TECHNICAL FIELD OF THE INVENTION
[0001] The present invention relates to a solid preparation comprising a compound represented
by the formula (I) to be shown below, a pH control agent and a calcium antagonist,
which is superior in the stability and dissolution property of the compound (I) represented
by the formula (I) and the calcium antagonist.
(Background of the Invention)
[0002] It is important that pharmaceutical products be effective and safe. Even if a pharmaceutical
product is effective and safe immediately after production, if the drug is easily
decomposed or denatured during distribution of the pharmaceutical product, it is not
considered to be effective and safe as a pharmaceutical product. Therefore, the stability
of the drug is extremely important for pharmaceutical products.
[0003] To secure effectiveness and safety of a pharmaceutical product, not only the effectiveness
and safety of the active ingredient itself are important but also the properties of
the pharmaceutical preparation, such as the drug dissolution property in the body
and the like, are extremely important.
For example, when dissolution of the drug from the pharmaceutical preparation is too
late, the blood concentration of the drug does not reach an effective level, and the
expected efficacy may not be sufficiently exhibited.
On the other hand, when dissolution of the drug from the pharmaceutical preparation
is too fast, the blood concentration of the drug increases sharply, causing a high
risk of side effects.
In other words, pharmaceutical products are required to ensure the stability of the
drug and a certain level of the drug dissolution, in addition to the effectiveness
and safety.
Meanwhile, the drug dissolution property is known to correlate with the solubility
thereof. In general, lower solubility of a drug is known to cause slower drug dissolution
property.
[0004] Incidentally, benzimidazole derivative (I) having a strong angiotensin II receptor
antagonistic activity
[0005]

[0006] wherein R
1 is a monocyclic nitrogen-comprising heterocyclic group having a hydrogen atom that
can be deprotonized, R
2 is an esterified carboxyl group, and R
3 is an optionally substituted lower alkyl, or a salt thereof (hereinafter to be sometimes
referred to as compound (I)), particularly, a salt of (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl
2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
(patent document 1) is a promising therapeutic drug for hypertension and the like.
However, the properties of a pharmaceutical preparation need to be adjusted to stabilize
compound (I) because compound (I) is unstable in the neutral pH range, at which pharmaceutical
preparations are generally produced. Nevertheless, the solubility of compound (I)
is low at the pH range where compound (I) is stable. In addition, a combination drug
product composed of compound (I) and active ingredients such as calcium antagonist
and the like cannot be easily formulated into a pharmaceutical preparation superior
in the stability and dissolution property due to the difference in chemical properties.
[0007] As combination drug product, a combination of a compound having an angiotensin II
antagonistic activity and a compound having a calcium antagonistic action (patent
document 2) and an oral solid preparation containing acetaminophen obtained by a separating
granulation method to suppress the unpleasant taste of acetaminophen and prevent discoloration
thereof (patent document 3) are known. However, a combination drug product of compound
(I) and a calcium antagonist, which simultaneously achieves stability and solubility,
i.e., dissolution property, of the drug has not been known.
CITATION LIST
PATENT LITERATURE
SUMMARY OF THE INVENTION
PROBLEMS TO BE SOLVED BY THE INVENTION
[0009] A preparation comprising compound (I) and a calcium antagonist is effective for the
prophylaxis or treatment of circulatory diseases such as hypertension, cardiac failure,
diabetic nephropathy, arteriosclerosis and the like, and has extremely high clinical
usefulness.
It is an object of the present invention to provide a solid preparation superior in
the stability of compound (I) and a calcium antagonist as well as dissolution property
thereof.
MEANS OF SOLVING THE PROBLEMS
[0010] The present inventors have conducted intensive studies in an attempt to simultaneously
achieve the stability of compound (I) in a preparation and the dissolution property
thereof from the preparation, and found that the object can be unexpectedly accomplished
by the co-presence of a pH control agent and compound (I), and further, by adjusting,
with a pH control agent, the pH range of a solid preparation thereof to a pH range
in which the solubility of compound (I) becomes low. They have also found that even
when compound (I) and a calcium antagonist are used in combination, both of them show
superior stability. Moreover, they have found that compound (I) and a calcium antagonist
can be further stabilized by separately granulating compound (I) added with a pH control
agent and the calcium antagonist, and a preparation more superior in the dissolution
property of compound (I) as compared to general granulation preparations can be obtained,
which resulted in the completion of the present invention.
[0011] Accordingly, the present invention provides the following.
(1) A solid preparation comprising a compound represented by the formula (I)
[0012]

[0013] wherein R
1 is a monocyclic nitrogen-comprising heterocyclic group having a hydrogen atom that
can be deprotonized, R
2 is an esterified carboxyl group, and R
3 is an optionally substituted lower alkyl, or a salt thereof, a pH control agent and
a calcium antagonist.
(2) The solid preparation of the aforementioned (1), wherein the compound represented
by the formula (I) or a salt thereof is (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
potassium salt.
(3) The solid preparation of the aforementioned (1) or (2), wherein the calcium antagonist
is amlodipine or an acid addition salt thereof.
(4) The solid preparation of the aforementioned (1) or (2), wherein the calcium antagonist
is amlodipine besylate.
(5) The solid preparation of the aforementioned (1), wherein the compound represented
by the formula (I) or a salt thereof is (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
potassium salt and the calcium antagonist is amlodipine besylate.
(6) The solid preparation of the aforementioned (1), wherein the pH control agent
has pH 2 to 5.
(7) The solid preparation of the aforementioned (1), wherein the pH control agent
is an acidic substance selected from tartaric acid, citric acid, lactic acid, fumaric
acid, succinic acid, phosphoric acid, malic acid, ascorbic acid, acetic acid and acidic
amino acid, or a salt thereof, or a solvate thereof.
(8) The solid preparation of the aforementioned (1), wherein the pH control agent
is monosodium fumarate or a combination of fumaric acid and a sodium ion donor.
(9) A solid preparation comprising a first part comprising a compound represented
by the formula (I):
[0014]

[0015] wherein R
1 is a monocyclic nitrogen-comprising heterocyclic group having a hydrogen atom that
can be deprotonized, R
2 is an esterified carboxyl group, and R
3 is an optionally substituted lower alkyl, or a salt thereof and a pH control agent,
and a second part comprising a calcium antagonist, wherein the first part and the
second part are individually granulated.
(10) The solid preparation of the aforementioned (1), which is a multi-layer tablet
having a first layer comprised of a first part comprising the compound represented
by the formula (I):
[0016]

[0017] wherein R
1 is a monocyclic nitrogen-comprising heterocyclic group having a hydrogen atom that
can be deprotonized, R
2 is an esterified carboxyl group, and R
3 is an optionally substituted lower alkyl, or a salt thereof and the pH control agent,
and a second layer comprised of a second part comprising the calcium antagonist.
(11) The solid preparation of the aforementioned (1), wherein the pH control agent
is contained in a proportion of 0.01 - 20 wt% of the preparation.
(12) A method of stabilizing a compound represented by the formula (I):
[0018]

[0019] wherein R
1 is a monocyclic nitrogen-comprising heterocyclic group having a hydrogen atom that
can be deprotonized, R
2 is an esterified carboxyl group, and R
3 is an optionally substituted lower alkyl, or a salt thereof and a calcium antagonist
in a solid preparation, which comprises adding a pH control agent to the solid preparation
comprising the compound represented by the formula (I) or a salt thereof, and a calcium
antagonist.
(13) A method of improving dissolution of a compound represented by the formula (I)
or a salt thereof from a solid preparation, which comprises adding a pH control agent
to the solid preparation comprising the compound represented by the formula (I):
[0020]

[0021] wherein R
1 is a monocyclic nitrogen-comprising heterocyclic group having a hydrogen atom that
can be deprotonized, R
2 is an esterified carboxyl group, and R
3 is an optionally substituted lower alkyl, or a salt thereof, and a calcium antagonist;
and the like.
BRIEF DESCRIPTION OF THE DRAWINGS
[0022]
Fig. 1 shows the drug dissolution ratios of the tablets obtained in Reference Example
1 and Comparative Example 1.
Fig. 2 shows the drug dissolution ratios of tablets obtained in Formulation Example
14 and Comparative Example 2.
(Detailed Description of the Invention)
[0023] The solid preparation of the present invention is explained in detail in the following.
The solid preparation of the present invention comprises compound (I), a pH control
agent and a calcium antagonist. The solid preparation of the present invention is
superior in the stability of compound (I), as well as superior in the dissolution
property of the compound. In addition, it is superior in the stability of the calcium
antagonist.
[0024] In the aforementioned formula (I), R
1 is a monocyclic nitrogen-comprising heterocyclic group having a hydrogen atom that
can be deprotonized, such as a tetrazolyl group or a group represented by the formula
[0025]

[0026] wherein i is -O- or -S-, j is >C=O, >C=S or >S(O)m wherein m is 0, 1 or 2 (e.g.,
4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl group, etc.) and the like are preferable.
A 4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl group includes three tautomers (a', b' and
c') represented by the formulas:
[0027]

[0028] and 4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl group includes all of the above-mentioned
a', b' and c'.
[0029] In the aforementioned formula (I), R
2 is an esterified carboxyl group and, for example, preferably a carboxyl group esterified
by lower (C
1-4) alkyl optionally substituted by a substituent selected from a hydroxyl group, an
amino group, a halogen atom, lower (C
2-6) alkanoyloxy (e.g., acetyloxy, pivaloyloxy, etc.), lower (C
4-6) cycloalkanoyloxy, (lower (C
1-6) alkoxy)carbonyloxy (e.g., methoxycarbonyloxy, ethoxycarbonyloxy, etc.), (lower (C
3-7) cycloalkoxy) carbonyloxy (e.g., cyclohexyloxycarbonyloxy, etc.), lower (C
1-4) alkoxy and 5-methyl-2-oxo-1,3-dioxolen-4-yl (e.g., (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxycarbonyl
group, 1-(cyclohexyloxycarbonyloxy)ethoxycarbonyl group) and the like.
[0030] In the aforementioned formula (I), R
3 is an optionally substituted lower alkyl, and preferably a lower (C
1-5) alkyl optionally substituted by a substituent selected from a hydroxyl group, an
amino group, a halogen atom and a lower (C
1-4)alkoxy group (preferably lower (C
2-3) alkyl; particularly preferably ethyl).
[0031] As a salt of the compound represented by the formula (I), a pharmaceutically acceptable
salt can be mentioned and, for example, a salt of a compound represented by the formula
(I) with an inorganic base, a salt thereof with an organic base, a salt thereof with
an inorganic acid, a salt thereof with an organic acid, a salt thereof with a basic
or acidic amino acid and the like can be mentioned. Preferable examples of the salt
with an inorganic base include alkali metal salt such as sodium salt, potassium salt
and the like; alkaline earth metal salt such as calcium salt, magnesium salt and the
like; aluminum salt, ammonium salt and the like. Preferable examples of the salt with
an organic base include salts with trimethylamine, triethylamine, pyridine, picoline,
ethanolamine, diethanolamine, triethanolamine, dicyclohexylamine, N,N'-dibenzylethylenediamine
and the like. Preferable examples of the salt with an inorganic acid include salts
with hydrochloric acid, hydrobromic acid, nitric acid, sulfuric acid, phosphoric acid
and the like. Preferable examples of the salt with an organic acid include salts with
formic acid, acetic acid, trifluoroacetic acid, fumaric acid, oxalic acid, tartaric
acid, maleic acid, citric acid, succinic acid, malic acid, methanesulfonic acid, benzenesulfonic
acid, p-toluenesulfonic acid and the like. Preferable examples of the salt with a
basic amino acid include salts with arginine, lysine, ornithine and the like. Preferable
examples of the salt with an acidic amino acid include salts with aspartic acid, glutamic
acid and the like.
[0032] As a compound represented by the formula (I) or a salt thereof, a salt of (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl
2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
is preferable, and (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
potassium salt is particularly preferable.
The salt of a compound represented by the formula (I) may be hydrate or non-hydrate.
In addition, compound (I) may be a solvate including hydrate or a non-solvate.
[0033] Compound (I) is preferably crystalline, and preferably has the melting point of 100
- 250°C, particularly 120 - 200°C, especially 130 - 180°C.
[0034] Compound (I) is contained in the solid preparation of the present invention in a
proportion of 0.1 - 60 wt%, preferably 1 - 40 wt%, more preferably 5 - 30 wt%.
[0035] As the pH control agent to be used in the present invention, any pH control agent
can be used as long as it can simultaneously achieve the stability of compound (I)
in a preparation and dissolution property thereof from the preparation, and is applicable
to pharmaceutical products. Plural pH control agents may be used in combination. As
the pH control agent to be used in the present invention, the pH control agent showing
pH of about 2 to about 5, preferably about 3 to about 5, more preferably about 3 to
about 4 is preferably used. For example, an acidic substance such as tartaric acid,
citric acid, lactic acid, fumaric acid, phosphoric acid, malic acid, succinic acid,
ascorbic acid, acetic acid, acidic amino acid (e.g., glutamic acid, aspartic acid)
and the like, inorganic salts of these acidic substances (e.g., alkali metal salt,
alkaline earth metal salt, ammonium salt, etc.), salts of these acidic substances
with an organic base (e.g., basic amino acid such as lysine, arginine, etc., meglumine,
etc.), and a solvate thereof (e.g., hydrate), and the like are used. In addition,
the pH control agent simultaneously achieves the stability of calcium antagonists
in the preparation and the dissolution property from the preparation.
Here, the pH of the pH control agent is measured under the following conditions. To
be precise, it is a pH of a solution or suspension obtained by dissolving or suspending
a pH control agent in water at a concentration of 1% w/v at 25°C.
[0036] As the pH control agent to be used in the present invention, an acidic substance
and a basic substance are combined, and the obtained pH control agent may be adjusted
such that the pH of the solution or suspension is about 2 to about 5, preferably about
3 to about 5, more preferably about 3 to about 4, when the combined pH control agent
is dissolved or suspended in water at 25°C at a concentration of 1% w/v. Examples
of the acidic substance to be used in combination include, in addition to the acidic
substances having a pH of about 2 to about 5 mentioned above and salts thereof, strong
acids such as hydrochloric acid, sulfuric acid, phosphoric acid and the like. Examples
of the basic substance to be used in combination include inorganic bases (e.g., sodium
hydroxide, potassium hydroxide, sodium carbonate, sodium hydrogen carbonate, magnesium
carbonate, calcium carbonate, magnesium oxide, ammonia, synthetic hydrotalcite), organic
bases (e.g., basic amino acid such as lysine, arginine, etc., meglumine, and the like)
and the like.
Furthermore, preferable examples of the pH control agent to be used in the present
invention include those whose solutions have a buffering ability at said pH, such
as sodium dihydrogen phosphate, monosodium fumarate, a combination of fumaric acid
and a sodium ion donor and the like.
As the pH control agent to be used in the present invention, monosodium fumarate or
a combination of fumaric acid and sodium ion donor is particularly preferable, and
fumaric acid and sodium hydroxide may be used in combination.
[0037] The solid preparation of the present invention contains the pH control agent in a
proportion of 0.01 - 20 wt%, preferably 0.05 - 10 wt%, more preferably 0.1 - 5 wt%.
[0038] Examples of the calcium antagonist in the present invention include manidipine, nifedipine,
amlodipine, efonidipine, nicardipine and the like. The calcium antagonist in the present
invention also includes salts of the compounds exemplified as the above-mentioned
calcium antagonists.
As the calcium antagonist in the present invention, amlodipine or a salt thereof is
preferable, amlodipine or an acid addition salt thereof is more preferable, and a
salt of amlodipine is further preferable. As the salt of amlodipine, amlodipine besylate,
amlodipine maleate and the like are preferable, and amlodipine besylate is more preferable.
[0039] The calcium antagonist in the present invention is generally contained in the solid
preparation in a proportion of 0.05 - 60 wt% (appropriately adjusted so that the total
of compound (I) and pH control agent will not exceed 100%), preferably 0.1 - 40 wt%,
more preferably 0.5 - 20 wt%. Specifically, amlodipine (based on free form) is generally
contained in a proportion of 0.05 - 60 wt%, preferably 0.1 - 40 wt%, more preferably
0.5 - 20 wt%.
[0040] A preferable form of the solid preparation of the present invention is, for example,
a preparation wherein compound (I) is (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
potassium salt and the calcium antagonist is amlodipine besylate.
[0041] Examples of the solid preparation of the present invention include solid dosage form
suitable for oral administration such as tablets, granules, fine granules, capsules,
pills and the like. Accordingly, the embodiments of the solid preparation of the present
invention include the following preparations and the like.
