EP 1383543 A4 20060621 - USE OF BIOMOLECULAR TARGETS IN THE TREATMENT AND VISUALIZATION OF BRAIN TUMORS
Title (en)
USE OF BIOMOLECULAR TARGETS IN THE TREATMENT AND VISUALIZATION OF BRAIN TUMORS
Title (de)
VERWENDUNG VON BIOMOLEKULAREN TARGETS BEI DER BEHANDLUNG UND VISUALISIERUNG VON HIRNTUMOREN
Title (fr)
UTILISATION DE CIBLES BIOMOLECULAIRES DANS LE TRAITEMENT ET LA VISUALISATION DE TUMEURS CEREBRALES
Publication
Application
Priority
- US 0208992 W 20020322
- US 81670301 A 20010323
- US 98300001 A 20011017
Abstract (en)
[origin: WO02076510A1] The present invention relates to the use of proteins that are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of immunotherapeutic and immunoimaging agents which specifically bind to one or more of the identified brain tumor protein targets. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. The present invention also provides novel splice variants of protein PTP , PTP SM1 and PTP SM2. Nucleic acid probes specific for the spliced mRNA encoding these variants and affinity reagents specific for the novel proteins are also provided.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 45/00 (2006.01); A61K 49/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C12M 1/00 (2006.01); C12M 1/34 (2006.01); C12Q 1/68 (2006.01)
CPC (source: EP)
A61K 49/0002 (2013.01); A61P 35/00 (2017.12)
Citation (search report)
- [PA] WO 0194629 A2 20011213 - AVALON PHARMACEUTICALS [US]
- [DA] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 11 August 2000 (2000-08-11), KROES ROGER A ET AL: "The identification of novel therapeutic targets for the treatment of malignant brain tumors", XP002379786, Database accession no. PREV200000425434 & CANCER LETTERS, vol. 156, no. 2, 11 August 2000 (2000-08-11), pages 191 - 198, ISSN: 0304-3835
- See references of WO 02076510A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02076510 A1 20021003; CA 2439630 A1 20021003; EP 1383543 A1 20040128; EP 1383543 A4 20060621; JP 2004537282 A 20041216
DOCDB simple family (application)
US 0208992 W 20020322; CA 2439630 A 20020322; EP 02726668 A 20020322; JP 2002575022 A 20020322