Mannose derivatives as antagonists of bacterial adhesion

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EP 2 604 619 A3

(12)	EUROPEAN PATENT APPLICATION

(88)	Date of publication A3:
	22.01.2014 Bulletin 2014/04

(43)	Date of publication A2:
	19.06.2013 Bulletin 2013/25

(21)	Application number: 13158420.3

(22)	Date of filing: 13.12.2010

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International Patent Classification (IPC):

C07H 15/18^(2006.01)
C07H 15/26^(2006.01)
A61P 31/04^(2006.01)

C07H 15/203^(2006.01)
A61K 31/7034^(2006.01)

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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Priority:

14.12.2009 EP 09179007

(62)	Application number of the earlier application in accordance with Art. 76 EPC:
	10798030.2 / 2513128

(71)	Applicant: University of Basel
	4003 Basel (CH)

(72)	Inventors:
	Ernst, Beat 4312 Magden (CH) Herold, Janno 4052 Basel (CH)

(74)	Representative: Becker, Konrad
	Aeschenvorstadt 24 Postfach 318 4010 Basel 4010 Basel (CH)

(54)	Mannose derivatives as antagonists of bacterial adhesion

(57) Compounds of the formula (I)

wherein n is 0, 1 or 2, R¹ is aryl, heteroaryl or heterocyclyl, and R² and R³ are hydrogen or a substituent as described in the specification, are useful for the prevention and treatment of bacterial infections, in particular of urinary infections caused by E. coli.

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