EP 0710250 A1 19960508 - HUMAN MHC CLASS II DOUBLE TRANSGENE AND USES
Title (en)
HUMAN MHC CLASS II DOUBLE TRANSGENE AND USES
Title (de)
TRANSGENE; DIE MENSCHLICHE MHG DER KLASSE II ENTHALTEN UND DEREN ANWENDUNGEN
Title (fr)
DOUBLE TRANSGENE DE LA CLASSE II DU COMPLEXE MAJEUR D'HISTOCOMPATIBILITE HUMAIN ET SES UTILISATIONS
Publication
Application
Priority
- GB 9401582 W 19940722
- GB 9315303 A 19930723
Abstract (en)
[origin: GB2280186A] There is disclosed a human MHC Class II HLA alpha, beta-DR double transgene, preferably selected from the DR1, DR4 and DR10 sub-types, together with a human beta HLA-DR4Dw4 transgene, which may be used in the transfection of non-human animals. The polypeptide, expressed by the double transgene, may be used in the identification of agents which modulate the production or release of an immunologically-active mediator, involving formation of a complex of polypeptide, putative agent and a factor, which complex interacts with T cells, thereby releasing the mediator. The chromasomal integration site of a transgene, especially alpha HLA-DR4Dw4, may be determined, in a non-human mammal, by in situ fluorescence hybridisation.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); C07K 14/74 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12N 15/85 (2006.01); C12Q 1/68 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01)
CPC (source: EP)
A01K 67/0278 (2013.01); C07K 14/70539 (2013.01); C12N 15/8509 (2013.01); A01K 2207/15 (2013.01); A01K 2217/00 (2013.01); A01K 2217/05 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0381 (2013.01)
Citation (search report)
See references of WO 9503331A1
Designated contracting state (EPC)
CH DE FR GB IT LI
DOCDB simple family (publication)
GB 2280186 A 19950125; GB 9414833 D0 19940914; AU 7231494 A 19950220; EP 0710250 A1 19960508; GB 9315303 D0 19930908; JP H09501315 A 19970210; WO 9503331 A1 19950202
DOCDB simple family (application)
GB 9414833 A 19940722; AU 7231494 A 19940722; EP 94921706 A 19940722; GB 9315303 A 19930723; GB 9401582 W 19940722; JP 50501794 A 19940722