(1) A solid preparation obtained by granulating a mixture of compound (I), a pH control
agent and a calcium antagonist (single granulation preparation).
(2) A solid preparation comprising a first part comprising compound (I) and a pH control
agent and a second part comprising a calcium antagonist, which is obtained by separately
granulating the first part and the second part (separating granulation preparation
- single layer tablet).
(3a) A solid preparation obtained by compression molding the first part and the second
part, each independently granulated (separating granulation preparation - multi-layer
tablet).
(3b) A solid preparation obtained by coating one part with the other part in the individually
granulated first part and the second part, (separating granulation preparation - coated
tablet).
[0042] The solid preparation of the above-mentioned (1) (single granulation preparation)
simultaneously achieves dissolution property of each of compound (I) and a calcium
antagonist from the preparation and stability thereof due to the addition of a pH
control agent. In the solid preparations of the above-mentioned (2), (3a) and (3b)
(separating granulation preparations), the dissolution property and stability thereof
of each of compound (I) and a calcium antagonist are more improved.
[0043] The solid preparation of the above-mentioned (1) can be produced according to a method
known per se (e.g., the method described in the
General Rules for Preparations, The Japanese Pharmacopoeia 14th Edition).
For example, when tablets are to be prepared, compound (I), a pH control agent, a
calcium antagonist, additives and the like are mixed, a binder is added to give granules,
a lubricant and the like are added to the granule and the mixture is tableted to give
a tablet. Granules and fine granules can also be produced by the method almost similar
to that of the tablet.
Capsules can be produced by filling the above-mentioned granules or fine granules
in a capsule containing gelatin, hydroxypropylmethylcellulose and the like, or filling
the active ingredient together with a filler in a capsule containing gelatin, hydroxypropylmethylcellulose
and the like.
[0044] For production of a solid preparation, additives conventionally used in the field
of pharmaceutical preparations may be added. Examples of the additive include filler,
disintegrant, binder, lubricant, colorant, pH control agent, surfactant, stabilizer,
acidulant, flavor, glidant and the like. These additives are used in amounts conventionally
employed in the field of pharmaceutical preparations.
[0045] Examples of the filler include starches such as cornstarch, potato starch, wheat
starch, rice starch, partly pregelatinized starch, pregelatinized starch, porous starch
and the like; sugar or sugar alcohols such as lactose, fructose, glucose, mannitol
(e.g., D-mannitol), sorbitol (e.g., D-sorbitol), erythritol (e.g., D-erythritol),
sucrose and the like: and anhydrous calcium phosphate, crystalline cellulose, microcrystalline
cellulose, Glycyrrhiza uralensis, sodium hydrogen carbonate, calcium phosphate, calcium
sulfate,
calcium carbonate, precipitated calcium carbonate, calcium silicate and the like.
[0046] Examples of the disintegrant include amino acid, starch, cornstarch, carboxymethylcellulose,
calcium carboxymethylcellulose, sodium carboxymethyl starch, carmellose sodium, carmellose
calcium, croscarmellose sodium, crospovidone, low-substituted hydroxypropylcellulose,
hydroxypropylstarch, sodium carboxymethyl starch and the like.
[0047] Examples of the binder include crystalline cellulose (e.g., microcrystalline cellulose),
hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, gelatin,
starch, gum arabic powder, tragacanth, carboxymethylcellulose, sodium alginate, pullulan,
glycerol and the like.
[0048] Preferable examples of the lubricant include magnesium stearate, stearic acid, calcium
stearate, talc (purification talc), sucrose esters of fatty acids, sodium stearyl
fumarate and the like.
[0049] Examples of the colorant include food colors such as Food Color Yellow No. 5, Food
Color Red No. 2, Food Color Blue No. 2 and the like, food lake colors, red ferric
oxide and the like.
[0050] Examples of the surfactant include sodium lauryl sulfate, polysorbate 80, polyoxyethylene(160)polyoxypropylene(30)glycol
and the like.
Examples of the stabilizer include tocopherol, tetrasodium edetate, nicotinamide,
cyclodextrins and the like.
[0051] Examples of the acidulant include ascorbic acid, citric acid, tartaric acid, malic
acid and the like.
Examples of the flavor include menthol, peppermint oil, lemon oil, vanillin and the
like.
Examples of the glidant include light anhydrous silicic acid, hydrated silicon dioxide
and the like.
The above-mentioned additives may be used in a mixture of two or more kinds thereof
at an appropriately ratio.
[0052] The solid preparation of the above-mentioned (2) comprises the first part and the
second part, which are individually granulated, and can be produced by a method known
per se.
In the solid preparation of the above-mentioned (2), the first part of the present
invention is a part (composition) comprising compound (I) and a pH control agent.
[0053] In the present invention, the pH control agent is used in an amount of preferably
0.01 - 20 parts by weight, more preferably 0.05 - 10 parts by weight, further preferably
0.1 - 5 parts by weight, per 100 parts by weight of the above-mentioned first part.
[0054] The weight ratio of compound (I) to pH control agent (compound (I):pH control agent)
is preferably 0.1 - 50:1, more preferably 1 - 30:1, further preferably 5 - 25:1.
[0055] The above-mentioned first part is not limited as long as it has a shape and size
permitting formation of a solid preparation together with the below-mentioned second
part.
[0056] The above-mentioned first part may further contain additives conventionally used
in the field of pharmaceutical preparations. As the additives, those similar to the
aforementioned are used.
The above-mentioned first part can be produced by mixing and granulating compound
(I) and a pH control agent, together with the above-mentioned additives as necessary
according to a method known per se.
[0057] The above-mentioned first part preferably contains compound (I) (preferably, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl
2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
potassium salt, hereinafter compound A); a pH control agent (preferably fumaric acid
and sodium hydroxide); a filler (preferably mannitol and crystalline cellulose); and
a binder (preferably hydroxypropylcellulose).
[0058] In the present invention, the second part (composition) contains a calcium antagonist.
The above-mentioned second part is not limited as long as it has a shape and size
permitting formation of a solid preparation together with the aforementioned first
part.
[0059] The above-mentioned second part may further contain additives conventionally used
in the field of pharmaceutical preparations. As the additives, those similar to the
aforementioned are used.
Specifically, it contains a calcium antagonist (preferably amlodipine besylate); a
filler (preferably mannitol and crystalline cellulose); and a binder (preferably hydroxypropylcellulose).
[0060] The above-mentioned second part can be produced by mixing and granulating a calcium
antagonist together with the above-mentioned additives as necessary according to a
method known per se.
The calcium antagonist is used in an amount of preferably 0.1 - 60 parts by weight,
more preferably 0.5 - 40 parts by weight, further preferably 1 - 30 parts by weight,
per 100 parts by weight of the above-mentioned second part.
[0061] The weight ratio of the second part to the first part (second part: first part) in
the solid preparation of the present invention is preferably 0.03 - 10:1, more preferably
0.1 - 5:1, further preferably 0.3 - 3:1.
A single layer tablet produced by mixing individually granulated first and second
parts with additives conventionally used in the field of pharmaceutical preparations,
and then compressing the mixture is also encompassed in the solid preparation of the
present invention. A capsule produced by filling the above-mentioned single layer
tablet in a capsule (e.g., hydroxypropylmethylcellulose capsule) is also encompassed
in the solid preparation of the present invention.
In addition, a capsule produced by directly filling the first part and the second
part, which are separately granulated, or together with the above-mentioned additives
in a capsule (e.g., hydroxypropylmethylcellulose capsule) is also encompassed in the
solid preparation of the present invention.
[0062] The solid preparation of the above-mentioned (3a) can be produced by individually
granulating the first part and the second part and compression molding these parts.
The solid preparation of the above-mentioned (3b) can be produced by individually
granulating the first part and the second part and coating one of them with the other.
[0063] Specific examples of the above-mentioned solid preparation (3b) include [1] coated
tablet (A) comprising an inner core comprised of the first part and an outer layer
comprised of the second part; and [2] coated tablet (B) comprising an inner core comprised
of the second part and an outer layer comprised of the first part. Specific examples
of the above-mentioned solid preparation (3a) include [3] a multi-layer tablet having
a first layer comprised of the first part and a second layer comprised of the second
part.
[0064] The inner core comprised of the first part can be produced by, for example, granulating
compound (I) and a pH control agent together with additives as necessary. In addition,
an operation such as drying, sieving, compression and the like may be performed where
necessary after granulation.
[0065] The outer layer comprised of the second part can be produced by granulating a calcium
antagonist (e.g., amlodipine or a salt thereof) together with additives as necessary.
The coating is performed by, for example, compression, coating and the like. In addition,
the additive is preferably a binder and the like.
[0066] During production of coated tablet (A), an inactive intermediate layer may be formed
between an inner core and an outer layer so as to prevent a direct contact between
them. The intermediate layer contains, for example, the following coating base and
coating additives. The intermediate layer preferably contains a water-soluble film
coating base and a glidant.
[0067] The above-mentioned coated tablet (B) can be produced in the same manner as in tablet
(A) except that the second part is used as an inner core and the first part is used
as an outer layer.
[0068] The multi-layer tablet in the present invention is a solid preparation comprised
of a first part comprising a compound represented by the formula (I) or a salt thereof
and a pH control agent, and a second part comprising a calcium antagonist, which has
a first layer comprised of the first part and a second layer comprised of the second
part.
[0069] The multi-layer tablet in the present invention is not particularly limited as long
as the first layer comprised of the first part and the second layer comprised of the
second part are integrally formed.
[0070] Moreover, the multi-layer tablet in the present invention may have an inactive intermediate
layer between the first layer and the second layer.
[0071] When the multi-layer tablet of the present invention has such an intermediate layer,
the adverse influences (decreased preservation stability such as time-course decomposition
of active ingredients, lowered effectiveness and the like, decreased dissolution stability
such as time-course changes in dissolution pattern of active ingredients and the like,
and so on) produced by interaction between the active ingredients can be more effectively
suppressed.
[0072] The multi-layer tablet can be produced, for example, according to the following
production steps.
Compound (I) and a pH control agent are mixed with additives as necessary, the obtained
mixture is granulated to give the first part. Operations such as drying, sieving and
the like may be performed where necessary after the granulation. Then, the first part
is mixed with additives as necessary to give the first layer.
Thereafter, a calcium antagonist is granulated with additives as necessary to give
the second part. The second part is mixed with additives as necessary to give the
second layer. The second layer is put on the above-mentioned first layer and compressed
(preferably tableted).
In this case, an inactive intermediate layer may be formed between respective layers
to avoid direct contact between them. The intermediate layer contains, for example,
the above-mentioned filler, disintegrant, binder, lubricant, colorant and the like.
[0073] A capsule produced by filling the above-mentioned coated tablet (A) or (B) or multi-layer
tablet in a capsule (e.g., hydroxypropylmethylcellulose capsule) is also encompassed
in the solid preparation of the present invention.
[0074] Moreover, a film coated preparation produced by film coating the solid preparation
of the above-mentioned (1), (2), (3a) and (3b) with a following coating base and additives
for coating is also encompassed in the solid preparation of the present invention.
[0075] Preferable examples of the coating base include a sugar coating base, a water-soluble
film coating base, an enteric film coating base, a sustained-release film coating
base and the like.
[0076] As the sugar coating base, sucrose is used. Furthermore, one or more kinds selected
from talc, precipitated calcium carbonate, gelatin, gum arabic, pullulan, Carnauba
wax and the like may be used in combination.
[0077] Examples of the water-soluble film coating base include cellulose polymers such as
hydroxypropylcellulose [e.g., grades: L, SL, SL-T, SSL (trade name); Nippon Soda Co.,
Ltd.], hydroxypropylmethylcellulose [e.g., TC-5 (grades: MW, E, EW, R, RW) (trade
name); Shin-Etsu Chemical Co., Ltd.], hydroxyethylcellulose, methylhydroxyethylcellulose
and the like; synthetic polymers such as polyvinylacetal diethylaminoacetate, aminoalkylmethacrylate
copolymer E [Eudragit E (trade name)], polyvinylpyrrolidone and the like; polysaccharides
such as pullulan and the like; and so on.
[0078] Examples of the enteric film coating base include cellulose polymers such as hydroxypropylmethylcellulose
phthalate, hydroxypropylmethylcellulose acetate succinate, carboxymethylethylcellulose,
cellulose acetate phthalate and the like; acrylic acid polymers such as methacrylic
acid copolymer L [Eudragit L (trade name)], methacrylic acid copolymer LD [Eudragit
L-30D55 (trade name)], methacrylic acid copolymer S [Eudragit S (trade name)] and
the like; naturally occurring substances such as shellac and the like; and so on.
[0079] Examples of the sustained-release film coating base include cellulose polymers such
as ethylcellulose and the like; acrylic acid polymers such as aminoalkylmethacrylate
copolymer RS [Eudragit RS (trade name)], ethyl acrylate-methyl methacrylate copolymer
suspension [Eudragit NE (trade name)] and the like; and so on.
[0080] Preferable examples of the coating additives include light protecting agents such
as titanium oxide and the like, glidants such as talc and the like, and/or colorants
such as red ferric oxide, yellow ferric oxide and the like; plasticizers such as polyethylene
glycol [e.g., macrogol 6000 (trade name)], triethyl citrate, castor oil, polysorbates
and the like; organic acids such as citric acid, tartaric acid, malic acid, ascorbic
acid and the like; and so on.
[0081] Moreover, the solid preparation of the present invention may have a distinguishable
embossing or printed letters, or a scored line for division.
[0082] The solid preparation of the present invention is preferably film-coated from the
aspects of easy administration, mechanical strength and the like.
The operations such as mixing, compression, coating and the like in the above-mentioned
production step are performed according to the methods conventionally used in the
pharmaceutical field.
[0083] For mixing, for example, blending machines such as a V-type mixer, a tumbler mixer
and the like; and granulator such as a high speed mixer granulator, a fluid bed granulator,
an extrusion granulator, a roller compactor and the like are used.
[0084] The compression is performed using, for example, a single stroke tableting machine,
a rotary tableting machine and the like.
When compression is performed using a single stroke tableting machine, a rotary tableting
machine and the like, it is generally preferable to employ a tableting pressure of
1 - 20 KN/cm
2 (preferably 5 - 15 KN/cm
2), and further, a taper cutting die to prevent capping.
[0085] The coating is performed using, for example, a film coating apparatus and the like.
[0086] The solid preparation of the present invention can be safely used as a medicine for
mammals (e.g., human, dog, rabbit, rat, mouse, etc.).
The solid preparation of the present invention can be safely administered orally or
parenterally (e.g., rectally).
While the dose of compound (I) to patients is determined in consideration of age,
body weight, general health condition, sex, diet, administration time, clearance rate,
combination of drugs and the like, as well as the severity of the disease for which
the patient is undergoing treatments, the daily dose is about 0.05 - 500 mg, preferably
0.1 - 100 mg, for an adult (body weight 60 kg).
While the dose of a calcium antagonist to patients is determined in consideration
of age, body weight, general health condition, sex, diet, administration time, clearance
rate, combination of drugs and the like, as well as the severity of the disease for
which the patient is undergoing treatments, the daily dose of amlodipine (based on
free form) is about 1 - 50 mg, preferably 2.5 - 10 mg, for an adult (body weight 60
kg).
[0087] Since compound (I) normalizes intracellular insulin information transduction mechanism,
which is the main cause of insulin resistance, reduces the insulin resistance and
enhances insulin action, and provides a glucose tolerance-improving effect, it can
be used as an agent for improving or preventing and/or treating a disease involving
insulin resistance in mammals (e.g., human, monkey, cat, swine, horse, bovine, mouse,
rat, guinea pig, dog, rabbit and the like). Examples of such diseases include insulin
resistance, impaired glucose tolerance; diabetes such as non-insulin dependent diabetes,
type II diabetes, type II diabetes associated with insulin resistance, type II diabetes
associated with impaired glucose tolerance and the like; various complications such
as hyperinsulinemia, hypertension associated with insulin resistance, hypertension
associated with impaired glucose tolerance, hypertension associated with diabetes
(e.g., type II diabetes and the like), hypertension associated with hyperinsulinemia,
insulin resistance associated with hypertension, impaired glucose tolerance associated
with hypertension, diabetes associated with hypertension, and hyperinsulinemia associated
with hypertension, diabetic complications [e.g., microangiopathy, diabetic neuropathy,
diabetic nephropathy, diabetic retinopathy, diabetic cataract, macroangiopathy, osteopenia,
diabetic hyperosmolar coma, infectious diseases (e.g., respiratory infection, urinary
tract infection, gastrointestinal infection, dermal soft tissue infection, inferior
limb infection etc.), diabetic gangrene, xerostomia, lowered sense of hearing, diabetic
cerebrovascular disease, diabetic peripheral circulatory disturbance, diabetic hypertension
and the like], diabetic cachexia and the like can be mentioned. Moreover, compound
(I) can also be used for the treatment of patients with diabetes, who shows a normal
high blood pressure.
