Global Patent Index - EP 1272845 A4

EP 1272845 A4 20030910 - SOLUTION AND CRYSTAL STRUCTURES OF ZipA AND ZipA COMPLEX AND USES THEREOF

Title (en)

SOLUTION AND CRYSTAL STRUCTURES OF ZipA AND ZipA COMPLEX AND USES THEREOF

Title (de)

LÖSUNG UND KRISTALLSTRUKTUREN VON ZIPa UND ZIPa-KOMPLEX SOWIE ANWENDUNGEN DAFÜR

Title (fr)

SOLUTION ET STRUCTURES CRISTALLINES DE ZIPA ET DE COMPLEXE DE ZIPA AINSI QUE LEURS UTILISATIONS

Publication

EP 1272845 A4 20030910 (EN)

Application

EP 01922753 A 20010326

Priority

  • US 0109826 W 20010326
  • US 53677400 A 20000328

Abstract (en)

[origin: WO0173436A1] The present invention relates to the three dimensional solution and crystal structures of the C-terminal domain of ZipA ("ZipA185-328"), as well as the three dimensional crystal structure of ZipA185-328 complexed with a C-terminal region of FtsZ. These structures are critical for the design and selection of potent and selective inhibitors of ZipA/FtsZ complex activity, particularly for use as antibiotic agents against Gram negative bacteria. Also provided by the present invention are the inhibitors identified using the three dimensional structures disclosed herein.

IPC 1-7

G01N 33/53; C07K 1/00

IPC 8 full level

C07K 14/245 (2006.01)

CPC (source: EP)

C07K 14/245 (2013.01); C07K 2299/00 (2013.01)

Citation (search report)

  • [PX] MOY F J ET AL: "Solution structure of ZipA, a crucial component of Escherichia coli cell division.", BIOCHEMISTRY. UNITED STATES 8 AUG 2000, vol. 39, no. 31, 8 August 2000 (2000-08-08), pages 9146 - 9156, XP009008635, ISSN: 0006-2960
  • [PX] HALE C A ET AL: "ZipA-induced bundling of FtsZ polymers mediated by an interaction between C-terminal domains.", JOURNAL OF BACTERIOLOGY. UNITED STATES SEP 2000, vol. 182, no. 18, September 2000 (2000-09-01), pages 5153 - 5166, XP002236592, ISSN: 0021-9193
  • See references of WO 0173436A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0173436 A1 20011004; AU 4951801 A 20011008; CA 2403200 A1 20011004; EP 1272845 A1 20030108; EP 1272845 A4 20030910

DOCDB simple family (application)

US 0109826 W 20010326; AU 4951801 A 20010326; CA 2403200 A 20010326; EP 01922753 A 20010326