EP 0065531 A1 19821201 - NEW GALENIC PREPARATION OF PHENOFIBRATE, METHOD FOR THE OBTENTION THEREOF, ITS APPLICATION AS A MEDICINE.
Title (en)
NEW GALENIC PREPARATION OF PHENOFIBRATE, METHOD FOR THE OBTENTION THEREOF, ITS APPLICATION AS A MEDICINE.
Title (de)
NEUE GALENISCHE VERABREICHUNGSFORM DES FENOFIBRATS, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN ANWENDUNG ALS ARZNEIMITTEL.
Title (fr)
NOUVELLE FORME GALENIQUE DU FENOFIBRATE, SON PROCEDE D'OBTENTION, SON APPLICATION COMME MEDICAMENT.
Publication
Application
Priority
FR 8024568 A 19801119
Abstract (en)
[origin: WO8201649A1] The medicine is formed with granules, each of them being comprised of a neutral core (saccharose + starch) covered with a first layer of phenofibrate admixed with an excipient, and with a second microporous outer layer of an edible polymer. The daily administration of one capsule of 250 mg instead of three doses of 100 mg allows to reduce the dosing and the number of administrations due to the progressive and retarded release of the phenofibrate. A minimum dose is maintained in the blood, high temporary concentrations are avoided and the total ingested quantity is reduced.
Abstract (fr)
Le medicament est forme de granules constituees chacune d'un noyau neutre (saccharose + amidon) recouvert d'une premiere couche de fenofibrate en melange avec un excipient, et d'une deuxieme couche exterieure microporeuse d'un polymere comestible. L'administration d'une gelule de 250 mg par jour au lieu de trois prises de 100 mg permet ainsi de reduire le dosage et le nombre d'administrations grace a la liberation progressive et retardee du fenofibrate. On maintient une dose minimale dans le sang, on evite les fortes concentrations temporaires, et on reduit la quantite totale ingeree.
IPC 1-7
IPC 8 full level
A61K 9/16 (2006.01); A61K 9/50 (2006.01); A61K 9/52 (2006.01); A61K 31/19 (2006.01); A61K 31/215 (2006.01); A61K 31/22 (2006.01); A61K 31/395 (2006.01)
CPC (source: EP)
A61K 9/5078 (2013.01); A61K 31/22 (2013.01)
Designated contracting state (EPC)
FR
DOCDB simple family (publication)
WO 8201649 A1 19820527; AT 387517 B 19890210; AT A906481 A 19880715; BE 891129 A 19820517; DE 3152519 C2 19901122; DE 3152519 T1 19831229; EP 0065531 A1 19821201; FR 2494112 A1 19820521; FR 2494112 B1 19860110; IT 1144948 B 19861029; IT 8125185 A0 19811119; NL 8120434 A 19821001
DOCDB simple family (application)
FR 8100148 W 19811118; AT 906481 A 19811118; BE 1010357 A 19811116; DE 3152519 T 19811118; EP 81903096 A 19811118; FR 8024568 A 19801119; IT 2518581 A 19811119; NL 8120434 A 19811118