[0088] Since compound (I) has a strong angiotensin II antagonistic action, moreover, it
is useful as a drug for the prophylaxis or treatment of a disease developed by (or
a disease whose onset is promoted by) constriction and growth of blood vessel or organ
disorder, which is expressed via angiotensin II receptor, the presence of angiotensin
II, or a factor induced by the presence of angiotensin II, in mammals (e.g., human,
monkey, cat, swine, horse, bovine, mouse, rat, guinea pig, dog, rabbit and the like).
[0089] Examples of such diseases include hypertension, circadian blood pressure abnormality,
heart diseases (e.g., cardiac hypertrophy, acute cardiac failure, chronic cardiac
failure including congestive cardiac failure, cardiaomyopathy, angina, myocarditis,
atrial fibrillation, arrhythmia, tachycardia, myocardial infarction etc.), cerebrovascular
disorders (e.g., asymptomatic cerebrovascular disorder, transient cerebral ischemic
attack, cerebral apoplexy, cerebrovascular dementia, hypertensive encephalopathy,
cerebral infarction, subarachnoid hemorrhage etc.), cerebral edema, cerebral circulatory
disorder, recurrence and sequela of cerebrovascular disorders (e.g., neurotic symptom,
psychic symptom, subjective symptom, disorder in daily living activities etc.), ischemic
peripheral circulation disorder, myocardial ischemia, venous insufficiency, progression
of cardiac insufficiency after myocardial infarction, renal diseases (e.g., nephritis,
glomerulonephritis, glomerulosclerosis, chronic renal failure, acute renal failure,
thrombotic vasculopathy, complication of dialysis, organ disorder including nephropathy
by radiation irradiation etc.), arteriosclerosis including atherosclerosis (e.g.,
aneurysm, coronary atherosclerosis, cerebral arterial sclerosis, peripheral arterial
sclerosis etc.), vascular hypertrophy, vascular hypertrophy or occlusion and organ
disorders after intervention (e.g., percutaneous coronary angioplasty, stenting, coronary
angioscopy, intravascular ultrasound, intracoronary thrombolysis etc.), vascular reocclusion
and restenosis after bypass surgery, polycythemia, hypertension, organ disorder and
vascular hypertrophy after transplantation, rejection after transplantation, ocular
diseases (e.g., glaucoma, ocular hypertension etc.), thrombosis, multiple organ disorder,
endothelial function disorder, hypertensive tinnitus, other cardiovascular diseases
(e.g., deep vein thrombosis, obstructive peripheral circulatory diturbance, arteriosclerosis
obliterans, thromboangiitis obliterans, ischemic cerebral circulatory disorder, Raynaud's
disease, Berger disease etc.), metabolic and/or nutritional disorders (e.g., obesity,
hyperlipidemia, hypercholesterolemia, hyperuricacidemia, hyperkalemia, hypernatremia
etc.), neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, AIDS encephalopathy etc.), central nervous system disorders
(e.g., damages such as cerebral hemorrhage and cerebral infarction, and sequela and
complication thereof, head injury, spinal injury, cerebral edema, sensory malfunction,
sensory functional disorder, autonomic nervous system disorder, autonomic nervous
system malfunction, multiple sclerosis etc.), dementia, defects of memory, disorder
of consciousness, amnesia, anxiety symptom, catatonic symptom, discomfort mental state,
psychopathies (e.g., depression, epilepsy, alcoholism etc.), inflammatory diseases
(e.g., arthritis such as chronic rheumatoid arthritis, osteoarthritis, rheumatoid
myelitis, periostitis etc.; inflammation after operation or injury; remission of swelling;
pharyngitis; cystitis; pneumonia; atopic dermatitis; inflammatory intestinal diseases
such as Crohn's disease, ulcerative colitis etc.; meningitis; inflammatory ocular
disease; pulmonary sarcoidosiss such as pneumonia, pulmonary silicosis, pulmonary
sarcoidosis, pulmonary tuberculosis etc.), allergic diseases (e.g., allergic rhinitis,
conjunctivitis, gastrointestinal allergy, pollinosis, anaphylaxis etc.), chronic obstructive
pulmonary disease, interstitial pneumonia, pneumocytis carinni pneumonia, collagen
diseases (e.g., systemic lupus erythematosus, scleroderma, polyarteritis etc.), hepatic
diseases (e.g., non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver diseases(NAFLD),
hepatitis including chronic hepatitis, hepatic cirrhosis etc.), portal hypertension,
digestive system disorders (e.g., gastritis, gastric ulcer, gastric cancer, gastric
disorder after operation, dyspepsia, esophageal ulcer, pancreatitis, colon polyp,
cholelithiasis, hemorrhoidal disease, varices ruptures of esophagus and stomach etc.),
blood and/or myelopoietic diseases (e.g., erythrocytosis, vascular purpura, autoimmune
hemolytic anemia, disseminated intravascular coagulation syndrome, multiple myelopathy
etc.), bone diseases (e.g., fracture, refracture, osteoporosis, osteomalacia, Paget's
disease of bone, sclerosing myelitis, chronic rheumatoid arthritis, joint tissue dysfunction
and the like caused by knee osteoarthritis and diseases similar to these), solid tumor,
tumors (e.g., malignant melanoma, malignant lymphoma, cancer of digestive organs (e.g.,
stomach, intestine etc.) etc.), cancer and cachexia following cancer, metastasis cancer,
endocrinopathy (e.g., Addison's disease, Cushing's syndrome, pheochromocytoma, primary
aldosteronism etc.), Creutzfeldt-Jakob disease, urinary organ and/or male genital
diseases (e.g., cystitis, prostatic hypertrophy, prostatic cancer, sex infectious
disease etc.), female disorders (e.g., climacteric disorder, gestosis, endometriosis,
hysteromyoma, ovarian disease, breast disease, sex infectious disease etc.), disease
relating to environment and occupational factors (e.g., radiation hazard, hazard by
ultraviolet, infrared or laser beam, altitude sickness etc.), respiratory diseases
(e.g., cold syndrome, pneumonia, asthma, pulmonary hypertension, pulmonary thrombosis
and pulmonary embolism etc.), infectious diseases (e.g., viral infectious diseases
with cytomegalovirus, influenza virus, herpes virus etc., rickettsiosis, bacterial
infectious disease etc.), toxemias (e.g., sepsis, septic shock, endotoxin shock, Gram-negative
sepsis, toxic shock syndrome etc.), otorhinolaryngological diseases (e.g., Meniere's
syndrome, tinnitus, dysgeusia, vertigo, disequilibrium, dysphagia etc.), skin diseases
(e.g., keloid, Hemangioma, psoriasis etc.), intradialytic hypotension, myasthenia
gravis, systemic diseases such as chronic fatigue syndrome and the like, and the like.
Since compound (I) can maintain a certain hypotensive action through day and night,
the dose and frequency can be reduced, and moreover, elevation of blood pressure before
and after awakening, which is particularly problematic in patients with hypertension,
can be suppressed more effectively.
[0090] In addition, continuous long-term suppression of the action of angiotensin II by
compound (I) results in the improvement or suppression of promotion of disorder or
abnormality in the biofunction and physiological action, that causes adult disorders
and various diseases linked with aging and the like, which in turn leads to the primary
and secondary prophylaxis of diseases or clinical conditions caused thereby or suppression
of the progression thereof. As the disorder or abnormality in the biofunction and
physiological action, for example, disorder or abnormality in automatic controlling
capability of cerebral circulation and/or renal circulation, disorder of circulation
(e.g., peripheral, cerebral, microcirculation etc.), disorder of blood-brain-barrier,
salt sensitivity, abnormal state of coagulation and fibrinolysis system, abnormal
state of blood and blood cell components (e.g., accentuation of platelet aggregation
action, malfunction of erythrocyte deformability, accentuation of leukocyte adhesiveness,
rise of blood viscosity etc.), production and function accentuation of growth factor
and cytokines (e.g., PDGF, VEGF, FGF, interleukin, TNF-α, MCP-1 etc.), accentuation
of production and infiltration of inflammatory cells, accentuation of production of
free radical, liposteatosis accentuation, endothelial function disorder, endothelium,
cell and organ dysfunction, edema, cell morphogenesis change of smooth muscle etc.
(morphogenesis to proliferation type etc.), production and function accentuation of
vasoactive substance and thrombosis inducers (e.g., endothelin, thromboxane A
2 etc.), abnormal constriction of blood vessel etc., metabolic disorder (e.g., serum
lipid abnormalities, dysglycemia etc.), abnormal growth of cell etc., angiogenesis
(including abnormal vasculogenesis during abnormal capillary reticular formation in
adventitia of arteriosclerotic lesion) and the like can be mentioned. Among them,
compound (I) can be used as an agent for the primary and secondary prophylaxis or
treatment of organ disorders associated with various diseases (e.g., cerebrovascular
disorder and organ disorder associated therewith, organ disorder associated with cardiovascular
disease, organ disorder associated with diabetes, organ disorder after intervention
etc.). In particular, since compound (I) has an activity of inhibiting proteinuria,
the compound can be used as an agent for protecting kidney. Therefore, compound (I)
can be advantageously used when the patients with insulin resistance, impaired glucose
tolerance, diabetes or hyperinsulinemia have concurrently developed the above-mentioned
diseases or clinical condition.
[0091] Since compound (I) has an activity of inhibiting body weight gain, it can be used
as a body weight gain inhibitor to mammals. Target mammals may be any mammals of which
body weight gain is to be avoided. The mammals may have a risk of body weight gain
genetically or may be suffering from lifestyle-related diseases such as diabetes,
hypertension and/or hyperlipidemia and the like. The body weight gain may be caused
by excessive feeding or diet without nutrient balance, or may be derived from combination
drug(e.g., agents for enhancing insulin sensitivity having PPARγ-agonistic activity
such as troglitazone, rosiglitazone, englitazone, ciglitazone, pioglitazone and the
like). In addition, body weight gain may be preliminary to obesity, or may be body
weight gain of obesity patients. Here, obesity is defined that BMI (body mass index;
body weight (kg)/[height (m)]
2) is not less than 25 for Japanese (criterion by Japan Society for the Study of Obesity),
or not less than 30 for westerner (criterion by WHO).
In addition, compound (I) can be used as an agent for the prophylaxis or treatment
of hypertension associated with obesity or an agent for the prophylaxis or treatment
of obesity associated with hypertension.
[0092] As for the diagnostic criteria of diabetes, the Japan Diabetes Society reported new
diagnostic criteria in 1999.
According to the report, diabetes is a condition showing any of a fasting blood glucose
level (glucose concentration of intravenous plasma) of not less than 126 mg/dl, a
75 g oral glucose tolerance test (75 g OGTT) 2 h level (glucose concentration of intravenous
plasma) of not less than 200 mg/dl, and a non-fasting blood glucose level (glucose
concentration of intravenous plasma) of not less than 200 mg/dl. A condition not falling
under the above-mentioned diabetes and different from "a condition showing a fasting
blood glucose level (glucose concentration of intravenous plasma) of less than 110
mg/dl or a 75 g oral glucose tolerance test (75 g OGTT) 2 h level (glucose concentration
of intravenous plasma) of less than 140 mg/dl" (normal type) is called a "borderline
type".
[0093] In addition, ADA (American Diabetes Association) reported new diagnostic criteria
of diabetes in 1997 and WHO in 1998.
According to these reports, diabetes is a condition showing a fasting blood glucose
level (glucose concentration of intravenous plasma) of not less than 126 mg/dl, or
a 75 g oral glucose tolerance test 2 h level (glucose concentration of intravenous
plasma) of not less than 200 mg/dl.
According to the above-mentioned reports, impaired glucose tolerance is a condition
showing a fasting blood glucose level (glucose concentration of intravenous plasma)
of less than 126 mg/dl and a 75 g oral glucose tolerance test 2 h level (glucose concentration
of intravenous plasma) of not less than 140 mg/dl and less than 200 mg/dl. According
to the report of ADA, a condition showing a fasting blood glucose level (glucose concentration
of intravenous plasma) of not less than 110 mg/dl and less than 126 mg/dl is called
IFG (Impaired Fasting Glucose). According to the report of WHO, among the IFG (Impaired
Fasting Glucose), a condition showing a 75g oral glucose tolerance test 2 h level
(glucose concentration of intravenous plasma) of less than 140 mg/dl is called IFG
(Impaired Fasting Glycemia).
[0094] The compound (I) can be also used as an agent for improving or an agent for the prophylaxis
or treatment of diabetes, borderline type, impaired glucose tolerance abnormality,
IFG (Impaired Fasting Glucose) and IFG (Impaired Fasting Glycemia), as determined
according to the above-mentioned diagnostic criteria, and further as a therapeutic
agent for hypertension of patients with hypertension of the level not less than the
above-mentioned diagnostic criteria (e.g., fasting blood sugar level of 126 mg/dl).
Moreover, the compound (I) can prevent progress of borderline type, impaired glucose
tolerance, IFG (Impaired Fasting Glucose) or IFG (Impaired Fasting Glycemia) into
diabetes.
[0095] The compound (I) is useful as an agent for the prophylaxis or treatment of metabolic
syndrome. Because patients with metabolic syndrome have an extreme high incidence
of cardiovascular diseases as compared to patients with single lifestyle-related disease,
the prophylaxis or treatment of metabolic syndrome is quite important to prevent cardiovascular
diseases.
Criteria for diagnosis of metabolic syndrome are announced by WHO in 1999, and by
NCEP in 2001. According to the criterion of WHO, patients with at least two of abdominal
obesity, dyslipidemia (high TG or low HDL) and hypertension in addition to hyperinsulinemia
or impaired glucose tolerance are diagnosed as metabolic syndrome (
World Health Organization: Definition, Diagnosis and Classification of Diabetes Mellitus
and Its Complications. Part I: Diagnosis and Classification of Diabetes Mellitus,
World Health Organization, Geneva, 1999). According to the criterion of Adult Treatment Panel III of National Cholesterol
Education Program, that is an indicator for managing ischemic heart diseases in America,
patients with at least three of abdominal obesity, high triglycerides, low HDL cholesterol,
hypertension and impaired glucose tolerance are diagnosed as metabolic syndrome (
National Cholesterol Education Program: Executive Summary of the Third Report of National
Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment
of High Blood Cholesterol in Adults (Adults Treatment Panel III). The Journal of the
American Medical Association, Vol. 285, 2486-2497, 2001).
The compound (I) can be used for treating patients of high blood pressure with metabolic
syndrome.
[0096] Since compound (I) has an anti-inflammatory action, it can be used as an anti-inflammatory
agent for preventing or treating inflammatory diseases. Examples of inflammatory diseases
include inflammatory diseases due to various diseases such as arthritis (e.g., chronic
rheumatoid arthritis, osteoarthritis, rheumatoid myelitis, gouty arthritis, synovitis),
asthma, allergic diseases, arteriosclerosis including atherosclerosis (aneurysm, coronary
atherosclerosis, cerebral arterial sclerosis, peripheral arterial sclerosis etc.),
digestive tract diseases such as inflammatory bowel diseases (e.g., Crohn's disease,
ulcerative colitis), diabetic complications (diabetic nerves disorder, diabetic vascular
disorder), atopic dermatitis, chronic obstructive pulmonary disease, systemic lupus
erythematosus, visceral inflammatory diseases (nephritis, hepatitis), autoimmune hemolytic
anemia, psoriasis, nervous degenerative diseases (e.g., Alzheimer's disease, Parkinson's
diseases, amyotrophic lateral sclerosis, AIDS encephalopathy), central nervous disorders
(e.g., cerebrovascular disorder such as cerebral hemorrhage and cerebral infarction,
head trauma, spinal damage, cerebral edema, multiple sclerosis), meningitis, angina,
cardiac infarction, congestive cardiac failure, vascular hypertrophy or occlusion
and organ disorders after intervention (percutaneous coronary angioplasty, stenting,
coronary angioscopy, intravascular ultrasound, intracoronary thrombolysis etc.), vascular
reocclusion and restenosis after bypass surgery, endothelial function disorder, other
circulatory diseases (intermittent claudication, obstructive peripheral circulatory
diturbance, arteriosclerosis obliterans, thromboangiitis obliterans, ischemic cerebral
circulatory disorder, Raynaud's disease, Berger disease), inflammatory ocular disease,
pulmonary sarcoidosis (e.g., chronic pneumonia, pulmonary silicosis, pulmonary sarcoidosis,
pulmonary tuberculosis), endometritis, toxemia (e.g., sepsis, septic shock, endotoxin
shock, gram negative sepsis, toxic shock syndrome), cachexia (e.g., cachexia due to
infection, carcinomatous cachexia, cachexia due to acquired immunodeficiency syndrome),
cancer, Addison's disease, Creutzfeldt-Jakob disease, virus infection (e.g., infection
of virus such as cytomegalovirus, influenza virus, herpes virus etc.), disseminated
intravascular coagulation and the like. Since compound (I) has an analgesis action,
it can also be used as an analgesic agent for preventing or treating pain. Examples
of pain diseases include acute pain due to inflammation, pain associated with chronic
inflammation, pain associated with acute inflammation, pain after operation (pain
of incisional, deep pain, organ pain, chronic pain after operation etc.), muscular
pain (muscular pain associated with chronic pain disease, shoulder stiffness etc.),
arthralgia, toothache, gnathicarthralgia, headache (migraine, catatonic headache,
headache associated with fever, headache associated hypertension), organ pain (cardiac
pain, angina pain, abdominal pain, renal pain, ureterane pain, bladder pain), pain
in obstetrics area (mittelschmerz, dysmenorrheal, labor pain), neuralgia (disc hernia,
nerve root pain, neuralgia after herpes zoster, trigeminal neuralgia), carcinomatous
pain, reflex sympathetic atrophy, complex local pain syndrome, and the like. The compound
(I) is effective for alleviating various pains such as nervous pain, carcinomatous
pain and inflammatory pain directly and rapidly, and exhibits a particularly superior
analgesic effect for patients and pathologies (e.g., hypertension, diabetes, etc.
and their complications and the like) in which a pain sense threshold has been lowered.
