Global Patent Index - EP 0948597 A4

EP 0948597 A4 20020710 - HUMAN MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1 (MAdCAM-1) AND SPLICE VARIANTS THEREOF

Title (en)

HUMAN MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1 (MAdCAM-1) AND SPLICE VARIANTS THEREOF

Title (de)

Menschliches, Schleimhaut-spezifisches Addressin-Zelladhäsionsmolekül (MAdCAM-1) und dessen Spleissvarianten

Title (fr)

MOLECULE 1 D'ADHERENCE CELLULAIRE D'ADRESSINE DE MUQUEUSE HUMAINE (MAdCAM-1) ET VARIANTS D'EPISSURE DE CETTE DERNIERE

Publication

EP 0948597 A4 20020710 (EN)

Application

EP 96938720 A 19961101

Priority

US 9617549 W 19961101

Abstract (en)

[origin: WO9820110A1] The present invention relates to novel MAdCAM-1 proteins designated herein as MAdCAM-1(a-e), which are cell adhesion molecules. In particular, isolated nucleic acid molecules are provided encoding the human MAdCAM-1(a-e) proteins. MAdCAM-1(a-e) polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of MAdCAM-1(a-e) activity. Also provided are diagnostic methods for detecting cancer or a pathological inflammatory condition, and therapeutic methods for treating an individual in need of a reduction in the activity of any of MAdCAM-1(a-e). In another aspect, the invention provides isolated genomic DNA molecules comprising the 5 exons which comprise the genes which encode any of MAdCAM-1(a-e), as well as the 5' flanking region which includes the promoter for these genes. In another aspect, the invention relates to a method of screening compounds for the ability to regulate expression of any of MAdCAM-1(a-e) from their promoter. The invention also relates to a method of selectively expressing genes on gut endothelia.

IPC 1-7

C12N 1/21; C12N 5/10; C12N 15/12; C12N 15/64; C12N 15/66; C12N 15/70; C12N 15/79; C07K 14/705

IPC 8 full level

A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); C12R 1/19 (2006.01)

CPC (source: EP)

A61P 29/00 (2017.12); A61P 43/00 (2017.12); C07K 14/70503 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9820110 A1 19980514; EP 0948597 A1 19991013; EP 0948597 A4 20020710; JP 2001503271 A 20010313

DOCDB simple family (application)

US 9617549 W 19961101; EP 96938720 A 19961101; JP 52132098 A 19961101