EP 1086126 A1 20010328 - Cell-permeable peptide
Title (en)
Cell-permeable peptide
Title (de)
Zell-durchlässige Peptide
Title (fr)
Peptide permeable aux cellules
Publication
Application
Priority
- GB 9901848 W 19990610
- GB 9812376 A 19980610
- GB 9814888 A 19980710
Abstract (en)
[origin: WO9964449A2] The present invention relates to a new method of delivery of molecules into a cell through the use of a modified signal peptide to which a peptide nucleic acid is linked. The signal peptide will comprise at least one positively charged amino acid residue, or functional equivalent thereof. The addition of such positively charged residues can serve as a linker group for the attachment of peptide nucleic acids to the signal peptide thus increasing the number of peptide nucleic acid sequences delivered by the signal peptide and therefore its functional efficiency. Extension of the signal peptide at the C or N terminus through the addition of a single or multiple charged residue or analogues thereof will modify and improve signal peptide delivery function by increasing the solubility and cell permeability characteristics of the signal peptide.
IPC 1-7
IPC 8 full level
A61K 47/48 (2006.01); A61K 48/00 (2006.01); C07K 14/00 (2006.01); C07K 14/50 (2006.01); C12N 15/62 (2006.01); C12N 15/87 (2006.01)
CPC (source: EP)
A61K 47/65 (2017.07); A61K 48/00 (2013.01); C07K 14/003 (2013.01); C07K 14/50 (2013.01); C12N 15/625 (2013.01); C12N 15/87 (2013.01); C07K 2319/10 (2013.01); C07K 2319/60 (2013.01)
Citation (search report)
See references of WO 9964449A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9964449 A2 19991216; WO 9964449 A3 20021024; AU 4281999 A 19991230; EP 1086126 A1 20010328
DOCDB simple family (application)
GB 9901848 W 19990610; AU 4281999 A 19990610; EP 99955476 A 19990610