Global Patent Index - EP 0763103 A4

EP 0763103 A4 19980715 - GENE DELIVERY VECTOR USING PLASMID DNA PACKAGED INTO AN ADENOVIRUS AND A PACKAGING CELL LINE

Title (en)

GENE DELIVERY VECTOR USING PLASMID DNA PACKAGED INTO AN ADENOVIRUS AND A PACKAGING CELL LINE

Title (de)

GENVERABREICHENDER VEKTOR AUS IN ADENVIRUS VERPACKTER PLASMID-DNA UND EINE VERPACKUNGSZELLINIE

Title (fr)

VECTEUR D'APPORT DE GENES UTILISANT UN ADN PLASMIDIQUE ENCAPSULE DANS UN ADENOVIRUS ET UNE LIGNEE CELLULAIRE D'ENCAPSIDATION

Publication

EP 0763103 A4 19980715 (EN)

Application

EP 95917176 A 19950425

Priority

  • US 9505174 W 19950425
  • US 23499094 A 19940428

Abstract (en)

[origin: WO9529993A1] This invention provides a novel expression vector useful for inserting and expressing foreign nucleic acid molecules in a host cell. The expression vector of this invention is derived from an adenovirus and has as its components the adenoviral Inverted Terminal Repeat, an adenoviral packaging sequence, and the DNA molecule to be inserted. This invention also provides a pseudo-adenoviral expression vector having a foreign or heterologous DNA molecule inserted within adenoviral capsid proteins. These vectors are useful for gene therapy.

IPC 1-7

C12N 5/10; C12N 15/86

IPC 8 full level

A01K 67/027 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 15/09 (2006.01); C12N 15/861 (2006.01)

CPC (source: EP)

C12N 15/86 (2013.01); C12N 2710/10343 (2013.01)

Citation (search report)

  • [PX] WO 9428152 A1 19941208 - TRANSGENE SA [FR], et al
  • [X] STRATFORD-PERRICAUDET AND PERRICAUDET: "Gene transfer into animals: the promise of adenovirus", HUMAN GENE TRANSFER (COHEN-HAGUENAUER AND BOIRON EDS.), vol. 219, 1991, pages 51 - 61, XP002064227
  • [X] ROSENFELD ET AL.: "In vivo transfer of the human Cystic Fibrosis Transmembrane Conductance Regulator gene to the airway epithelium", CELL, vol. 68, no. 1, 10 January 1992 (1992-01-10), NA US, pages 143 - 155, XP002064228
  • [XD] MASTRANGELI ET AL.: "Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 91, January 1993 (1993-01-01), pages 225 - 234, XP000616634
  • [A] GRABLE AND HEARING: "cis and trans Requirements for the selective packaging of Adenovirus type 5 DNA", JOURNAL OF VIROLOGY, vol. 66, no. 2, February 1992 (1992-02-01), AMERICAN SOCIETY FOR MICROBIOLOGY US, pages 723 - 731, XP002012398
  • See references of WO 9529993A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9529993 A1 19951109; CA 2189067 A1 19951109; EP 0763103 A1 19970319; EP 0763103 A4 19980715; JP H10507061 A 19980714

DOCDB simple family (application)

US 9505174 W 19950425; CA 2189067 A 19950425; EP 95917176 A 19950425; JP 52836395 A 19950425