Title (en)

COMPOSITIONS AND METHODS FOR IDENTIFYING MAMMALIAN MALONYL COA DECARBOXYLASE INHIBITORS, AGONISTS AND ANTAGONISTS

Title (de)

ZUSAMENSETZUNGEN UND METHODE ZUR IDENTIFIZIERUNG VON INHIBITOREN, AGONISTEN UND ANTAGONISTEN DER MALONYL COA-DECARBOXYLASE VON SÄUGERTIEREN

Title (fr)

COMPOSITIONS ET PROCEDES SERVANT A IDENTIFIER DES INHIBITEURS, AGONISTES ET ANTAGONISTES DE MALONYLE COA DECARBOXYLASE MAMMIFERE

Publication

EP 1127139 A2 20010829 (EN)

Application

EP 99938082 A 19990809

Priority

• CA 9900734 W 19990809
• US 9609398 P 19980811
• US 25120099 A 19990216

Abstract (en)

[origin: WO0009710A2] The present invention relates to the area of fatty acid oxidation, generally to compositions and methods of identifying and testing fatty acid oxidation inhibitors, and in particular, compositions comprising a novel cardiac isoform of MCD, identified to be a key regulator of fatty acid oxidation in the heart. Additionally, nucleotide acid sequences of malonyl CoA decarboxylase genes from the rat pancreas, heart and liver are described. Such sequences and derived products are useful in screening methods for identifying and testing agonists and antagonists of the MCD pathway.

IPC 1-7

C12N 15/60; C12N 9/88; C12Q 1/527

IPC 8 full level

C12N 15/09 (2006.01); C07K 16/40 (2006.01); C12N 9/88 (2006.01); C12N 15/60 (2006.01); C12Q 1/527 (2006.01)

CPC (source: EP KR)

C12N 9/88 (2013.01 - EP); C12Q 1/527 (2013.01 - EP KR); G01N 2500/20 (2013.01 - EP)

Citation (search report)

See references of WO 0009710A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0009710 A2 20000224; WO 0009710 A3 20010607; AU 5272999 A 20000306; AU 774628 B2 20040701; CA 2339088 A1 20000224; EP 1127139 A2 20010829; JP 2002522082 A 20020723; KR 20010085373 A 20010907

DOCDB simple family (application)

CA 9900734 W 19990809; AU 5272999 A 19990809; CA 2339088 A 19990809; EP 99938082 A 19990809; JP 2000565145 A 19990809; KR 20017001831 A 20010212