Compound (I) is particulary useful as an analgesic agent for pain associated with
chronic inflammation or headache associated with hypertension, or a prophylactic or
therapeutic drug for inflammatory diseases or pain caused by (1) arteriosclerosis
including atherosclerosis, (2) vascular hypertrophy, vascular occlusion and organ
disorders after intervention, (3) vascular reocclusion and restenosis after bypass
surgery, endothelial function disorder (4) intermittent claudication, (5) obstructive
peripheral circulatory disturbance or (6) arteriosclerosis obliterans.
When compound (I) is combined with a calcium antagonist, the solid preparation of
the present invention is useful as a drug for the prophylaxis or treatment of the
above-mentioned diseases (preferably, a prophylactic or therapeutic drug for hypertension,
cardiac failure, diabetic nephropathy or arteriosclerosis, more preferably, a prophylactic
or therapeutic drug for hypertension), enables to reduce the doses of compound (I)
and a calcium antagonist when used alone, and suppresses side effects.
[0097] The compound (I) can be used in combination with one or more different kinds of medicaments
(hereinafter sometimes to be abbreviated as "concomitant drug").
[0098] In a specific example, compound (I) can be used in combination with one or more kinds
of drugs (concomitant drug) selected from therapeutic agents for diabetes, therapeutic
agents for diabetic complications, therapeutic agents for hyperlipidemia, antihypertensive
agents, antiobestic agents, diuretics, antithrombotic agents and the like.
[0099] Here, as the therapeutic agent for diabetes, for example, insulin preparations (e.g.,
animal insulin preparations extracted from the pancreas of bovine or swine; human
insulin preparations genetically synthesized using
Escherichia coli or yeast; zinc insulin; protamine zinc insulin; fragment or derivative of insulin
(e.g., INS-1), oral insulin preparation), insulin sensitizers (e.g., pioglitazone
or a salt thereof (preferably, hydrochloride), rosiglitazone or a salt thereof (preferably,
maleate), Metaglidasen, AMG-131, Balaglitazone, MBX-2044, Rivoglitazone, Aleglitazar,
Chiglitazar, Lobeglitazone, PLX-204, PN-2034, GFT-505, THR-0921, compounds described
in
WO2007/013694,
WO2007/018314,
WO2008/093639 or
WO2008/099794), α-glucosidase inhibitors (e.g., voglibose, acarbose, miglitol, emiglitate), biguanides
(e.g., metformin, buformin or a salt thereof (e.g., hydrochloride, fumarate, succinate)),
insulin secretagogues (e.g., sulfonylurea (e.g., tolbutamide, glibenclamide, gliclazide,
chlorpropamide, tolazamide, acetohexamide, glyclopyramide, glimepiride, glipizide,
glybuzole), repaglinide, nateglinide, mitiglinide or calcium salt hydrate thereof),
dipeptidyl peptidase IV inhibitors (e.g., Alogliptin or a salt thereof (preferably,
benzoate), Vildagliptin, Sitagliptin, Saxagliptin, BI1356, GRC8200, MP-513, PF-00734200,
PHX1149, SK-0403, ALS2-0426, TA-6666, TS-021, KRP-104, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile
or a salt thereof), β3 agonists (e.g., N-5984), GPR40 agonists (e.g., compounds described
in
WO2004/041266,
WO2004/106276,
WO2005/063729,
WO2005/063725,
WO2005/087710,
WO2005/095338,
WO2007/013689 or
WO2008/001931), GLP-1 receptor agonists (e.g., GLP-1, GLP-1MR agent, Liraglutide, Exenatide, AVE-0010,
BIM-51077, Aib(8,35)hGLP-1(7,37)NH2, CJC-1131, Albiglutide), amylin agonists (e.g.,
pramlintide), phosphotyrosine phosphatase inhibitors (e.g., sodium vanadate), gluconeogenesis
inhibitors (e.g., glycogen phosphorylase inhibitors, glucose-6-phosphatase inhibitors,
glucagon antagonists, FBPase inhibitors), SGLT2 (sodium-glucose cotransporter 2) inhibitors
(e.g., Depagliflozin, AVE2268, TS-033, YM543, TA-7284, Remogliflozin, ASP1941), SGLT1
inhibitors, 11β-hydroxysteroid dehydrogenase inhibitors (e.g., BVT-3498, INCB-13739),
adiponectin or agonist thereof, IKK inhibitors (e.g., AS-2868), leptin resistance
improving drugs, somatostatin receptor agonists, glucokinase activators (e.g., Piragliatin,
AZD1656, AZD6370, TTP-355, compounds described in
WO2006/112549,
WO2007/028135,
WO2008/047821,
WO2008/050821,
WO2008/136428 or
WO2008/156757), GIP (Glucose-dependent insulinotropic peptide), GPR119 agonists (e.g., PSN821),
FGF21, FGF analogue and the like can be mentioned.
[0100] As the therapeutic agent for diabetic complications, aldose reductase inhibitors
(e.g., tolrestat, epalrestat, zopolrestat, fidarestat, CT-112, ranirestat (AS-3201),
lidorestat), neurotrophic factor and increasing agents thereof (e.g., NGF, NT-3, BDNF,
neurotrophic production/secretion promoting agent described in
WO01/14372 (e.g., 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-[3-(2-methylphenoxy)propyl]oxazole),
compounds described in
WO2004/039365), PKC inhibitors (e.g., ruboxistaurin mesylate), AGE inhibitors (e.g., ALT946, N-phenacylthiazolium
bromide (ALT766), EXO-226, Pyridorin, pyridoxamine), GABA receptor agonists (e.g.,
gabapentin, pregabalin), serotonin and norepinephrine reuptake inhibitors (e.g., duloxetine),
sodium channel inhibitors (e.g., lacosamide), active oxygen scavengers (e.g., thioctic
acid), cerebral vasodilators (e.g., tiapuride, mexiletine), somatostatin receptor
agonists (e.g., BIM23190), apoptosis signal regulating kinase-1 (ASK-1) inhibitors
and the like can be mentioned.
[0101] As the therapeutic agent for hyperlipidemia, HMG-CoA reductase inhibitors (e.g.,
pravastatin, simvastatin, lovastatin, atorvastatin, fluvastatin, rosuvastatin, pitavastatin
or a salt thereof (e.g., sodium salt, calcium salt)), squalene synthase inhibitors
(e.g., compounds described in
WO97/10224, for example, N-[[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-acetic
acid), fibrate compounds (e.g., bezafibrate, clofibrate, simfibrate, clinofibrate),
anion exchange resin (e.g., colestyramine), probucol, nicotinic acid drugs (e.g.,
nicomol, niceritrol, niaspan), ethyl icosapentate, phytosterol (e.g., soysterol, gamma
oryzanol (y-oryzanol)), cholesterol absorption inhibitors (e.g., zechia), CETP inhibitors
(e.g., dalcetrapib, anacetrapib), ω-3 fatty acid preparations (e.g., ω-3-acid ethyl
esters 90) and the like can be mentioned.
[0102] As the antihypertensive agent, angiotensin converting enzyme inhibitors (e.g., captopril,
enalapril, delapril and the like), angiotensin II antagonists (e.g., candesartan cilexetil,
candesartan, losartan, losartan potassium, eprosartan, valsartan, telmisartan, irbesartan,
tasosartan, olmesart, olmesartan medoxomil, azilsartan and the like), a calcium antagonists
(e.g., manidipine, nifedipine, amlodipine, efonidipine, nicardipine, amlodipine, cilnidipine
and the like, β blockers (e.g., metoprolol, atenolol, propranolol, carvedilol, pindolol
and the like), clonidine and the like can be mentioned.
[0103] As the antiobesity agent, monoamine uptake inhibitors (e.g., phentermine, sibutramine,
mazindol, fluoxetine, tesofensine), serotonin 2C receptor agonists (e.g., lorcaserin),
serotonin 6 receptor antagonists, histamine H3 receptor, GABA-regulating drugs (e.g.,
topiramate), neuropeptide Y antagonists (e.g., velneperit), cannabinoid receptor antagonists
(e.g., rimonabant, taranabant), ghrelinant agonists, ghrelin receptor antagonists,
ghrelin acylation enzyme inhibitors, opioid receptor antagonists (e.g., GSK-1521498),
orexin receptor antagonists, melanocortin 4 receptor agonists, 11β-hydroxysteroid
dehydrogenase inhibitors (e.g., AZD-4017), pancreatic lipase inhibitors (e.g., orlistat,
cetilistat), β3 agonists (e.g., N-5984), diacylglycerol acyltransferase 1 (DGAT1)
inhibitors, acetyl CoA carboxylase (ACC) inhibitors, steaoryl-CoA desaturase inhibitors,
microsomal triglyceride transfer protein inhibitors (e.g., R-256918), Na-glucose cotransporter
inhibitors (e.g., JNJ-28431754, remogliflozin), NFκB inhibitors (e.g., HE-3286), PPAR
agonists (e.g., GFT-505, DRF-11605), phosphotyrosine phosphatase inhibitors (e.g.,
sodium vanadate, Trodusquemin), GPR119 agonists (e.g., PSN-821), glucokinase activators
(e.g., AZD-1656), leptin, leptin derivatives (e.g., metreleptin), CNTF (ciliary neurotrophic
factor), BDNF (brain-derived neurotrophic factor), cholecystokinin agonists, glucagon-like
peptide-1 (GLP-1) preparations (e.g., animal GLP-1 preparations extracted from the
pancreas of bovine or swine; human GLP-1 preparations genetically synthesized using
Escherichia coli or yeast; fragment or derivative of GLP-1 (e.g., exenatide, liraglutide)), amylin
preparations (e.g., pramlintide, AC-2307), neuropeptide Y agonists (e.g., PYY3-36,
derivative of PYY3-36, obinepitide, TM-30339, TM-30335), oxyntomodulin preparations;
FGF21 preparations (e.g., animal FGF21 preparations extracted from the pancreas of
bovine or swine; human FGF21 preparations genetically synthesized using
Escherichia coli or yeast; fragment or derivative of FGF21)), feeding deterrents (e.g., P-57) and
the like can be mentioned.
[0104] As the diuretic, for example, xanthine derivatives (e.g., theobromine sodium salicylate,
theobromine calcium salicylate and the like), thiazide preparations (e.g., ethiazide,
cyclopenthiazide, trichloromethyazide, hydrochlorothiazide, hydroflumethiazide, benzylhydrochlorothiazide,
penfluthiazide, poly 5 thiazide, methyclothiazide and the like), antialdosterone preparations
(e.g., spironolactone, triamterene and the like), carbonic anhydrase inhibitors (e.g.,
acetazolamide and the like), chlorobenzenesulfonamide agents (e.g., chlortalidone,
mefruside, indapamide and the like), azosemide, isosorbide, ethacrynic acid, piretanide,
bumetanide, furosemide and the like can be mentioned.
[0105] As the antithrombotic agents, for example, heparin (e.g., heparin sodium, heparin
calcium, enoxaparin sodium, dalteparin sodium), warfarin (e.g., warfarin potassium),
anti-thrombin drugs (e.g., aragatroban, dabigatran), FXa inhibitors (e.g., rivaroxaban,
apixaban, edoxaban, YM150, compounds described in
WO02/06234,
WO2004/048363,
WO2005/030740,
WO2005/058823 or
WO2005/113504), thrombolytic agents (e.g., urokinase, tisokinase, alteplase, nateplase, monteplase,
pamiteplase), platelet aggregation inhibitors (e.g., ticlopidine hydrochloride, clopidogrel,
prasugrel, E5555, SHC530348, cilostazol, ethyl icosapentate, beraprost sodium, sarpogrelate
hydrochloride) and the like can be mentioned.
[0106] When the solid preparation of the present invention and a concomitant drug are used
in combination, the administration period thereof is not limited, and they may be
administered simultaneously or in a staggered manner to the administration subject.
Moreover, the solid preparation of the present invention and a concomitant drug may
be administered as separate preparations, or as a single preparation containing the
solid preparation of the present invention and a concomitant drug.
[0107] The dose of the concomitant drug can be appropriately determined based on the dose
employed in clinical situations of each drug. The mixing ratio of the solid preparation
of the present invention and a concomitant drug can be appropriately determined depending
on the administration subject, administration route, target disease, symptom, combination
and the like. When the subject of administration is human, for example, a concomitant
drug can be used in 0.01 to 100 parts by weight relative to 1 part by weight of the
solid preparation of the present invention.
Using a concomitant drug in this way, superior effects of
1) an effect of enhancing the action of compound (I) or a concomitant drug (synergistic
effect of medicament actions);
2) an effect of reducing the dose of compound (I) or a concomitant drug (medicament
dose-reducing effect as compared to single administration);
3) an effect of reducing the secondary action of compound (I) or a concomitant drug;
and the like can be obtained.
[0108] The present invention provides a method of stabilizing a compound represented by
the formula (I) or a salt thereof and a calcium antagonist in a solid preparation
comprising the compound represented by the formula (I) or a salt thereof, and a calcium
antagonist, which method comprising adding a pH control agent. According to the stabilizing
method of the present invention, compound (I) in the solid preparation can be significantly
stabilized. In addition, the present invention also provides a method of improving
dissolution of a compound represented by the formula (I) or a salt thereof from a
solid preparation comprising the compound represented by the formula (I) or a salt
thereof, and a calcium antagonist, which method comprising adding a pH control agent.
According to the improvement method of dissolution property in the present invention,
the dissolution property of compound (I) from a solid preparation can be significantly
improved.
[0109] The present invention is explained in more detail in the following by referring to
Preparation Examples, Reference Examples, Comparative Examples and Experimental Examples,
which are not to be construed as limitative.
As the ingredients (additives) other than the active ingredient in the pharmaceutical
preparations described in the Preparation Examples, Reference Examples and Comparative
Examples, compatible products of the Japanese Pharmacopoeia, the Japanese Pharmaceutical
Codex or Japanese Pharmaceutical Excipients were used.
EXAMPLES
Formulation Example 1
[0110]
(1) Hydroxypropylcellulose (5124 g) was dissolved in purified water (80280 g) to give
binder liquid I. Amlodipine besylate (2984 g), mannitol (55840 g) and crystalline
cellulose (3870 g) were uniformly mixed in a fluid bed granulator (WSG-60, POWREX
CORPORATION), and granulated by spraying the binder liquid I (38700 g) and then dried
to give granules. A part of the obtained granules was milled in a powermill grinder
(P-7S, Showa Chemical Machinery) using 1.5 mmφ punching screen to give milled granules.
Crystalline cellulose (7200 g), crospovidone (3600 g), magnesium stearate (720 g)
and the milled granules (60480 g) were mixed in a tumbler mixer (TM-400S, Showa Chemical
Machinery) to give mixed granules A.
