Title (en)

METHOD FOR DETECTING REPLICATION COMPETENT VIRUSES IN THE SERA OF SUBJECTS RECEIVING GENE THERAPY

Title (de)

METHODEN ZUM NACHWEIS VON REPLIKATIONSFÄHIGEN VIREN IM SERUM VON SUBJEKTEN DIE EINE GENTHERARIE ERHALTEN.

Title (fr)

PROCEDE DE DETECTION DE VIRUS APTES A LA REPLICATION DANS LE SERUM DE SUJETS TRAITES PAR THERAPIE GENIQUE

Publication

EP 1240361 A1 20020918 (EN)

Application

EP 00976429 A 20001115

Priority

• KR 0001305 W 20001115
• KR 19990050510 A 19991115

Abstract (en)

[origin: WO0136688A1] The present invention provides a method for detecting replication competent viruses in the sera of subjects receiving gene therapy, the method comprising the step of detecting anti-retroviral antibodies in the sera using a specific antigen. A gene for the antigen exists not in a viral vector for gene therapy but only in a virus genome from which the viral vector originated and the antigen is preferably selected from the group of partial Gag and partial Env proteins of murine leukemia virus. There are also provided antigens whose amino acid sequences include the sequence of SEQ ID NO: 2 or SEQ ID NO: 6, which is of great use in immunoreaction-based RCR detection in view of specificity and sensitivity.

IPC 1-7

G01N 33/569

IPC 8 full level

C07K 16/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/70 (2006.01); G01N 33/53 (2006.01); G01N 33/569 (2006.01)

CPC (source: EP KR)

C07K 16/1036 (2013.01 - EP); C12Q 1/70 (2013.01 - KR)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0136688 A1 20010525; AU 1421201 A 20010530; CN 1411513 A 20030416; EP 1240361 A1 20020918; EP 1240361 A4 20050112; JP 2003515113 A 20030422; JP 3445984 B2 20030916; KR 20000071901 A 20001205; KR 20020089304 A 20021129

DOCDB simple family (application)

KR 0001305 W 20001115; AU 1421201 A 20001115; CN 00817358 A 20001115; EP 00976429 A 20001115; JP 2001538565 A 20001115; KR 19990050510 A 19991115; KR 20027006232 A 20020515