Global Patent Index - EP 1115889 A4

EP 1115889 A4 20030205 - METHODS TO SELECTIVELY INACTIVATE VIRUSES IN BIOLOGICAL COMPOSITIONS

Title (en)

METHODS TO SELECTIVELY INACTIVATE VIRUSES IN BIOLOGICAL COMPOSITIONS

Title (de)

METHODEN ZUR SELEKTIVEN INAKTIVIERUNG VON VIREN IN BIOLOGISCHEN ZUSAMMENSETZUNGEN

Title (fr)

PROCEDE SELECTIF D'INACTIVATION DE VIRUS DANS DES COMPOSITIONS BIOLOGIQUES

Publication

EP 1115889 A4 20030205 (EN)

Application

EP 99952914 A 19990922

Priority

  • US 9921245 W 19990922
  • US 16103098 A 19980925

Abstract (en)

[origin: WO0018969A1] The invention features a method for inactivating animal viruses in a preparation of purified mammalian cells which, when mature, lack a nucleus (e.g., red blood cells or platelets), that includes contacting the preparation with a selective ethyleneimine oligomer inactivating agent under viral inactivating conditions for a period of time sufficient to inactivate at least some of the animal viruses in the preparation. Also disclosed is a method for removing the ethyleneimine oligomer inactivating agent from a treated biological composition, following viral inactivation without the addition of any quenching agent.

IPC 1-7

C12Q 1/70; C12N 7/06; A61K 31/33; A61L 2/00

IPC 8 full level

A61K 35/14 (2006.01); A61K 35/16 (2006.01); A61K 35/18 (2006.01); A61P 7/08 (2006.01); C12N 7/06 (2006.01); C12R 1/93 (2006.01)

CPC (source: EP)

A61P 7/08 (2017.12); C12N 7/00 (2013.01); C12N 2796/00 (2022.02)

Citation (search report)

  • [XY] WO 9707674 A1 19970306 - PENTOSE PHARMACEUTICALS INC [US], et al
  • [Y] GABLER F R: "CELL PROCESSING USING CROSS-FLOW FILTRATION", DEVELOPMENTS IN INDUSTRIAL MICROBIOLOGY, ELSEVIER SCIENCE BV, AMSTERDAM, NL, vol. 25, August 1993 (1993-08-01), pages 381 - 396, XP002926909, ISSN: 0070-4563
  • [A] BUDOWSKY E I ET AL: "PRINCIPLES OF SELECTIVE INACTIVATION OF THE VIRAL GENOME: DEPENDENCE OF THE RATE OF VIRAL RNA MODIFICATION ON THE NUMBER OF PROTONIZABLE GROUPS IN ETHYLENEIMINE OLIGOMERS", VACCINE RESEARCH, MARY ANN LIEBERT, INC., PUBLISHERS, US, vol. 5, no. 1, 1996, pages 29 - 39, XP002926907
  • See references of WO 0018969A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0018969 A1 20000406; AU 6497099 A 20000417; CA 2345230 A1 20000406; EP 1115889 A1 20010718; EP 1115889 A4 20030205; JP 2002525131 A 20020813

DOCDB simple family (application)

US 9921245 W 19990922; AU 6497099 A 19990922; CA 2345230 A 19990922; EP 99952914 A 19990922; JP 2000572416 A 19990922