-tetrahydronaphthalin-1-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-(7-Chlor-1,2,3,4-tetrahydronaphthalin-1-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-(7-Fluor-1,2,3,4-tetrahydronaphthalin-1-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-(7-Fluor-1,2,3,4-tetrahydronaphthalin-1-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-(8-Chlor-3,4-dihydro-2H-1-benzopyran-4-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-(8-Chlor-3,4-dihydro-2H-1-benzopyran-4-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-(6-Chlor-3,4-dihydro-2H-1-benzopyran-4-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-(6-Chlor-3,4-dihydro-2H-1-benzopyran-4-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-(8-Fluor-3,4-dihydro-2H-1-benzopyran-4-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-(8-Fluor-3,4-dihydro-2H-1-benzopyran-4-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-(6-Fluor-3,4-dihydro-2H-1-benzopyran-4-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-(6-Fluor-3,4-dihydro-2H-1-benzopyran-4-yl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]-amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(Chinolin-7-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(Chinolin-2-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(Chinolin-3-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(Chinolin-3-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[4-(Phenylmethyl)phenylmethyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit; (Z)-O-[4-(Phenylmethyl)phenylmethyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-2,2-Omethylen-D-neo-inosit; (E)-O-[4-(Phenoxy)phenylmethyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[4-(Phenoxy)phenylmethyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(3,5-Dichlorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3,5-Dichlorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-(Phenyl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-Darabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neoinosit;
(E)-O-(Phenyl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-Darabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neoinosit;
(Z)-O-(3-Chlor-4-fluorphenyl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-(3-Chlor-4-fluorphenyl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(4-Fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(4-Chlorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(3,4-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(2,4-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(2,4-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(2,1,3-Benzoxadiazol-5-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(2,1,3-Benzoxadiazol-5-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(2,3,5,6-Tetrafluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(2,3,5,6-Tetrafluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxyl-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(2,3-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(2,3-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(4-Phenyl-furan-3-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(4-Phenyl-furan-3-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(4-Phenyl-furan-2-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(4-Phenyl-furan-2-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(2,3-Difluor-6-methoxyphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(2,3-Difluor-6-methoxyphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3-Chlor-thiophen-2-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(3-Chlor-thiophen-2-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(5-Chlor-thiophen-2-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(5-Chlor-thiophen-2-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3-Chlor-2,6-difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(3-Chlor-2,6-difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(2-Fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[1-(3-Chlorphenyl)ethyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-(3-Difluormethoxy-phenyl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-(3-Difluormethoxy-phenyl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-(4-Difluormethoxy-phenyl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-(4-Difluormethoxy-phenyl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit
und den pharmazeutisch akzeptablen Salzen und Solvaten der Verbindungen.(Z)-O-[(1,3-Benzodioxol-5-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3-Chlorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(3-Chlorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(3-Fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(3-Fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(Benzofuran-2-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(3,5-Dichlorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(3,5-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3,5-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(3-Chlor-2-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3-Chlor-2-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(3-Chlor-4-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-((6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3-Chlor-4-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(4-Chlor-3-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(4-Chlor-3-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(4-Fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(4-Fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(4-Chlorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-[(4-Chlorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-2-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(4-Phenyl-furan-2-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(3-Chlor-5-fluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(3,4-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(3,4-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(2,3-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-((2,4-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(E)-O-[(2,4-Difluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-[(2,3,5,6-Tetrafluorphenyl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit;
(Z)-O-(3-Chlor-4-fluorphenyl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(E)-O-(3-Chlor-4-fluorphenyl)oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-O-methylen-D-neo-inosit;
(Z)-O-[(5-Chlor-thiophen-2-yl)methyl]oxim von 5-Desoxy-5-[[3-[4-[(6-desoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-(E)-propenyl]amino]-1,2-Omethylen-D-neo-inosit
und die pharmazeutisch akzeptablen Salze und Solvate der Verbindungen.5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl)-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(benzofuranne-2-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(benzofuranne-2-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-phénylméthyloxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-phénylméthyloxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(4-chlorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3,4-dichlorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3,4-dichlorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(4-pyridinyl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(4-(4-morpholinyl)phényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[cyclohexylméthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(4-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-(4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(2,4-dichlorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3,4-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(furanne-3-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(furanne-3-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(1,3-benzodioxol-5-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(1,3-benzodioxol-5-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3-chlorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(4-cyclohexylphényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3-aminophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[[(4-aminométhyl)phényl]méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[3-(4-chlorophényl)propyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[3-(4-chlorophényl)propyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3-trifluorométhoxy)phényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(4-(1-pipéridinyl)phényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(2-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[2-phénylthio)éthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(benzofuranne-5-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(benzofuranne-5-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(2-phénylpyrimidine-5-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3-fluoro-4-méthoxyphényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3,4-dihydro-2H-1-benzopyranne-4-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(5,6-didésoxy-5-(méthyl(phé-nylméthyl)amino-α-L-galactofurannose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol ;
5-désoxy-5-[[3-[4-[(5,6-didésoxy-5-phénylamino-α-L-galactofurannose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol ;
5-désoxy-5-[[3-[4-[(6-désoxy-5-O-[(3,4-dichlorophényl)méthyl]-β-D-altrofurannose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(furanne-2-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(acide 5-méthyl-β-D-arabino-hept-5-(E)-énofurannurone-1-ylique)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néoinositol, ester éthylique ;
