Global Patent Index - EP 0902836 A4

EP 0902836 A4 20041222 - ASYMMETRIC HAMMERHEAD RIBOZYMES

Title (en)

ASYMMETRIC HAMMERHEAD RIBOZYMES

Title (de)

ASYMMETRISCHE HAMMERHEAD-RIBOZYME

Title (fr)

RIBOZYMES ASYMETRIQUES EN FORME DE TETE DE MARTEAU

Publication

EP 0902836 A4 20041222 (EN)

Application

EP 97913997 A 19970402

Priority

  • AU 9700210 W 19970402
  • US 62703396 A 19960402
  • US 1465996 P 19960402

Abstract (en)

[origin: WO9737013A1] This invention is directed to a compound having the formula (I), wherein N may be a nucleotide, n is from 1-5 and n' is from 1-3. Such asymmetric ribozymes have higher than normal cleavage rates. The compound may be covalently linked to a delivery agent. The invention also includes a composition which comprises the compound in association with an acceptable carrier. The invention also includes a method of cleaving an RNA target sequence with the compound as described above. Further, a method of treating a disease in man or animals associated with a particular RNA which comprises administrating to the man or animal the compound. Further, the invention also includes a diagnostic reagent which comprises the compound.

IPC 1-7

C12N 15/11; A61K 31/70

IPC 8 full level

C12N 15/09 (2006.01); A61K 31/70 (2006.01); A61K 31/7088 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01)

CPC (source: EP)

C12N 15/113 (2013.01); A61K 38/00 (2013.01); C12N 2310/121 (2013.01); C12N 2310/321 (2013.01); C12N 2310/351 (2013.01)

Citation (search report)

  • [Y] WO 9119789 A1 19911226 - COMMW SCIENT IND RES ORG [AU]
  • [XY] DENMAN ROBERT B ET AL: "Differential activity of trans-acting hammerhead ribozymes targeted to beta amyloid peptide precursor mRNA by altering the symmetry of helices I and III", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 323, no. 1, 1995, pages 71 - 78, XP002303023, ISSN: 0003-9861
  • [DA] TABLER M ET AL: "A THREE-NUCLEOTIDE HELIX I IS SUFFICIENT FOR FULL ACTIVITY OF A HAMMERHEAD ROBOZYME: ADVANTAGES OF AN ASYMMETRIC DESIGN", NUCLEIC ACIDS RESEARCH, vol. 22, no. 19, 1994, pages 3958 - 3965, XP002051226, ISSN: 0305-1048
  • [DA] AMIRI KHALED M A ET AL: "Global conformation of a self-cleaving hammerhead RNA", BIOCHEMISTRY, vol. 33, no. 45, 1994, pages 13172 - 13177, XP002303024, ISSN: 0006-2960
  • [DA] ZOUMADAKIS M ET AL: "Comparative analysis of cleavage rates after systematic permutation of the NUX consensus target motif for hammerhead ribozymes.", NUCLEIC ACIDS RESEARCH, vol. 23, no. 7, 11 April 1995 (1995-04-11), pages 1192 - 1196, XP002303025, ISSN: 0305-1048
  • [DA] HENDRY PHILIP ET AL: "A comparison of the in vitro activity of DNA-armed and all-RNA hammerhead ribozymes", NUCLEIC ACIDS RESEARCH, vol. 23, no. 19, 1995, pages 3928 - 3936, XP002303026, ISSN: 0305-1048
  • [PX] HENDRY PHILIP ET AL: "Unexpected anisotropy in substrate cleavage rates by asymmetric hammerhead ribozymes", NUCLEIC ACIDS RESEARCH, vol. 24, no. 14, 15 July 1996 (1996-07-15), pages 2679 - 2684, XP002303027, ISSN: 0305-1048
  • See references of WO 9737013A1

Designated contracting state (EPC)

DE FR GB IT

DOCDB simple family (publication)

WO 9737013 A1 19971009; AU 2145097 A 19971022; AU 721758 B2 20000713; CA 2250857 A1 19971009; EP 0902836 A1 19990324; EP 0902836 A4 20041222; JP 2000509969 A 20000808

DOCDB simple family (application)

AU 9700210 W 19970402; AU 2145097 A 19970402; CA 2250857 A 19970402; EP 97913997 A 19970402; JP 53475197 A 19970402