IDENTIFICATION OF COMMON TUMOR-SPECIFIC T CELL RECEPTORS AND ANTIGENS

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(11)

EP 4 249 592 A3

(12)	EUROPEAN PATENT APPLICATION

(88)	Date of publication A3:
	20.03.2024 Bulletin 2024/12

(43)	Date of publication A2:
	27.09.2023 Bulletin 2023/39

(21)	Application number: 23176208.9

(22)	Date of filing: 15.07.2022

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International Patent Classification (IPC):

A61K 35/17^(2015.01)
C07K 16/28^(2006.01)
C12Q 1/6809^(2018.01)
A61K 39/00^(2006.01)
C12N 5/10^(2006.01)
G01N 33/50^(2006.01)

A61P 35/00^(2006.01)
C12N 15/10^(2006.01)
G01N 33/574^(2006.01)
C12N 5/0783^(2010.01)
C07K 14/725^(2006.01)

(52)	Cooperative Patent Classification (CPC):
	C12N 15/1075; A61K 35/17; A61P 35/00; C12Q 1/6809; A61K 39/0011; C12N 5/0636; G01N 33/505; G01N 2800/7028; C12N 2510/00; C07K 14/7051; A61K 39/4611; A61K 39/4632

	C-Sets:
	C12N 15/1075, C12Q 2535/122, C12Q 2537/165, C12Q 2563/131; C12Q 1/6809, C12Q 2535/122, C12Q 2537/165, C12Q 2563/131;

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
	Designated Extension States:
	BA ME
	Designated Validation States:
	KH MA MD TN

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Priority:

15.07.2021 EP 21185876

(62)	Application number of the earlier application in accordance with Art. 76 EPC:
	22777948.5 / 4225333

(71)	Applicant: Boehringer Ingelheim International GmbH
	55216 Ingelheim am Rhein (DE)

(72)	Inventor:
	Hennig, Steffen 10961 Berlin (DE)

(74)	Representative: Schulz Junghans Patentanwälte PartGmbB
	Großbeerenstraße 71 10963 Berlin 10963 Berlin (DE)

(54)	IDENTIFICATION OF COMMON TUMOR-SPECIFIC T CELL RECEPTORS AND ANTIGENS

(57) The present invention relates to a method for identification of common patient-spanning tumor-specific T cell receptors (TCRs) and their corresponding antigens. The invention also relates to these TCR sequences, a nucleic acid encoding the TCR, and a T cell comprising the TCR and/or the encoding nucleic acid.

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