Global Patent Index - EP 0991626 A2

EP 0991626 A2 2000-04-12 - PYRIMIDIN-2,4,6-TRION DERIVATIVES, METHOD FOR PRODUCING THE SAME AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

Title (en)

PYRIMIDIN-2,4,6-TRION DERIVATIVES, METHOD FOR PRODUCING THE SAME AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

Title (de)

PYRIMIDIN-2,4,6-TRION-DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL

Title (fr)

DERIVES DE PYRIMIDINE-2,4,6-TRIONE, LEUR PROCEDE DE PRODUCTION ET MEDICAMENTS CONTENANT CES COMPOSES

Publication

EP 0991626 A2 (DE)

Application

EP 98937509 A

Priority

  • DE 19726427 A
  • EP 9803740 W

Abstract (en)

[origin: DE19726427A1] The invention relates to substances of general formula (I), where R1 and R2, independently of each other, can be H, alkenyl or alkyl, R3 is a W-V group, where W is a bond or a linear or branched alkyl group, which is optionally interrupted by oxygen, sulphur or nitrogen and can be substituted with hydroxy-, amino-, mercapto-, alkoxy-, oxo-, carboxy-, acyl-, alkyl-, aralkyl-, aryl- or heteroaryl groups, and in which V is H, a monocyclic or bicyclic, saturated or unsaturated ring, which can possibly contain between 1 and 4 nitrogen, oxygen or sulphur atoms and can be optionally substituted with hydroxy-, amino-, mercapto-, alkoxy-, oxo-, carboxy-, acyl-, acylamido-, alkyl-, aralkyl-, aryl- or heteroaryl groups; R4 is an -N(R13)-C(O)-R5, -N(R13)-C(O)-OR5, -N(R13)-SO2-R5, -N(R13)-C(S)-R5, -N(R13)-C(S)-OR5, -N(R13)-C(O)-CR14R15(-CR16R17)n -C(O)-R5, or -N(R13)-CR14R15(-CR16R17)n-C(O)-R18 rest, which in each case is linked by the nitrogen atom to the central pyrimidin ring; n is 0 or 1; R13 has the meaning given above for R3 or with R14 or R16 possibly forms a heterocycle having between 4 and 7 members; and R5 is an alkyl-, cycloalkyl-, aralkyl-, aryl- or heteroaryl rest, whereby these rests can be substituted with hydroxy-, amino groups or halogen. R14, R15, R16 and R17, independently of each other, are hydrogen, the C alpha radical of a proteinogenic amino acid, alkyl, cycloalkyl, aryl, heteroaryl, aralkyl or heteroaralkyl, and R14 and R15 or alternatively R16 and R17 can together form a carbocycle having between 3 and 7 members; R18 is OH or N(R6R7), where R6 can be H, alkyl, cycloalkyl, aralkyl, aryl or heteroaryl and R7 is a group which, together with the N atom, represents a proteinogenic or non-proteinogenic alpha or beta amino acid or amino acid amide. In addition, R6 and R7 can together form a ring having between 4 and 7 members, which optionally contains heteroatoms such as oxygen, sulphur or nitrogen and is optionally substituted with alkyl, aralkyl, aryl or heteroaryl. The invention further relates to pharmacologically compatible salts and esters of general formula I and the use of these compounds for manufacturing medicinal products.

IPC 1-7 (main, further and additional classification)

C07D 239/00

IPC 8 full level (invention and additional information)

A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61P 9/00 (2006.01); A61P 9/12 (2006.01); A61P 43/00 (2006.01); C07D 239/60 (2006.01); C07D 239/62 (2006.01); C07D 403/04 (2006.01); C07D 403/12 (2006.01)

CPC (invention and additional information)

C07D 239/60 (2013.01)

Citation (search report)

See references of WO 9858915A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

DE 19726427 A1 19981224; AR 013119 A1 20001213; AU 8627898 A 19990104; BR 9810286 A 20000912; CA 2294113 A1 19981230; CN 1268126 A 20000927; EP 0991626 A2 20000412; JP 2002504917 A 20020212; KR 20010014152 A 20010226; TR 9903213 T2 20000621; US 6242455 B1 20010605; WO 9858915 A2 19981230; WO 9858915 A3 19990514; ZA 9805406 B 19991222

INPADOC legal status


2010-06-23 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20100101

2003-11-19 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20031001

2000-04-12 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000124

2000-04-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-04-12 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000124;LT PAYMENT 20000124;LV PAYMENT 20000124;RO PAYMENT 20000124;SI PAYMENT 20000124