5-désoxy-5-[[3-[4-[[N-(furanne-2-yl)méthyl]-(5-méthyl-β-D-arabinohept-5-(E)-énofurannurone-1-yl-amide)-oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[3-(phényl)propyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-(2-propène-1-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-(2-propène-1-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(4-méthylphényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(4-méthoxyphényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3-(trifluorométhyl)phényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-5-O-[(4-chlorophényl)méthyl]-β-D-altro-furannose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabinohexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[diphénylméthyl]oxime ;
5-désoxy-5-[[3-(4-[(6-désoxy-5-phénylcarbamate-β-D-altro-furannose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl)amino]-1,2-O-méthylène-D-néo-inositol ;
5-désoxy-5-[[3-[4-[(6-désoxy-5-[(3,4-dichlorophényl)méthyl]carbamate-β-D-altro-furannose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3-chlorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3-chloro-2-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3-chloro-2-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3-chloro-4-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3-chloro-4-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3-chloro-5-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3-chloro-5-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(5-chloro-2-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(5-chloro-2-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3,5-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3,5-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(4-chloro-3-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(4-chloro-3-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(4-chloro-1,3-benzodioxole-6-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(4-chloro-1,3-benzodioxole-6-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(5-chloro-1,3-benzodioxole-6-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxa-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(5-chloro-1,3-benzodioxole-6-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(4-chloro-1,3-benzodioxole-5-yl)méthyl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(4-chloro-1,3-benzodioxole-5-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(2,3-dihydrobenzofuranne-6-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(2,3-dihydrobenzofuranne-6-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(2,3-dihydrobenzofuranne-5-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(2,3-dihydrobenzofuranne-5-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-(1,2,3,4-tétrahydronaphtalène-1-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-(1,2,3,4-tétrahydronaphtalène-1-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-(7-chloro-1,2,3,4-tétrahydronaphtalène-1-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-(7-chloro-1,2,3,4-tétrahydronaphtalène-1-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-(7-fluoro-1,2,3,4-tétrahydronaphtalène-1-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-(7-fluoro-1,2,3,4-tétrahydronaphtalène-1-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-(8-chloro-3,4-dihydro-2H-1-benzopyranne-4-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-(8-chloro-3,4-dihydro-2H-1-benzopyranne-4-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-(6-chloro-3,4-dihydro-2H-1-benzopyranne-4-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-(6-chloro-3,4-dihydro-2H-1-benzopyranne-4-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-(8-fluoro-3,4-dihydro-2H-1-benzopyranne-4-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-(8-fluoro-3,4-dihydro-2H-1-benzopyranne-4-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-(6-fluoro-3,4-dihydro-2H-1-benzopyranne-4-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-(6-fluoro-3,4-dihydro-2H-1-benzopyranne-4-yl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(quinoléine-2-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(quinoléine-2-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(quinoléine-3-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(quinoléine-3-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[4-(phénylméthyl)phénylméthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[4-(phénylméthyl)phénylméthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[4-(phénoxy)phénylméthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[4-(phénoxy)phénylméthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-((3,5-dichlorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3,5-dichlorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy)-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-0-méthylène-D-néo-inositol, (Z)-O-(phényl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-(phényl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-(3-chloro-4-fluorophényl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-(3-chloro-4-fluorophényl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(4-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(4-chlorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3,4-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(2,4-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(2,4-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(2,1,3-benzoxadiazole-5-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(2,1,3-benzoxadiazole-5-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(2,3,5,6-tétrafluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(2,3,5,6-tétrafluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(2,3-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(2,3-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(4-phénylfuranne-3-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(4-phénylfuranne-3-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(4-phénylfuranne-2-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(4-phénylfuranne-2-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(2,3-fluoro-6-méthoxyphényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(2,3-fluoro-6-méthoxyphényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3-chlorothiophène-2-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3-chlorothiophène-2-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl)amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(5-chlorothiophène-2-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(5-chlorothiophène-2-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3-chloro-2,6-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3-chloro-2,6-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(2-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[1-(3-chlorophényl)éthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-(3-difluorométhoxyphényl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-(3-difluorométhoxyphényl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-(4-difluorométhoxyphényl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-(4-difluorométhoxyphényl)oxime ;
et les sels pharmaceutiquement acceptables et les produits de solvatation de ces composés.5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(1,3-benzodioxole-5-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3-chlorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3-chlorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(benzofuranne-2-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3,5-dichlorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3,5-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-O-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3,5-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3-chloro-2-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3-chloro-2-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3-chloro-4-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3-chloro-4-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(4-chloro-3-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-0-méthylène-D-néo-inositol, (E)-O-[(4-chloro-3-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(4-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(4-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(4-chlorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(4-chlorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(4-phénylfuranne-2-yl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3-chloro-5-fluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(3,4-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(3,4-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(2,3-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(2,4-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-[(2,4-difluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(2,3,5,6-tétrafluorophényl)méthyl]oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2 -O-méthylène-D-néo-inositol, (Z)-O-(3-chloro-4-fluorophényl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (E)-O-(3-chloro-4-fluorophényl)oxime ;
5-désoxy-5-[[3-[4-[(6-désoxy-β-D-arabino-hexofurannose-5-ulose-1-yl)oxy]-3-hydroxyphényl]-2-méthyl-1-oxo-2-(E)-propényl]amino]-1,2-O-méthylène-D-néo-inositol, (Z)-O-[(5-chlorothiophène-2-yl)méthyl]oxime ;
et les sels pharmaceutiquement acceptables et les produits de solvatation de ces composés.