Global Patent Index - EP 1146909 A4

EP 1146909 A4 20041229 - METHOD OF TREATING CANCER BY RESTORATION OF PP32 FUNCTION

Title (en)

METHOD OF TREATING CANCER BY RESTORATION OF PP32 FUNCTION

Title (de)

VERFAHREN ZUR BEHANDLUNG VON KREBS MITTELS WIEDERHERSTELLUNG DER PP32-FUNKTION

Title (fr)

TRAITEMENT DU CANCER PAR RESTAURATION DE LA FONCTION PP32

Publication

EP 1146909 A4 20041229 (EN)

Application

EP 00905923 A 20000203

Priority

  • US 0002656 W 20000203
  • US 11866799 P 19990203

Abstract (en)

[origin: WO0045852A1] Methods to treat existing cancer or prevent cancer formation by restoration of pp32 function in cells lacking normal pp32 activity or expression are provided. The methods provide for restoration of pp32 either through transfection of cells with DNA expressing normal pp32, administration of an inducer of pp32 activity and/or inhibition of a nuclear phosphatase that is inhibited by pp32.

IPC 1-7

A61K 48/00; A61K 31/00; C12N 15/63; G01N 33/50; G01N 33/567; G01N 33/574

IPC 8 full level

A61K 31/7115 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C12N 15/09 (2006.01); C12Q 1/42 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)

CPC (source: EP)

A61P 35/00 (2017.12); C07K 14/47 (2013.01); C12Q 1/42 (2013.01); G01N 33/5011 (2013.01); A61K 48/00 (2013.01); G01N 2333/916 (2013.01)

Citation (search report)

  • [X] US 5726018 A 19980310 - PASTERNACK GARY R [US]
  • [PX] WO 9929906 A2 19990617 - UNIV JOHNS HOPKINS [US], et al
  • [X] KOCHEVAR G J ET AL: "The structure of a gene encoding PP32R1, a new transforming protein", MOLECULAR BIOLOGY OF THE CELL, vol. 8, no. SUPPL., November 1997 (1997-11-01), & 37TH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR CELL BIOLOGY; WASHINGTON, D.C., USA; DECEMBER 13-17, 1997, pages 137A, XP008037808, ISSN: 1059-1524
  • [PX] DADKOL S S ET AL: "MODULATION OF ONCOGENIC POTENTIAL BY ALTERNATIVE GENE USE IN HUMAN PROSTATE CANCER", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 5, no. 3, March 1999 (1999-03-01), pages 275 - 279, XP002929315, ISSN: 1078-8956
  • [PX] BRODY JONATHAN R ET AL: "Identification of sequences required for inhibition of oncogene-mediated transformation by pp32", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 29, 16 July 1999 (1999-07-16), pages 20053 - 20055, XP002303700, ISSN: 0021-9258
  • [A] DATABASE EMBL 3 April 1997 (1997-04-03), XP002106402, Database accession no. U71084
  • [A] DATABASE EMBL 8 January 1998 (1998-01-08), ...., XP002106403, Database accession no. AF008216
  • [Y] CHEN T-H ET AL: "STRUCTURE OF PP32, AN ACIDIC NUCLEAR PROTEIN WHICH INHIBITS ONCOGENE-INDUCED FORMATION OF TRANSFORMED FOCI", MOLECULAR BIOLOGY OF THE CELL, BETHESDA, MD, US, vol. 7, December 1996 (1996-12-01), pages 2045 - 2056, XP002929314, ISSN: 1059-1524
  • [Y] LI M ET AL: "MOLECULAR IDENTIFICATION OF I PP2A, A NOVEL POTENT HEAT-STABLE INHIBITOR PROTEIN OF PROTEIN PHOSPHATASE 2A", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 35, no. 22, 1996, pages 6998 - 7002, XP002929316, ISSN: 0006-2960
  • [A] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1993, WALENSKY LOREN D ET AL: "A novel M-r 32000 nuclear phosphoprotein is selectively expressed in cells competent for self-renewal", XP002303701, Database accession no. PREV199396138528 & CANCER RESEARCH, vol. 53, no. 19, 1993, pages 4720 - 4726, ISSN: 0008-5472
  • See references of WO 0045852A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0045852 A1 20000810; AU 2751900 A 20000825; CA 2361838 A1 20000810; EP 1146909 A1 20011024; EP 1146909 A4 20041229; JP 2002536346 A 20021029

DOCDB simple family (application)

US 0002656 W 20000203; AU 2751900 A 20000203; CA 2361838 A 20000203; EP 00905923 A 20000203; JP 2000596971 A 20000203