EP 0846253 A4 20091111 - BIOLOGICAL FLUID ANALYSIS USING DISTANCE OUTLIER DETECTION
Title (en)
BIOLOGICAL FLUID ANALYSIS USING DISTANCE OUTLIER DETECTION
Title (de)
ANALYSE EINER BIOLOGISCHEN FLÜSSIGKEIT DURCH ERFASSUNG ABWEICHENDER WERTE MIT GENERALISIERTEN ENTFERNUNGEN
Title (fr)
ANALYSE DE FLUIDES BIOLOGIQUES PAR DETECTION DES VALEURS ABERRANTES PAR DISTANCES GENERALISEES
Publication
Application
Priority
- US 9612625 W 19960802
- US 195095 P 19950807
- US 58701796 A 19960116
Abstract (en)
[origin: WO9706418A1] A method and apparatus for measuring the concentration of an analyte present in a biological fluid is disclosed. The method includes the steps of applying NIR radiation to calibration samples to produce calibration data, analyzing calibration data to identify and remove outliers, constructing a calibration model, collecting and analyzing unknown samples to identify and remove outliers, and predicting analyte concentration of non-outliers from the calibration model. Analysis of calibration data includes data pretreatment, data decomposition to remove redundant data, and identification and removal of outliers using generalized distances. The apparatus (100) includes a pump (102) which circulates a sample through tubing (104) to fill a flowcell (106). Light from a NIR source (114) is synchronized with a detector (110), facilitating light and dark measurements, and passes through a monochrometer (120) and the flowcell (106) and strikes the detector (110), whereby radiation transmitted through the sample is measured.
IPC 1-7
IPC 8 full level
G01N 33/483 (2006.01); G01N 21/27 (2006.01); G01N 21/35 (2006.01); G01N 33/50 (2006.01); G01N 33/66 (2006.01); G01N 33/68 (2006.01); G01N 33/92 (2006.01); G01N 37/00 (2006.01); G01J 3/28 (2006.01)
CPC (source: EP)
G01N 21/274 (2013.01); G01N 21/359 (2013.01); G01J 2003/2866 (2013.01)
Citation (search report)
- [A] US 4975581 A 19901204 - ROBINSON MARK R [US], et al
- [X] HAALAND D M ET AL: "REAGENTLESS NEAR-INFRARED DETERMINATION OF GLUCOSE IN WHOLE BLOOD USING MULTIVARIATE CALIBRATION*", APPLIED SPECTROSCOPY, THE SOCIETY FOR APPLIED SPECTROSCOPY. BALTIMORE, US, vol. 46, no. 10, 1 October 1992 (1992-10-01), pages 1575 - 1578, XP000307972, ISSN: 0003-7028
- [A] ATKINSON A C ET AL: "THE STALACTITE PLOT FOR THE DETECTION OF MULTIVARIATE OUTLIERS", STATISTICS AND COMPUTING, LONDON, GB, vol. 3, no. 1, 1 March 1993 (1993-03-01), pages 27 - 35, XP008041399, ISSN: 0960-3174
- [A] DALLAL G E ET AL: "LMSMVE: A program for least median of squares regression and robust distances", 1 August 1992, COMPUTERS AND BIOMEDICAL RESEARCH, ACADEMIC PRESS, LONDON, GB, PAGE(S) 384 - 391, ISSN: 0010-4809, XP022956305
- [T] DE MAESSCHALCK R ET AL: "The Mahalanobis distance", CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 50, no. 1, 1 January 2000 (2000-01-01), pages 1 - 18, XP004184173, ISSN: 0169-7439
- See references of WO 9706418A1
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
WO 9706418 A1 19970220; AU 6644896 A 19970305; AU 711324 B2 19991014; CA 2228844 A1 19970220; CA 2228844 C 20060314; EP 0846253 A1 19980610; EP 0846253 A4 20091111; JP 3323512 B2 20020909; JP H11510604 A 19990914; MX 9801056 A 19980531
DOCDB simple family (application)
US 9612625 W 19960802; AU 6644896 A 19960802; CA 2228844 A 19960802; EP 96926226 A 19960802; JP 50854897 A 19960802; MX 9801056 A 19960802