(2) Sodium hydroxide (405.8 g) and fumaric acid (1176 g) were dissolved in purified
water (38230 g) to give a buffer solution. Hydroxypropylcellulose (3018 g) was dissolved
in purified water (47280 g) to give binder liquid II. Compound A (20060 g), mannitol
(40860 g), crystalline cellulose (4230 g) were uniformly mixed in a fluid bed granulator
(WSG-60, POWREX CORPORATION), and granulated by spraying the buffer solution (31810
g) and further the binder liquid II (42300 g), and dried to give granules. A part
of the obtained granules were milled in a powermill grinder (P-7S, Showa Chemical
Machinery) using 1.5 mmφ punching screen to give milled granules. Crystalline cellulose
(7380 g), crospovidone (5535 g), magnesium stearate (738 g) and the milled granules
(60150 g) were mixed in a tumbler mixer (TM-400S, Showa Chemical Machinery) to give
mixed granules B.
(3) The mixed granules A (180 mg) and the mixed granules B (90 mg) were tableted in
the form of bi-layer by a rotary tableting machine (AQUA 08242L2JI, Kikusui Seisakusho,
Ltd.) with 8.5 mmφ punch (tableting pressure 8 KN, weight per tablet: 270 mg) to give
plain tablets.
(4) Hydroxypropylmethylcellulose (468 g) and talc (72 g) were dissolved and dispersed
in purified water (4320 g) to give dispersion liquid I. Titanium oxide (54 g) and
iron oxide (6 g) were dispersed in purified water (900 g) to give dispersion liquid
II. The dispersion liquid I was mixed with the dispersion liquid II and purified water
(180 g) to give a coating dispersion. Using a pan coating machine (DRC-650, POWREX
CORPORATION), the coating dispersion was sprayed until the weight of the plain tablets
obtained in (3) increased by 10 mg per tablet, whereby film-coated tablets having
the following composition were obtained. Then, the film-coated tablets were dried
under the reduced pressure at 40°C for 18 hr.
[0111]
composition of preparation (per 280 mg) |
amlodipine besylate |
6.94 mg |
mannitol |
129.86 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
9 mg |
magnesium stearate |
1.8 mg |
compound A |
21.34 mg |
mannitol |
43.465 mg |
crystalline cellulose |
4.5 mg |
sodium hydroxide |
0.345 mg |
fumaric acid |
1 mg |
hydroxypropylcellulose |
2.7 mg |
crystalline cellulose |
9 mg |
crospovidone |
6.75 mg |
magnesium stearate |
0.9 mg |
hydroxypropylmethylcellulose |
7.8 mg |
talc |
1.2 mg |
titanium oxide |
0.9 mg |
iron oxide |
0.1 mg |
total |
280 mg |
Formulation Example 2
[0112]
(1) Hydroxypropylcellulose (5124 g) was dissolved in purified water (80280 g) to give
binder liquid I. Amlodipine besylate (5964 g), mannitol (52860 g) and crystalline
cellulose (3870 g) were uniformly mixed in a fluid bed granulator (WSG-60, POWREX
CORPORATION), and granulated by spraying the binder liquid I (38700 g) and then dried
to give granules. A part of the obtained granules was milled in a powermill grinder
(P-7S, Showa Chemical Machinery) using 1.5 mmφ punching screen to give milled granules.
Crystalline cellulose (7200 g), crospovidone (3600 g), magnesium stearate (720 g)
and the milled granules (60480 g) were mixed in a tumbler mixer (TM-400S, Showa Chemical
Machinery) to give mixed granules A.
(2) Sodium hydroxide (405.8 g) and fumaric acid (1176 g) were dissolved in purified
water (38230 g) to give a buffer solution. Hydroxypropylcellulose (3018 g) was dissolved
in purified water (47280 g) to give binder liquid II. Compound A (20060 g), mannitol
(40860 g) and crystalline cellulose (4230 g) were uniformly mixed in a fluid bed granulator
(WSG-60, POWREX CORPORATION) and granulated by spraying the buffer solution (31810
g) and then the binder liquid II (42300 g), and then dried to give granules. A part
of the obtained granules was milled in a powermill grinder (P-7S, Showa Chemical Machinery)
using 1.5 mmφ punching screen to give milled granules. Crystalline cellulose (7380
g), crospovidone (5535 g), magnesium stearate (738 g) and the milled granules (58680
g) were mixed in a tumbler mixer (TM-400S, Showa Chemical Machinery) to give mixed
granules B.
(3) The mixed granules A (180 mg) and the mixed granules B (90 mg) were tableted in
the form of a bi-layer by a rotary tableting machine (AQUA 08242L2JI, Kikusui Seisakusho,
Ltd.) with 8.5 mmφ punch (tableting pressure 8 KN, weight per tablet: 270 mg) to give
plain tablets.
(4) Hydroxypropylmethylcellulose (468 g) and talc (72 g) were dissolved and dispersed
in purified water (4320 g) to give dispersion liquid I. Titanium oxide (54 g) and
iron oxide (6 g) were dispersed in purified water (900 g) to give dispersion liquid
II. The dispersion liquid I was mixed with the dispersion liquid II and purified water
(180 g) to give a coating dispersion. Using a pan coating machine (DRC-650, POWREX
CORPORATION), the coating dispersion was sprayed until the weight of the plain tablets
obtained in (3) increased by 10 mg per tablet, whereby film-coated tablets having
the following composition were obtained. Then, the film-coated tablets were dried
under the reduced pressure at 40°C for 18 hr.
[0113]
composition of preparation (per 280 mg) |
amlodipine besylate |
13.87 mg |
mannitol |
122.93 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
9 mg |
magnesium stearate |
1.8 mg |
compound A |
21.34 mg |
mannitol |
43.465 mg |
crystalline cellulose |
4.5 mg |
sodium hydroxide |
0.345 mg |
fumaric acid |
1 mg |
hydroxypropylcellulose |
2.7 mg |
crystalline cellulose |
9 mg |
crospovidone |
6.75 mg |
magnesium stearate |
0.9 mg |
hydroxypropylmethylcellulose |
7.8 mg |
talc |
1.2 mg |
titanium oxide |
0.9 mg |
iron oxide |
0.1 mg |
total |
280 mg |
Formulation Example 3
[0114]
(1) Hydroxypropylcellulose (5124 g) was dissolved in purified water (80280 g) to give
binder liquid I. Amlodipine besylate (2984 g), mannitol (55840 g) and crystalline
cellulose (3870 g) were uniformly mixed in a fluid bed granulator (WSG-60, POWREX
CORPORATION), and granulated by spraying the binder liquid I (38700 g) and then dried
to give granules. A part of the obtained granules was milled in a powermill grinder
(P-7S, Showa Chemical Machinery) with 1.5 mmφ punching screen to give milled granules.
Crystalline cellulose (7200 g), crospovidone (3600 g), magnesium stearate (720 g)
and the milled granules (60480 g) were mixed in a tumbler mixer (TM-400S, Showa Chemical
Machinery) to give mixed granules A.
(2) Sodium hydroxide (405.8 g) and fumaric acid (1176 g) were dissolved in purified
water (38230 g) to give a buffer solution. Hydroxypropylcellulose (3018 g) was dissolved
in purified water (47280 g) to give binder liquid II. Compound A (20060 g), mannitol
(40860 g) and crystalline cellulose (4230 g) were uniformly mixed in a fluid bed granulator
(WSG-60, POWREX CORPORATION), and granulated by spraying the buffer solution(31810
g) and then the binder liquid II (42300 g), and then dried to give granules. A part
of the obtained granules was milled in a powermill grinder (P-7S, Showa Chemical Machinery)
with 1.5 mmφ punching screen to give milled granules. Crystalline cellulose (7380
g), crospovidone (5535 g), magnesium stearate (738 g) and the milled granules (60150
g) were mixed in a tumbler mixer (TM-400S, Showa Chemical Machinery) to give mixed
granules B.
(3) The mixed granules A (180 mg) and the mixed granules B (360 mg) were tableted
in the form of bi-layer by a rotary tableting machine (AQUA 08242L2JI, Kikusui Seisakusho,
Ltd.) with a punch having a major axis 14 mm, a miner axis 8 mm (tableting pressure
9 KN, weight per tablet: 540 mg) to give plain tablets.
(4) Hydroxypropylmethylcellulose (468 g) and talc (72 g) were dissolved and dispersed
in purified water (4320 g) to give dispersion liquid I. Titanium oxide (54 g) and
iron oxide (6 g) were dispersed in purified water (900 g) to give dispersion liquid
II. The dispersion liquid I was mixed with the dispersion liquid II and purified water
(180 g) to give a coating dispersion. Using a pan coating machine (DRC-650, POWREX
CORPORATION), the coating dispersion was sprayed until the weight of the plain tablets
obtained in (3) increased by 20 mg per tablet, whereby film-coated tablets having
the following composition were obtained. Then, the film-coated tablets were dried
under the reduced pressure at 40°C for 18 hr.
[0115]
composition of preparation (per 560 mg) |
amlodipine besylate |
6.94 mg |
mannitol |
129.86 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
9 mg |
magnesium stearate |
1.8 mg |
compound A |
85.36 mg |
mannitol |
173.86 mg |
crystalline cellulose |
18 mg |
sodium hydroxide |
1.38 mg |
fumaric acid |
4 mg |
hydroxypropylcellulose |
10.8 mg |
crystalline cellulose |
36 mg |
crospovidone |
27 mg |
magnesium stearate |
3.6 mg |
hydroxypropylmethylcellulose |
15.6 mg |
talc |
2.4 mg |
titanium oxide |
1.8 mg |
iron oxide |
0.2 mg |
total |
560 mg |
Formulation Example 4
[0116]
(1) Hydroxypropylcellulose (5124 g) was dissolved in purified water (80280 g) to give
binder liquid I. Amlodipine besylate (5964 g), mannitol (52860 g) and crystalline
cellulose (3870 g) were uniformly mixed in a fluid bed granulator (WSG-60, POWREX
CORPORATION), and granulated by spraying the binder liquid I (38700 g) and then dried
to give granules. A part of the obtained granules was milled in a powermill grinder
(P-7S, Showa Chemical Machinery) with 1.5 mmφ punching screen to give milled granules.
Crystalline cellulose (7200 g), crospovidone (3600 g), magnesium stearate (720 g)
and the milled granules (60480 g) were mixed in a tumbler mixer (TM-400S, Showa Chemical
Machinery) to give mixed granules A.
(2) Sodium hydroxide (405.8 g) and fumaric acid (1176 g) were dissolved in purified
water (38230 g) to give a buffer solution. Hydroxypropylcellulose (3018 g) was dissolved
in purified water (47280 g) to give binder liquid II. Compound A (20060 g), mannitol
(40860 g) and crystalline cellulose (4230 g) were uniformly mixed in a fluid bed granulator
(WSG-60, POWREX CORPORATION), and granulated by spraying the buffer solution (31810
g) and then the binder liquid II (42300 g), and then dried to give granules. A part
of the obtained granules was milled in a powermill grinder (P-7S, Showa Chemical Machinery)
with 1.5 mmφ punching screen to give milled granules. Crystalline cellulose (7380
g), crospovidone (5535 g), magnesium stearate (738 g) and the milled granules (60150
g) were mixed in a tumbler mixer (TM-400S, Showa Chemical Machinery) to give mixed
granules B.
(3) The mixed granules A (180 mg) and the mixed granules B (360 mg) were tableted
in the form of a bi-layer by a rotary tableting machine (AQUA 08242L2JI, Kikusui Seisakusho,
Ltd.) with a punch having a major axis 14 mm, a miner axis 8 mm (tableting pressure
9 kN, weight per tablet: 540 mg) to give plain tablets.
(4) Hydroxypropylmethylcellulose (468 g) and talc (72 g) were dissolved and dispersed
in purified water (4320 g) to give dispersion liquid I. Titanium oxide (54 g) and
iron oxide (6 g) were dispersed in purified water (900 g) to give dispersion liquid
II. The dispersion liquid I was mixed with the dispersion liquid II and purified water
(180 g) to give a coating dispersion. Using a pan coating machine (DRC-650, POWREX
CORPORATION), the coating dispersion was sprayed until the weight of the plain tablets
obtained in (3) increased by 20 mg per tablet, whereby film-coated tablets having
the following composition were obtained. Then, the film-coated tablets were dried
under the reduced pressure at 40°C for 18 hr.
[0117]
composition of preparation (per 560 mg) |
amlodipine besylate |
13.87 mg |
mannitol |
122.93 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
9 mg |
magnesium stearate |
1.8 mg |
compound A |
85.36 mg |
mannitol |
173.86 mg |
crystalline cellulose |
18 mg |
sodium hydroxide |
1.38 mg |
fumaric acid |
4 mg |
hydroxypropylcellulose |
10.8 mg |
crystalline cellulose |
36 mg |
crospovidone |
27 mg |
magnesium stearate |
3.6 mg |
hydroxypropylmethylcellulose |
15.6 mg |
talc |
2.4 mg |
titanium oxide |
1.8 mg |
iron oxide |
0.2 mg |
total |
560 mg |
Formulation Example 5
[0118]
(1) Hydroxypropylcellulose (5124 g) was dissolved in purified water (80280 g) to give
binder liquid I. Amlodipine besylate (2984 g), mannitol (55840 g) and crystalline
cellulose (3870 g) were uniformly mixed in a fluid bed granulator (WSG-60, POWREX
CORPORATION), and granulated by spraying the binder liquid I (38700 g) and then dried
to give granules. A part of the obtained granules was milled in a powermill grinder
(P-7S, Showa Chemical Machinery) with 1.5 mmφ punching screen to give milled granules
A.
(2) Sodium hydroxide (405.8 g) and fumaric acid (1176 g) were dissolved in purified
water (38230 g) to give a buffer solution. Hydroxypropylcellulose (3018 g) was dissolved
in purified water (47280 g) to give binder liquid II. Compound A (20060 g), mannitol
(40860 g) and crystalline cellulose (4230 g) were uniformly mixed in a fluid bed granulator
(WSG-60, POWREX CORPORATION) and granulated by spraying the buffer solution (31810
g) and then the binder liquid II (42300 g), and then dried to give granules. A part
of the obtained granules was milled in a powermill grinder (P-7S, Showa Chemical Machinery)
with 1.5 mmφ punching screen to give milled granules B.
(3) Crystalline cellulose (1620 g), crospovidone (945 g), magnesium stearate (162
g), the milled granules A (9072 g) and milled granules B (4401 g) were mixed in a
tumbler mixer (TM-100, Showa Chemical Machinery) to give mixed granules.
(4) The mixed granules were tableted by a rotary tableting machine (AQUA 512SS2AI,
Kikusui Seisakusho, Ltd.) with 8.5 mmφ punch (tableting pressure: 7 KN, weight per
tablet: 270 mg) to give plain tablets.
(5) Hydroxypropylmethylcellulose (468 g) and talc (72 g) were dissolved and dispersed
in purified water (4320 g) to give dispersion liquid I. Titanium oxide (54 g) and
iron oxide (6 g) were dispersed in purified water (900 g) to give dispersion liquid
II. The dispersion liquid I was mixed with the dispersion liquid II and purified water
(180 g) to give a coating dispersion. Using a pan coating machine (DRC-650, POWREX
CORPORATION), the coating dispersion was sprayed until the weight of the plain tablets
obtained in (4) increased by 10 mg per tablet, whereby film-coated tablets having
the following composition were obtained. Then, the film-coated tablets were dried
under reduced the pressure at 40°C for 18 hr.
[0119]
composition of preparation (per 280 mg) |
amlodipine besylate |
6.94 mg |
mannitol |
129.86 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
compound A |
21.34 mg |
mannitol |
43.465 mg |
crystalline cellulose |
4.5 mg |
sodium hydroxide |
0.345 mg |
fumaric acid |
1 mg |
hydroxypropylcellulose |
2.7 mg |
crystalline cellulose |
27 mg |
crospovidone |
15.75 mg |
magnesium stearate |
2.7 mg |
hydroxypropylmethylcellulose |
7.8 mg |
talc |
1.2 mg |
titanium oxide |
0.9 mg |
iron oxide |
0.1 mg |
total |
280 mg |
Formulation Example 6
[0120]
(1) Hydroxypropylcellulose (5124 g) was dissolved in purified water (80280 g) to give
binder liquid I. Amlodipine besylate (5964 g), mannitol (52860 g) and crystalline
cellulose (3870 g) were uniformly mixed in a fluid bed granulator (WSG-60, POWREX
CORPORATION), and granulated by spraying the binder liquid I (38700 g) and then dried
to give granules. A part of the obtained granules was milled in a powermill grinder
(P-7S, Showa Chemical Machinery) with 1.5 mmφ punching screen to give milled granules
A.
