EP 0738274 A1 19961023 - NOVEL NUCLEOSIDE-LIPID ADDITION COMPOUNDS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL USE
Title (en)
NOVEL NUCLEOSIDE-LIPID ADDITION COMPOUNDS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL USE
Title (de)
NEUE NUKLEOSID-LIPID-ADDUKTE, IHRE HERSTELLUNG UND IHRE PHARMAZEUTISCHE VERWENDUNG
Title (fr)
NOUVEAUX PRODUITS D'ADDITION NUCLEOSIDE-LIPIDE, PREPARATION ET UTILISATION PHARMACEUTIQUE
Publication
Application
Priority
- DE 9500041 W 19950104
- DE 4400310 A 19940107
Abstract (en)
[origin: WO9518816A1] The invention relates to novel nucleoside-lipid addition compounds of general formula (I) including all enantiomeric forms and all pharmaceutically usable salts of said compounds. The field of use is in the chemical and pharmaceutical industry. The compounds (I) with a diphosphate or phosphono-phosphate grouping are produced by condensing nucleoside-5'-phosphonophosphoamidates with the corresponding lipid phosphates or phosphonates or by condensing the lipid phosphoamidates or lipid phosphonoamidates with the corresponding 5'-nucleoside monophosphates. The compounds (I) containing a triphosphate or a phosphonodiphosphate group are obtained by condensing a nucleoside diphosphoamidate with an alkyl phosphate or alkyl phosphonate or by reacting a lipid phosphoamidate or lipid phosphonoamidate with a 5'-nucleoside phosphate or by condensing a lipid diphosphate or a lipid phosphonophosphate with a 5'-nucleoside monophosphoamidate or by reacting a lipid phosphoamidate or a lipid phosphonophosphoamidate with a 5'-nucleoside monophosphate. The compounds of formula (I) have a cytostatic effect.
IPC 1-7
IPC 8 full level
C07H 19/10 (2006.01); C07H 19/20 (2006.01)
CPC (source: EP)
C07H 19/10 (2013.01); C07H 19/20 (2013.01)
Citation (search report)
See references of WO 9518816A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
DE 4400310 A1 19950713; EP 0738274 A1 19961023; WO 9518816 A1 19950713
DOCDB simple family (application)
DE 4400310 A 19940107; DE 9500041 W 19950104; EP 95905541 A 19950104