(2) Sodium hydroxide (405.8 g) and fumaric acid (1176 g) were dissolved in purified
water (38230 g) to give a buffer solution. Hydroxypropylcellulose (3018 g) was dissolved
in purified water (47280 g) to give binder liquid II. Compound A (20060 g), mannitol
(40860 g) and crystalline cellulose (4230 g) were uniformly mixed in a fluid bed granulator
(WSG-60, POWREX CORPORATION) and granulated by spraying the buffer solution (31810
g) and then the binder liquid II (42300 g), and then dried to give granules. A part
of the obtained granules was milled in a powermill grinder (P-7S, Showa Chemical Machinery)
with 1.5 mmφ punching screen to give milled granules B.
(3) Crystalline cellulose (1620 g), crospovidone (945 g), magnesium stearate (162
g), the milled granules A (9072 g) and milled granules B (4401 g) were mixed in a
tumbler mixer (TM-60S, Showa Chemical Machinery) to give mixed granules.
(4) The mixed granules were tableted by a rotary tableting machine (AQUA 512SS2AI,
Kikusui Seisakusho, Ltd.) with 8.5 mmφ punch (tableting pressure: 7 KN, weight per
tablet: 270 mg) to give plain tablets.
(5) Hydroxypropylmethylcellulose (468 g) and talc (72 g) were dissolved and dispersed
in purified water (4320 g) to give dispersion liquid I. Titanium oxide (54 g) and
iron oxide (6 g) were dispersed in purified water (900 g) to give dispersion liquid
II. The dispersion liquid I was mixed with the dispersion liquid II and purified water
(180 g) to give a coating dispersion. Using a pan coating machine (DRC-650, POWREX
CORPORATION), the coating dispersion was sprayed until the weight of the plain tablets
obtained in (4) increased by 10 mg per tablet, whereby film-coated tablets having
the following composition were obtained. Then, the film-coated tablets were dried
under the reduced pressure at 40°C for 18 hr.
[0121]
composition of preparation (per 280 mg) |
amlodipine besylate |
13.87 mg |
mannitol |
122.93 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
compound A |
21.34 mg |
mannitol |
43.465 mg |
crystalline cellulose |
4.5 mg |
sodium hydroxide |
0.345 mg |
fumaric acid |
1 mg |
hydroxypropylcellulose |
2.7 mg |
crystalline cellulose |
27 mg |
crospovidone |
15.75 mg |
magnesium stearate |
2.7 mg |
hydroxypropylmethylcellulose |
7.8 mg |
talc |
1.2 mg |
titanium oxide |
0.9 mg |
iron oxide |
0.1 mg |
total |
280 mg |
Formulation Example 7
[0122]
(1) Hydroxypropylcellulose (5124 g) was dissolved in purified water (80280 g) to give
binder liquid I. Amlodipine besylate (2984 g), mannitol (55840 g) and crystalline
cellulose (3870 g) were uniformly mixed in a fluid bed granulator (WSG-60, POWREX
CORPORATION), and granulated by spraying the binder liquid I (38700 g) and then dried
to give granules. A part of the obtained granules was milled in a powermill grinder
(P-7S, Showa Chemical Machinery) with 1.5 mmφ punching screen to give milled granules
A.
(2) Sodium hydroxide (405.8 g) and fumaric acid (1176 g) were dissolved in purified
water (38230 g) to give a buffer solution. Hydroxypropylcellulose (3018 g) was dissolved
in purified water (47280 g) to give binder liquid II. Compound A (20060 g), mannitol
(40860 g) and crystalline cellulose (4230 g) were uniformly mixed in a fluid bed granulator
(WSG-60, POWREX CORPORATION) and granulated by spraying the buffer solution (31810
g) and then the binder liquid II (42300 g), and then dried to give granules. A part
of the obtained granules was milled in a powermill grinder (P-7S, Showa Chemical Machinery)
with 1.5 mmφ punching screen to give milled granules B.
(3) Crystalline cellulose (1620 g), crospovidone (1080 g), magnesium stearate (162
g), the milled granules A (4536 g) and milled granules B (8802 g) were mixed in a
tumbler mixer (TM-60S, Showa Chemical Machinery) to give mixed granules.
(4) The mixed granules were tableted by a rotary tableting machine (AQUA 512SS2AI,
Kikusui Seisakusho, Ltd.) with a punch having a major axis 14 mm, a miner axis 8 mm
(tableting pressure: 9 KN, weight per tablet: 540 mg) to give plain tablets.
(5) Hydroxypropylmethylcellulose (468 g) and talc (72 g) were dissolved and dispersed
in purified water (4320 g) to give dispersion liquid I. Titanium oxide (54 g) and
iron oxide (6 g) were dispersed in purified water (900 g) to give dispersion liquid
II. The dispersion liquid I was mixed with the dispersion liquid II and purified water
(180 g) to give a coating dispersion. Using a pan coating machine (DRC-650, POWREX
CORPORATION), the coating dispersion was sprayed until the weight of the plain tablets
obtained in (4) increased by 20 mg per tablet, whereby film-coated tablets having
the following composition were obtained. Then, the film-coated tablets were dried
under the reduced pressure at 40°C for 18 hr.
[0123]
composition of preparation (per 560 mg) |
amlodipine besylate |
6.94 mg |
mannitol |
129.86 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
compound A |
85.36 mg |
mannitol |
173.86 mg |
crystalline cellulose |
18 mg |
sodium hydroxide |
1.38 mg |
fumaric acid |
4 mg |
hydroxypropylcellulose |
10.8 mg |
crystalline cellulose |
54 mg |
crospovidone |
36 mg |
magnesium stearate |
5.4 mg |
hydroxypropylmethylcellulose |
15.6 mg |
talc |
2.4 mg |
titanium oxide |
1.8 mg |
iron oxide |
0.2 mg |
total |
560 mg |
Formulation Example 8
[0124]
(1) Hydroxypropylcellulose (5124 g) was dissolved in purified water (80280 g) to give
binder liquid I. Amlodipine besylate (5964 g), mannitol (52860 g) and crystalline
cellulose (3870 g) were uniformly mixed in a fluid bed granulator (WSG-60, POWREX
CORPORATION), and granulated by spraying the binder liquid I (38700 g) and then dried
to give granules. A part of the obtained granules was milled in a powermill grinder
(P-7S, Showa Chemical Machinery) with 1.5 mmφ punching screen to give milled granules
A.
(2) Sodium hydroxide (405.8 g) and fumaric acid (1176 g) were dissolved in purified
water (38230 g) to give a buffer solution. Hydroxypropylcellulose (3018 g) was dissolved
in purified water (47280 g) to give binder liquid II. Compound A (20060 g), mannitol
(40860 g), crystalline cellulose (4230 g) were uniformly mixed in a fluid bed granulator
(WSG-60, POWREX CORPORATION) and granulated by spraying the buffer solution (31810
g) and then the binder liquid II (42300 g), and then dried to give granules. A part
of the obtained granules was milled in a powermill grinder (P-7S, Showa Chemical Machinery)
with 1.5 mmφ punching screen to give milled granules B. (3) Crystalline cellulose
(1620 g), crospovidone (1080 g), magnesium stearate (162 g), the milled granules A
(4536 g) and milled granules B (8802 g) were mixed in a tumbler mixer (TM-60S, Showa
Chemical Machinery) to give mixed granules.
(4) The mixed granules were tableted with a rotary tableting machine (AQUA 512SS2AI,
Kikusui Seisakusho, Ltd.) with a punch having a major axis 14 mm, a miner axis 8 mm
(tableting pressure: 9 KN, weight per tablet: 540 mg) to give plain tablets.
(5) Hydroxypropylmethylcellulose (468 g) and talc (72 g) were dissolved and dispersed
in purified water (4320 g) to give dispersion liquid I. Titanium oxide (54 g) and
iron oxide (6 g) were dispersed in purified water (900 g) to give dispersion liquid
II. The dispersion liquid I was mixed with the dispersion liquid II and purified water
(180 g) to give a coating dispersion. Using a pan coating machine (DRC-650, POWREX
CORPORATION), the coating dispersion was sprayed until the weight of the plain tablets
obtained in (4) increased by 20 mg per tablet, whereby film-coated tablets having
the following composition were obtained. Then, the film-coated tablets were dried
under the reduced pressure at 40°C for 18 hr.
[0125]
composition of preparation (per 560 mg) |
amlodipine besylate |
13.87 mg |
mannitol |
122.93 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
compound A |
85.36 mg |
mannitol |
173.86 mg |
crystalline cellulose |
18 mg |
sodium hydroxide |
1.38 mg |
fumaric acid |
4 mg |
hydroxypropylcellulose |
10.8 mg |
crystalline cellulose |
54 mg |
crospovidone |
36 mg |
magnesium stearate |
5.4 mg |
hydroxypropylmethylcellulose |
15.6 mg |
talc |
2.4 mg |
titanium oxide |
1.8 mg |
iron oxide |
0.2 mg |
total |
560 mg |
Formulation Example 9
[0126]
- (1) Hydroxypropylcellulose (162 g) was dissolved in purified water (2538 g) to give
binder liquid I. Amlodipine besylate (416.9 g), mannitol (3687 g) and crystalline
cellulose (270 g) were uniformly mixed in a fluid bed granulator (FD-5S, POWREX CORPORATION),
and granulated by spraying the binder liquid I and then dried to give granules. A
part of the obtained granules was milled in a powermill grinder (P-3, Showa Chemical
Machinery) with 1.5 mmφ punching screen to give milled granules. Crystalline cellulose
(396 g), crospovidone (198 g), magnesium stearate (39.6 g) and the milled granules
(3326 g) were mixed in a tumbler mixer (TM-60S, Showa Chemical Machinery) to give
mixed granules A.
- (2) Sodium hydroxide (62.1 g) and fumaric acid (180 g) were dissolved in purified
water (5850 g) to give a buffer solution. Hydroxypropylcellulose (486 g) was dissolved
in purified water (7614 g) to give binder liquid II. Compound A (1196 g), mannitol
(2433 g) and crystalline cellulose (252 g) were uniformly mixed in a fluid bed granulator
(FD-5S, POWREX CORPORATION), and granulated by spraying the buffer solution (1895
g) and then the binder liquid II (2520 g), and then dried to give granules. A part
of the obtained granules was milled in a powermill grinder (P-3, Showa Chemical Machinery)
with 1.5 mmφ punching screen to give milled granules. Crystalline cellulose (792 g),
crospovidone (594 g), magnesium stearate (79.2 g) and the milled granules (6455 g)
were mixed in a tumbler mixer (TM-60S, Showa Chemical Machinery) to give mixed granules
B.
- (3) The mixed granules A (180 mg) and the mixed granules B (360 mg) were tableted
in the form of a bi-layer with a rotary tableting machine (AQUA 08242L2JI, Kikusui
Seisakusho, Ltd.) with a punch having a major axis 14.8 mm, a miner axis 8 mm (tableting
pressure 11KN, weight per tablet: 540 mg) to give plain tablets.
- (4) Hydroxypropylmethylcellulose (390 g) and talc (60 g) were dissolved and dispersed
in purified water (3500 g) to give dispersion liquid I. Titanium oxide (45 g) and
iron oxide (5 g) were dispersed in purified water (750 g) to give dispersion liquid
II. The dispersion liquid I was mixed with the dispersion liquid II and purified water
(250 g) to give a coating suspension. Using a pan coating machine (DRC-500, POWREX
CORPORATION), the coating dispersion was sprayed until the weight of the plain tablets
obtained in (3) increased by 20 mg per tablet, whereby film-coated tablets having
the following composition were obtained. Then, the film-coated tablets were dried
under the reduced pressure at 40°C for 16 hr.
[0127]
composition of preparation (per 560 mg) |
amlodipine besylate |
13.87 mg |
mannitol |
122.93 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
9 mg |
magnesium stearate |
1.8 mg |
compound A |
85.36 mg |
mannitol |
173.86 mg |
crystalline cellulose |
18 mg |
sodium hydroxide |
1.38 mg |
fumaric acid |
4 mg |
hydroxypropylcellulose |
10.8 mg |
crystalline cellulose |
36 mg |
crospovidone |
27 mg |
magnesium stearate |
3.6 mg |
hydroxypropylmethylcellulose |
15.6 mg |
talc |
2.4 mg |
titanium oxide |
1.8 mg |
iron oxide |
0.2 mg |
total |
560 mg |
Reference Example 1
[0128] Compound A (42.68 g), lactose (217.32 g), crystalline cellulose (32 g) and monosodium
fumarate (10 g) were uniformly mixed in a fluid bed granulator (Lab-1, POWREX CORPORATION),
and granulated by spraying an aqueous solution of hydroxypropylcellulose (12 g) and
monosodium fumarate (10 g), and then dried in the fluid bed granulator. The obtained
granules were passed through 16 mesh sieves (aperture 1.0 mm) to give sieved granules.
Low-substituted hydroxypropylcellulose (0.8 g) and the sieved granules (16.2 g) were
mixed in a glass bottle. The obtained mixed granules were tableted with an Autograph
(manufactured by Shimadzu Corporation, AG-5000B) using a 9.5 mmφ punch (tableting
pressure: 7.5 KN/punch, weight per tablet: 398.3 mg) to give plain tablets having
the following composition. Then, the plain tablets were dried under the reduced pressure
at 40°C for 16 hr.
[0129]
composition of preparation (per 398.3 mg) |
compound A |
50 mg |
lactose |
254.6 mg |
crystalline cellulose |
37.5 mg |
hydroxypropylcellulose |
14.1 mg |
monosodium fumarate |
23.4 mg |
low-substituted hydroxypropylcellulose |
18.7 mg |
total |
398.3 mg |
Formulation Example 11
[0130]
(1) Compound A (85.36 g), amlodipine besylate (13.87 g), mannitol (184.89 g) and crystalline
cellulose (22.5 g) were uniformly mixed in a fluid bed granulator (Lab-1, POWREX CORPORATION)
and granulated by spraying an aqueous solution of hydroxypropylcellulose (12.0 g),
fumaric acid (4.0 g) and sodium hydroxide (1.38 g), and then dried in the fluid bed
granulator. The obtained granules were passed through 16 mesh sieves (aperture 1.0
mm) to give sieved granules A. Croscarmellose sodium (25.6 g), crystalline cellulose
(32.0 g), magnesium stearate (3.2 g) and the sieved granules were mixed in a polyethylene
bag.
(2) The obtained mixed granules were tableted by a rotary tableting machine (VEL50306SS2MZ,
Kikusui Seisakusho, Ltd.) using a 9.5 mmφ punch (tableting pressure: 7 KN/punch, weight
per tablet: 400 mg) to give plain tablets having the following composition. Then,
the plain tablets were dried under the reduced pressure at 40°C for 16 hr.
[0131]
composition of preparation (per 400 mg) |
compound A |
85.36 mg |
amlodipine besylate |
13.87 mg |
mannitol |
184.89 mg |
crystalline cellulose |
22.5 mg |
hydroxypropylmethylcellulose |
12 mg |
fumaric acid |
4 mg |
sodium hydroxide |
1.38 mg |
croscarmellose sodium |
40 mg |
crystalline cellulose |
32 mg |
magnesium stearate |
4 mg |
total |
400 mg |
Formulation Example 12
[0132]
(1) Amlodipine besylate (41.61 g), crystalline cellulose (35.1 g) and mannitol (349.89
g) were uniformly mixed in a fluid bed granulator (Lab-1, POWREX CORPORATION) and
granulated by spraying an aqueous solution of hydroxypropylmethylcellulose (16.2 g),
and then dried in the fluid bed granulator. The obtained granules were passed through
16 mesh sieves (aperture 1.0 mm) to give sieved granules A. Croscarmellose sodium
(15.12 g), crystalline cellulose (21.6 g), magnesium stearate (2.16 g) and the sieved
granules (177.12 g) were mixed in a polyethylene bag to give mixed granules A.
(2) Compound A (136.58 g) and mannitol (306.98 g) were uniformly mixed in a fluid
bed granulator (Lab-1, POWREX CORPORATION) and granulated by spraying an aqueous solution
of hydroxypropylcellulose (17.3 g), fumaric acid (6.4 g) and sodium hydroxide (2.21
g), and then dried in the fluid bed granulator. The obtained granules were passed
through 16 mesh sieves (aperture 1.0 mm) to give sieved granules B. Croscarmellose
sodium (32.4 g), crystalline cellulose (43.2 g), magnesium stearate (4.3 g) and the
sieved granules (352.1 g) were mixed in a polyethylene bag to give mixed granules
B.
(3) The obtained mixed granules A (180 mg) and B (360 mg) were tableted with an Autograph
(manufactured by Shimadzu Corporation, AG-5000B) using a 11 mmφ punch (tableting pressure:
9 KN/punch, weight per tablet: 540 mg) to give plain tablets having the following
composition. Then, the plain tablets were dried under the reduced pressure at 40°C
for 16 hr.
[0133]
composition of preparation (per 540 mg) |
compound A |
85.36 mg |
amlodipine besylate |
13.87 mg |
mannitol |
308.49 mg |
crystalline cellulose |
11.7 mg |
hydroxypropylcellulose |
10.8 mg |
hydroxypropylmethylcellulose |
5.4 mg |
fumaric acid |
4 mg |
sodium hydroxide |
1.38 mg |
croscarmellose sodium |
39.6 mg |
crystalline cellulose |
54 mg |
magnesium stearate |
5.4 mg |
total |
540 mg |
Comparative Example 1
[0134] Compound A (42.68 g), lactose (217.32 g), and crystalline cellulose (32 g) were uniformly
mixed in a fluid bed granulator (Lab-1, POWREX CORPORATION) and granulated by spraying
an aqueous solution of hydroxypropylcellulose (12 g) and then dried in the fluid bed
granulator. The obtained granules were passed through 16 mesh sieves (aperture 1.0
mm) to give sieved granules. Low-substituted hydroxypropylcellulose (0.8 g) and the
sieved granules (15.2 g) was mixed in a glass bottle. The obtained mixed granules
were tableted with an Autograph (manufactured by Shimadzu Corporation, AG-5000B) using
a 9.5 mmφ punch (tableting pressure: 7.5 KN/punch, weight per tablet: 374.9 mg) to
give plain tablets having the following composition. Then, the plain tablets were
dried the under reduced pressure at 40°C for 16 hr.
[0135]
composition of preparation (per 374.9 mg) |
compound A |
50 mg |
lactose |
254.6 mg |
crystalline cellulose |
37.5 mg |
hydroxypropylcellulose |
14.1 mg |
low-substituted hydroxypropylcellulose |
18.7 mg |
total |
374.9 mg |
Formulation Example 13
[0136]
- (1) Compound A (136.58 g) and mannitol (306.98 g) were uniformly mixed in a fluid
bed granulator (Lab-1, POWREX CORPORATION) and granulated by spraying an aqueous solution
of hydroxypropylcellulose (17.3 g), fumaric acid (6.4 g) and sodium hydroxide (2.21
g), and then dried in the fluid bed granulator. The obtained granules were passed
through 16 mesh sieves (aperture 1.0 mm) to give sieved granules A. Croscarmellose
sodium (32.4 g), crystalline cellulose (43.2 g), magnesium stearate (4.3 g) and the
sieved granules A (352.1 g) were mixed in a polyethylene bag to give mixed granules
A.
- (2) Crystalline cellulose (spheres) (212.5 g) was charged in a rotary granulator (SPIR-A-FLOW,
Freund Corporation), a liquid suspension of amlodipine besylate (34.675 g), crystalline
cellulose (7.825 g), low-substituted hydroxypropylcellulose (15 g) and hydroxypropylmethylcellulose
(30 g) were sprayed to spheres for layering, and the layered spheres were dried in
the rotary granulator. The obtained fine granules were passed through sieves to give
150 - 350 µm fine granules B.
- (3) Low-substituted hydroxypropylcellulose (18 g), hydroxypropylmethylcellulose (25.2
g), talc (10.8 g), titanium oxide (10.8 g) and mannitol (25.2 g) were dissolved and
dispersed in purified water (810 g) to give the liquid dispersion. The obtained fine
granules B (180 g) was coated in a rotary granulator (SPIR-A-FLOW, Freund Corporation)
until the total weight increased by 50%, and dried in the rotary granulator. The obtained
fine granules were passed through sieves to give 150 - 425 µm fine granules C.
- (4) The mixed granules A (126 g) and fine granules C (63 g) were mixed in a polyethylene
bag. The obtained mixed granules were tableted with a rotary tableting machine (VEL50306SS2MZ,
Kikusui Seisakusho, Ltd.) with a 10.5 mmφ punch (tableting pressure: 8.5 KN/punch,
tablet weight per tablet: 540 mg) to give plain tablets with the following composition.
Then, the plain tablets were dried under the reduced pressure at 40°C for 16 hr.
[0137]
composition of preparation (per 540 mg) |
compound A |
85.36 mg |
mannitol |
191.86 mg |
hydroxypropylcellulose |
10.8 mg |
fumaric acid |
4 mg |
sodium hydroxide |
1.38 mg |
amlodipine besylate |
13.87 mg |
crystalline cellulose (spheres) |
85 mg |
crystalline cellulose |
3.13 mg |
low-substituted hydroxypropylcellulose |
18 mg |
hydroxypropylmethylcellulose |
28.8 mg |
talc |
7.2 mg |
titanium oxide |
7.2 mg |
mannitol |
16.8 mg |
croscarmellose sodium |
27 mg |
crystalline cellulose |
36 mg |
magnesium stearate |
3.6 mg |
total |
540 mg |
Formulation Example 14
[0138]
(1) Hydroxypropylcellulose (2802 g) was dissolved in purified water (43900 g) to give
binder liquid I. Amlodipine besylate (5464 g), mannitol (52860 g) and crystalline
cellulose (3870 g) were uniformly mixed in a fluid bed granulator (WSG-60, POWREX
CORPORATION) and granulated by spraying the binder liquid I (38700 g) and then dried
to give granules. A part of the obtained granules was milled in a powermill grinder
(P-7S, Showa Chemical Machinery) with 1.5 mmφ punching screen to give milled granules.
Crystalline cellulose (7290 g), crospovidone (3645 g), magnesium stearate (729 g)
and the milled granules were mixed in a tumbler mixer (TM-400S, Showa Chemical Machinery)
to give mixed granules A.
(2) Sodium hydroxide (2.76 g) and fumaric acid (8 g) were dissolved in purified water
(260 g) to give a buffer solution. Hydroxypropylcellulose (16.2 g) was dissolved in
a part thereof (203.1 g) to give binder liquid II. Compound A (128 g), mannitol (260.8
g) and crystalline cellulose (27 g) were uniformly mixed in a fluid bed granulator
(Lab-1, POWREX CORPORATION) and granulated by spraying binder liquid II, and then
dried to give granules. A part of the obtained granules was passed through 16 mesh
sieves (aperture 1.0 mm) to give sieved granules. Crystalline cellulose (36 g), crospovidone
(27 g), magnesium stearate (3.6 g) and the sieved granules (293.4 g) were mixed in
a polyethylene bag to give mixed granules B.
(3) The mixed granules A (180 mg) and the mixed granules B (360 mg) were tableted
in the form of a bi-layer using Autograph (AG-500B, manufactured by Shimadzu Corporation)
with a major axis 14 mm, a miner axis 8 mmφ punch (tableting pressure 8 KN, weight
per tablet: 540 mg) to give plain tablets. Then the plain tablets were dried under
the reduced pressure at 40°C for 15 hr.
[0139]
composition of preparation (per 540 mg) |
amlodipine besylate |
13.87 mg |
mannitol |
122.93 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
9 mg |
magnesium stearate |
1.8 mg |
compound A |
85.36 mg |
mannitol |
173.86 mg |
crystalline cellulose |
18 mg |
sodium hydroxide |
1.38 mg |
fumaric acid |
4 mg |
hydroxypropylcellulose |
10.8 mg |
crystalline cellulose |
36 mg |
crospovidone |
27 mg |
magnesium stearate |
3.6 mg |
total |
540 mg |
Comparative Example 2
[0140]
(1) Hydroxypropylcellulose (2802 g) was dissolved in purified water (43900 g) to give
binder liquid I. Amlodipine besylate (5464 g), mannitol (52860 g) and crystalline
cellulose (3870 g) were uniformly mixed in a fluid bed granulator (WSG-60, POWREX
CORPORATION) and granulated by spraying the binder liquid I (38700 g) and then dried
to give granules. A part of the obtained granules was milled in a powermill grinder
(P-7S, Showa Chemical Machinery) with 1.5 mmφ punching screen to give milled granules.
Crystalline cellulose (7290 g), crospovidone (3645 g), magnesium stearate (729 g)
and the milled granules (61240 g) were mixed in a tumbler mixer (TM-400S, Showa Chemical
Machinery) to give mixed granules A.
(2) Hydroxypropylcellulose (16.2 g) was dissolved in purified water (253.8 g) to give
binder liquid II. Compound A (128 g), mannitol (268.9 g) and crystalline cellulose
(27 g) were uniformly mixed in a fluid bed granulator (Lab-1, POWREX CORPORATION)
and granulated by spraying binder liquid II, and then dried to give granules. A part
of the obtained granules was passed through 16 mesh sieves (aperture 1.0 mm) to give
sieved granules. Crystalline cellulose (36 g), crospovidone (27 g), magnesium stearate
(3.6 g) and the sieved granules (293.4 g) were mixed in a polyethylene bag to give
mixed granules B.
(3) The mixed granules A (180 mg) and the mixed granules B (360 mg) were tableted
in the form of a bi-layer using Autograph (AG-500B, manufactured by Shimadzu Corporation)
with a punch having a major axis 14 mm, a miner axis 8 mmφ (tableting pressure 8 KN,
weight per tablet: 540 mg) to give plain tablets. Then the plain tablets were dried
under the reduced pressure at 40°C for 15 hr.
[0141]
composition of preparation (per 540 mg) |
amlodipine besylate |
13.87 mg |
mannitol |
122.93 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
9 mg |
magnesium stearate |
1.8 mg |
compound A |
85.36 mg |
mannitol |
179.24 mg |
crystalline cellulose |
18 mg |
hydroxypropylcellulose |
10.8 mg |
crystalline cellulose |
36 mg |
crospovidone |
27 mg |
magnesium stearate |
3.6 mg |
total |
540 mg |
Formulation Example 15
[0142]
(1) Hydroxypropylcellulose (2802 g) was dissolved in purified water (43900 g) to give
binder liquid I. Amlodipine besylate (2982 g), mannitol (55840 g) and crystalline
cellulose (3870 g) were uniformly mixed in a fluid bed granulator (WSG-60, POWREX
CORPORATION) and granulated by spraying the binder liquid I (38700 g) and then dried
to give granules. A part of the obtained granules was milled in a powermill grinder
(P-7S, Showa Chemical Machinery) with 1.5 mmφ punching screen to give milled granules.
Crystalline cellulose (7290 g), crospovidone (3645 g), magnesium stearate (729 g)
and the milled granules (61240 g) were mixed in a tumbler mixer (TM-400S, Showa Chemical
Machinery) to give mixed granules A.
(2) Sodium hydroxide (405.8 g) and fumaric acid (1176 g) were dissolved in purified
water (38230 g) to give a buffer solution. Hydroxypropylcellulose (3018 g) was dissolved
in purified water (47280 g) to give binder liquid II. Compound A (20060 g), mannitol
(40860 g) and crystalline cellulose (4230 g) were uniformly mixed in a fluid bed granulator
(WSG-60, POWREX CORPORATION) and granulated by spraying the buffer solution (31810
g) and then the binder liquid II (42300 g), and then dried to give granules. A part
of the obtained granules was milled in a powermill grinder (P-7S, Showa Chemical Machinery)
with 1.5 mmφ punching screen to give milled granules. Crystalline cellulose (7380
g), crospovidone (5535 g), magnesium stearate (738 g) and the milled granules (60150
g) were mixed in a tumbler mixer (TM-400S, Showa Chemical Machinery) to give mixed
granules B.
(3) The mixed granules A (180 mg) and the mixed granules B (180 mg) were tableted
in the form of a bi-layer using a rotary tableting machine (HT-CVX54LS-UW/C&3L, HATA
IRON WORKS CO., LTD) with a 9.5 mmφ punch (tableting pressure 10 KN, weight per tablet:
360 mg) to give plain tablets.
(4) Hydroxypropylmethylcellulose (3978 g) and talc (612 g) were dissolved in purified
water (36720 g) to give dispersion liquid I. Titanium oxide (459 g) and iron oxide
(51 g) were dispersed in purified water (9180 g) to give dispersion liquid II. The
dispersion liquid II was added to the dispersion liquid I, and they were stirred to
give a coating dispersion. Using a pan coating machine (DRC-1200, POWREX CORPORATION),
the coating dispersion was sprayed until the weight of the plain tablets obtained
in (3) increased by 10 mg per tablet, whereby film-coated tablets having the following
composition were obtained. Then, the film-coated tablets were dried under the reduced
pressure at 40°C for 15 hr.
[0143]
composition of preparation (per 370 mg) |
amlodipine besylate |
6.935 mg |
mannitol |
129.865 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
9 mg |
magnesium stearate |
1.8 mg |
compound A |
42.68 mg |
mannitol |
86.93 mg |
crystalline cellulose |
9 mg |
sodium hydroxide |
0.69 mg |
fumaric acid |
2 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
13.5 mg |
magnesium stearate |
1.8 mg |
hydroxypropylmethylcellulose |
7.8 mg |
talc |
1.2 mg |
titanium oxide |
0.9 mg |
iron oxide |
0.1 mg |
total |
370 mg |
Formulation Example 16
[0144]
(1) Hydroxypropylcellulose (2802 g) was dissolved in purified water (43900 g) to give
binder liquid I. Amlodipine besylate (5964 g), mannitol (52860 g) and crystalline
cellulose (3870 g) were uniformly mixed in a fluid bed granulator (WSG-60, POWREX
CORPORATION) and granulated by spraying the binder liquid I (38700 g) and then dried
to give granules. A part of the obtained granules was milled in a powermill grinder
(P-7S, Showa Chemical Machinery) with 1.5 mmφ punching screen to give milled granules.
Crystalline cellulose (7290 g), crospovidone (3645 g), magnesium stearate (729 g)
and the milled granules (61240 g) were mixed in a tumbler mixer (TM-400S, Showa Chemical
Machinery) to give mixed granules A.
(2) Sodium hydroxide (405.8 g) and fumaric acid (1176 g) were dissolved in purified
water (38230 g) to give a buffer solution. Hydroxypropylcellulose (3018 g) was dissolved
in purified water (47280 g) to give binder liquid II. Compound A (20060 g), mannitol
(40860 g), crystalline cellulose (4230 g) were uniformly mixed in a fluid bed granulator
(WSG-60, POWREX CORPORATION) and granulated by spraying the buffer solution (31810
g) and then the binder liquid II (42300 g), and then dried to give granules. A part
of the obtained granules was milled in a powermill grinder (P-7S, Showa Chemical Machinery)
with 1.5 mmφ punching screen to give milled granules. Crystalline cellulose (7380
g), crospovidone (5535 g), magnesium stearate (738 g) and the milled granules (60150
g) were mixed in a tumbler mixer (TM-400S, Showa Chemical Machinery) to give mixed
granules B.
(3) The mixed granules A (180 mg) and the mixed granules B (180 mg) were tableted
in the form of a bi-layer using a rotary tableting machine (HT-CVX54LS-UW/C&3L, HATA
IRON WORKS CO., LTD) with a 9.5 mmφ punch (tableting pressure 10 KN, weight per tablet:
360 mg) to give plain tablets.
(4) Hydroxypropylmethylcellulose (3978 g) and talc (612 g) were dissolved and dispersed
in purified water (36720 g) to give dispersion liquid I. Titanium oxide (459 g) and
iron oxide (51 g) were dispersed in purified water (9180 g) to give dispersion liquid
II. The dispersion liquid II was added to the dispersion liquid I, and they were stirred
to give a coating dispersion. Using a pan coating machine (DRC-1200, POWREX CORPORATION),
the coating dispersion was sprayed until the weight of the plain tablets obtained
in (3) increased by 10 mg per tablet, whereby film-coated tablets having the following
composition were obtained. Then, the film-coated tablets were dried under the reduced
pressure at 40°C for 15 hr.
[0145]
composition of preparation (per 370 mg) |
amlodipine besylate |
13.87 mg |
mannitol |
122.93 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
9 mg |
magnesium stearate |
1.8 mg |
compound A |
42.68 mg |
mannitol |
86.93 mg |
crystalline cellulose |
9 mg |
sodium hydroxide |
0.69 mg |
fumaric acid |
2 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
13.5 mg |
magnesium stearate |
1.8 mg |
hydroxypropylmethylcellulose |
7.8 mg |
talc |
1.2 mg |
titanium oxide |
0.9 mg |
iron oxide |
0.1 mg |
total |
370 mg |
Formulation Example 17
[0146]
(1) Hydroxypropylcellulose (2802 g) is dissolved in purified water (43900 g) to give
binder liquid I. Amlodipine besylate (2982 g), mannitol (55840 g) and crystalline
cellulose (3870 g) are uniformly mixed in a fluid bed granulator (WSG-60, POWREX CORPORATION)
and granulated by spraying the binder liquid I (38700 g) and then dried to give granules.
A part of the obtained granules is milled in a powermill grinder (P-7S, Showa Chemical
Machinery) with 1.5 mmφ punching screen to give milled granules. Crystalline cellulose
(7290 g), crospovidone (3645 g), magnesium stearate (729 g) and the milled granules
(61240 g) are mixed in a tumbler mixer (TM-400S, Showa Chemical Machinery) to give
mixed granules A.
(2) Sodium hydroxide (405.8 g) and fumaric acid (1176 g) are dissolved in purified
water (38230 g) to give a buffer solution. Hydroxypropylcellulose (3018 g) is dissolved
in purified water (47280 g) to give binder liquid II. Compound A (20060 g), mannitol
(40860 g) and crystalline cellulose (4230 g) are uniformly mixed in a fluid bed granulator
(WSG-60, POWREX CORPORATION) and granulated by spraying the buffer solution (31810
g) and then the binder liquid II (42300 g), and then dried to give granules. A part
of the obtained granules is milled in a powermill grinder (P-7S, Showa Chemical Machinery)
with 1.5 mmφ punching screen to give milled granules. Crystalline cellulose (7380
g), crospovidone (5535 g), magnesium stearate (738 g) and the milled granules (60150
g) are mixed in a tumbler mixer (TM-400S, Showa Chemical Machinery) to give mixed
granules B.
(3) The mixed granules A (180 mg) and the mixed granules B (90 mg) are tableted in
the form of bi-layer using a rotary tableting machine (HT-CVX54LS-UW/C&3L, HATA IRON
WORKS CO., LTD) with a 8.5 mmφ punch (tableting pressure 9 KN, weight per tablet:
270 mg) to give plain tablets.
(4) Hydroxypropylmethylcellulose (3978 g) and talc (612 g) are dissolved and dispersed
in purified water (36720 g) to give dispersion liquid I. Titanium oxide (494.7 g)
and iron oxide (15.3 g) are dispersed in purified water (9180 g) to give dispersion
liquid II. The dispersion liquid II is added to the dispersion liquid I, and they
are mixed by stirring to give a coating dispersion. Using a pan coating machine (DRC-1200,
POWREX CORPORATION), the coating dispersion is sprayed until the weight of the plain
tablets obtained in (3) increased by 10 mg per tablet to give film-coated tablets
having the following composition. Then, the film-coated tablets are dried under the
reduced pressure at 40°C for 15 hr.
[0147]
composition of preparation (per 280 mg) |
amlodipine besylate |
6.935 mg |
mannitol |
129.865 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
9 mg |
magnesium stearate |
1.8 mg |
compound A |
21.34 mg |
mannitol |
43.465 mg |
crystalline cellulose |
4.5 mg |
sodium hydroxide |
0.345 mg |
fumaric acid |
1 mg |
hydroxypropylcellulose |
2.7 mg |
crystalline cellulose |
9 mg |
crospovidone |
6.75 mg |
magnesium stearate |
0.9 mg |
hydroxypropylmethylcellulose |
7.8 mg |
talc |
1.2 mg |
titanium oxide |
0.97 mg |
iron oxide |
0.03 mg |
total |
280 mg |
Formulation Example 18
[0148]
(1) Hydroxypropylcellulose (2802 g) is dissolved in purified water (43900 g) to give
binder liquid I. Amlodipine besylate (2982 g), mannitol (55840 g) and crystalline
cellulose (3870 g) are uniformly mixed in a fluid bed granulator (WSG-60, POWREX CORPORATION)
and granulated by spraying the binder liquid I (38700 g) and then dried to give granules.
A part of the obtained granules is milled in a powermill grinder (P-7S, Showa Chemical
Machinery) with 1.5 mmφ punching screen to give milled granules. Crystalline cellulose
(7290 g), crospovidone (3645 g), magnesium stearate (729 g) and the milled granules
(61240 g) are mixed in a tumbler mixer (TM-400S, Showa Chemical Machinery) to give
mixed granules A.
(2) Sodium hydroxide (405.8 g) and fumaric acid (1176 g) are dissolved in purified
water (38230 g) to give a buffer solution. Hydroxypropylcellulose (3018 g) is dissolved
in purified water (47280 g) to give binder liquid II. Compound A (20060 g), mannitol
(40860 g) and crystalline cellulose (4230 g) are uniformly mixed in a fluid bed granulator
(WSG-60, POWREX CORPORATION) and granulated by spraying the buffer solution (31810
g) and then the binder liquid II (42300 g), and then dried to give granules. A part
of the obtained granules is milled in a powermill grinder (P-7S, Showa Chemical Machinery)
with 1.5 mmφ punching screen to give milled granules. Crystalline cellulose (7380
g), crospovidone (5535 g), magnesium stearate (738 g) and the milled granules (60150
g) are mixed in a tumbler mixer (TM-400S, Showa Chemical Machinery) to give mixed
granules B.
(3) The mixed granules A (180 mg) and the mixed granules B (180 mg) are tableted in
the form of a bi-layer using a rotary tableting machine (HT-CVX54LS-UW/C&3L, HATA
IRON WORKS CO., LTD) with a 9.5 mmφ punch (tableting pressure 10 KN, weight per tablet:
360 mg) to give plain tablets.
(4) Hydroxypropylmethylcellulose (3978 g) and talc (612 g) are dissolved and dispersed
in purified water (36720 g) to give dispersion liquid I. Titanium oxide (494.7 g)
and iron oxide (15.3 g) are dispersed in purified water (9180 g) to give dispersion
liquid II. The dispersion liquid II is added to the dispersion liquid I, and they
are mixed by stirring to give a coating dispersion. Using a pan coating machine (DRC-1200,
POWREX CORPORATION), the coating dispersion is sprayed until the weight of the plain
tablets obtained in (3) increased by 10 mg per tablet to give film-coated tablets
having the following composition. Then, the film-coated tablets are dried under the
reduced pressure at 40°C for 15 hr.
[0149]
composition of preparation (per 370 mg) |
amlodipine besylate |
6.935 mg |
mannitol |
129.865 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
9 mg |
magnesium stearate |
1.8 mg |
compound A |
42.68 mg |
mannitol |
86.93 mg |
crystalline cellulose |
9 mg |
sodium hydroxide |
0.69 mg |
fumaric acid |
2 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
13.5 mg |
magnesium stearate |
1.8 mg |
hydroxypropylmethylcellulose |
7.8 mg |
talc |
1.2 mg |
titanium oxide |
0.97 mg |
iron oxide |
0.03 mg |
total |
370 mg |
Formulation Example 19
[0150]
(1) Hydroxypropylcellulose (2802 g) is dissolved in purified water (43900 g) to give
binder liquid I. Amlodipine besylate (2982 g), mannitol (55840 g) and crystalline
cellulose (3870 g) are uniformly mixed in a fluid bed granulator (WSG-60, POWREX CORPORATION)
and granulated by spraying the binder liquid I (38700 g) and then dried to give granules.
A part of the obtained granules is milled in a powermill grinder (P-7S, Showa Chemical
Machinery) with 1.5 mmφ punching screen to give milled granules. Crystalline cellulose
(7290 g), crospovidone (3645 g), magnesium stearate (729 g) and the milled granules
(61240 g) are mixed in a tumbler mixer (TM-400S, Showa Chemical Machinery) to give
mixed granules A.
(2) Sodium hydroxide (405.8 g) and fumaric acid (1176 g) are dissolved in purified
water (38230 g) to give a buffer solution. Hydroxypropylcellulose (3018 g) is dissolved
in purified water (47280 g) to give binder liquid II. Compound A (20060 g), mannitol
(40860 g) and crystalline cellulose (4230 g) are uniformly mixed in a fluid bed granulator
(WSG-60, POWREX CORPORATION) and granulated by spraying the buffer solution (31810
g) and then the binder liquid II (42300 g), and then dried to give granules. A part
of the obtained granules is milled in a powermill grinder (P-7S, Showa Chemical Machinery)
with 1.5 mmφ punching screen to give milled granules. Crystalline cellulose (7380
g), crospovidone (5535 g), magnesium stearate (738 g) and the milled granules are
mixed in a tumbler mixer (TM-400S, Showa Chemical Machinery) to give mixed granules
B.
(3) The mixed granules A (180 mg) and the mixed granules B (360 mg) are tableted in
the form of a bi-layer using a rotary tableting machine (HT-CVX54LS-UW/C&3L, HATA
IRON WORKS CO., LTD) with a punch having a major axis 14 mm, a miner axis 8 mm (tableting
pressure 11 KN, weight per tablet: 540 mg) to give plain tablets.
(4) Hydroxypropylmethylcellulose (3978 g) and talc (612 g) are dissolved and dispersed
in purified water (36720 g) to give dispersion liquid I. Titanium oxide (494.7 g),
iron oxide (15.3 g) are dispersed in purified water (9180 g) to give dispersion liquid
II. The dispersion liquid II is added to the dispersion liquid I, and they are mixed
by stirring to give a coating dispersion. Using a pan coating machine (DRC-1200, POWREX
CORPORATION), the coating dispersion is sprayed until the weight of the plain tablets
obtained in (3) increased by 20 mg per tablet to give film-coated tablets having the
following composition. Then, the film-coated tablets are dried under the reduced pressure
at 40°C for 15 hr.
[0151]
composition of preparation (per 560 mg) |
amlodipine besylate |
6.935 mg |
mannitol |
129.865 mg |
crystalline cellulose |
9 mg |
hydroxypropylcellulose |
5.4 mg |
crystalline cellulose |
18 mg |
crospovidone |
9 mg |
magnesium stearate |
1.8 mg |
compound A |
85.36 mg |
mannitol |
173.86 mg |
crystalline cellulose |
18 mg |
sodium hydroxide |
1.38 mg |
fumaric acid |
4 mg |
hydroxypropylcellulose |
10.8 mg |
crystalline cellulose |
36 mg |
crospovidone |
27 mg |
magnesium stearate |
3.6 mg |
hydroxypropylmethylcellulose |
15.6 mg |
talc |
2.4 mg |
titanium oxide |
1.94 mg |
iron oxide |
0.06 mg |
total |
560 mg |
Experimental Example 1
[0152] The drug dissolution property of the dried plain tablets (free form of compound A)
obtained in Reference Example 1 and Comparative Example 1 was evaluated by a dissolution
test (0.5 w/w% sodium dodecyl sulfate-comprising phosphate buffer (pH 6.8), 900 mL,
Paddle Method, 50 rpm, 37°C). The dissolution test was performed according to the
Japanese Pharmacopoeia 14th Edition Dissolution Test Method 2 (Paddle Method). The results are shown in Fig. 1, wherein
-●- shows the results (dissolution ratio (%) of free form of compound A contained
in the dry plain tablet of Reference Example 1) of the dried plain tablet of Reference
Example 1 and -○- shows the results (dissolution ratio (%) of free form of compound
A contained in the dry plain tablet of Comparative Example 1) of the dried plain tablet
of Comparative Example 1.
As shown in Fig. 1, it was demonstrated that addition of a pH control agent improves
dissolution property.
Experimental Example 2
[0153] The dried plain tablets obtained in Reference Example 1 and Comparative Example 1
were stored in a closed glass bottle with a desiccant at 40°C for one month. An increase
in the amount of decomposed products was measured by the following method.
Compound A was dissolved in an extract at about 1 µg/mL, and the solution was filtered
using a non-aqueous filter (0.45 µm) and quantified by high performance liquid column
chromatography (HPLC) under the following conditions.
[0154] HPLC conditions
detector: ultraviolet absorption photometer,
measurement wavelength: 240 nm
column: YMC-Pack Pro C18, 5 µm, inner diameter: 4.6 mm, length: 150 mm
column temperature: 25°C
mobile phase(A): 0.05 mol/L phosphate buffer (pH 3.0)/acetonitrile mixed solution
(9:1)
mobile phase(B): 0.05 mol/L phosphate buffer (pH 3.0)/acetonitrile mixed solution
(3:7)
flow: 1 mL/min
gradient program (linear)
[0155]
time (min) |
mobile phase (A) (%) |
mobile phase (B) (%) |
0 (injecting) |
100 |
0 |
10 |
70 |
30 |
90 |
0 |
100 |
91 |
100 |
0 |
110 (injecting) |
100 |
0 |
[0156] The results are shown in Table 1. As shown in Table 1, it was demonstrated that addition
of a pH control agent suppresses the decomposition of compound A.
[0157]
Table 1
preparation |
increase (%) in the amount of decomposed products |
tablet of Formulation Example 10 |
1.31 |
tablet of Comparative Example 1 |
3.83 |
Experimental Example 3
[0158] The dried plain tablets obtained in Formulation Example 11 and Formulation Example
12 were stored in a closed glass bottle with a desiccant at 60°C for 2 weeks. An increase
in the amount of decomposed products was measured in the following manner.
Compound A was dissolved in an extract to about 1 µm/mL, filtered through a non-aqueous
filter (0.45 µm) and subjected to measurement by high performance liquid column chromatography
(HPLC) under the following conditions.
[0159] HPLC conditions
detector: ultraviolet absorption photometer,
measurement wavelength: 237 nm
column: YMC-Pack Pro C18, 5 µm, inner diameter: 4.6 mm, length: 150 mm
column temperature: 25°C
mobile phase (A): 0.05 mol/L phosphate buffer (pH 3.0) mobile phase (B): acetonitrile
flow: 1 mL/min
gradient program (linear)
[0160]
time (min) |
mobile phase (A)(%) |
mobile phase (B)(%) |
0 (injecting) |
80 |
20 |
40 |
60 |
40 |
70 |
30 |
70 |
80 |
30 |
70 |
81 |
80 |
20 |
90 (injecting) |
80 |
20 |
[0161] The results are shown in Table 2. As shown in Table 2, it was demonstrated that
granulation of each compound suppresses the decomposition of compound A.
[0162]
Table 2
preparation |
increase (%) in the amount of decomposed products |
tablet of Formulation Example 11 |
5.45 |
tablet of Formulation Example 12 |
2.78 |
Experimental Example 4
[0163] The drug dissolution property of the dried plain tablets (free form of compound A)
obtained in Formulation Example 14 and Comparative Example 2 was evaluated according
to a method similar to that in Experimental Example 1. The results are shown in Fig.
2, wherein -●- shows the results (dissolution ratio (%) of free form of compound A
contained in the dry plain tablet of Comparative Example 14) of the dried plain tablet
of Example 14 and -O- shows the results (dissolution ratio (%) of free form of compound
A contained in the dry plain tablet of Comparative Example 2) of the dried plain tablet
of Comparative Example 2.
As shown in Fig. 2, it was demonstrated that addition of a pH control agent improves
dissolution property.
Experimental Example 5
[0164] The dried plain tablets obtained in Formulation Example 14 and Comparative Example
2 were stored in a closed glass bottle with a desiccant at 60°C for 2 weeks. An increase
in the amount of decomposed products was measured in the following manner.
Compound A was dissolved in an extract to about 1.6 mg/mL, filtered through a non-aqueous
filter (0.45 µm) and subjected to measurement by high performance liquid column chromatography
(HPLC) under the following conditions.
[0165] HPLC conditions
detector: ultraviolet absorption photometer,
measurement wavelength: 240 nm
column: YMC-Pack Pro C18, 5 µm, inner diameter: 4.6 mm,
length: 250 mm
column temperature: 25°C
mobile phase (A): 0.05 mol/L phosphate buffer (pH 3.0)/acetonitrile mixed solution
(4:1)
mobile phase (B): 0.05 mol/L phosphate buffer (pH 3.0)/acetonitrile mixed solution
(3:7)
flow: 1 mL/min
gradient program (linear)
[0166]
time (min) |
mobile phase (A) (%) |
mobile phase (B) (%) |
0 (injecting) |
85 |
15 |
20 |
85 |
15 |
90 |
0 |
100 |
91 |
85 |
15 |
100 (injecting) |
85 |
15 |
[0167] The results are shown in Table 3. As shown in Table 3, it was demonstrated that addition
of a pH control agent suppresses the decomposition of compound A.
[0168]
Table 3
preparation |
increase (%) in the amount of decomposed products |
tablet of Formulation Example 14 |
2.15 |
tablet of Comparative Example 2 |
2.55 |
INDUSTRIAL APPLICABILITY
[0169] The present invention is advantageous in that a solid preparation superior in the
dissolution property, stability and the like of compound (I) can be provided. In addition,
the present invention advantageously provides a solid preparation containing a combination
of compound (I) and a calcium antagonist, which is superior in the stability of compound
(I) and a calcium antagonist.
[0170] While some of the embodiments of the present invention have been described in detail
in the above, those of ordinary skill in the art can enter various modifications and
changes to the particular embodiments shown without substantially departing from the
novel teaching and advantages of the present invention. Such modifications and changes
are encompassed in the spirit and scope of the present invention as set forth in the
appended claims.