EP 1644033 A2 20060412 - USE OF INHIBITORS OF DP IV AND APN FOR THE TREATMENT AND PREVENTION OF DERMATOLOGICAL DISEASES INVOLVING THE HYPERPROLIFERATION AND MODIFIED DIFFERENTIATION CONDITIONS OF FIBROBLASTS
Title (en)
USE OF INHIBITORS OF DP IV AND APN FOR THE TREATMENT AND PREVENTION OF DERMATOLOGICAL DISEASES INVOLVING THE HYPERPROLIFERATION AND MODIFIED DIFFERENTIATION CONDITIONS OF FIBROBLASTS
Title (de)
VERWENDUNG VON DP IV- UND APN INHIBITOREN ZUR BEHANDLUNG DERMATOLOGISCHER ERKRANKUNGEN MIT HYPERPROLIFERATION UND VERAENDERTEN DIFFERENZIERUNGSZUSTAENDEN VON FIBROBLASTEN
Title (fr)
UTILISATION DES INHIBITEURS DE LA DP IV ET DE L'APN POUR LA THERAPIE DES MALADIES DERMATOLOGIQUES AVEC HYPERPROLIFERATION ET ETATS DE DIFFERENCIATION MODIFIES DES FIBROBLASTES
Publication
Application
Priority
- EP 2004007377 W 20040706
- DE 10330842 A 20030708
Abstract (en)
[origin: WO2005004906A2] The invention relates to a method for inhibiting the DNA synthesis of human fibroblasts that is necessary for proliferation, by the individual or combined action of inhibitors of alanyl-aminopeptidase (APN) and dipeptidylpeptidase IV (DP IV) that is expressed by said cells. The DNA synthesis (proliferation) of human fibroblasts is inhibited by a dosage-dependent administration of the APN and/or the DP IV. According to the invention, the application of inhibitors of the aforementioned enzyme or of preparations and administrable forms containing said inhibitors is eminently suitable for the treatment and prevention of dermatological diseases involving fibroblastic hyperproliferation and modified differentiation conditions of fibroblasts.
IPC 1-7
IPC 8 full level
A61K 45/06 (2006.01); A61P 17/00 (2006.01)
CPC (source: EP US)
A61K 45/06 (2013.01 - EP US); A61P 11/00 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 17/02 (2017.12 - EP); A61P 17/14 (2017.12 - EP); A61P 19/04 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 43/00 (2017.12 - EP)
Citation (search report)
See references of WO 2005004906A2
Citation (examination)
- WO 0189569 A1 20011129 - INST MEDIZINTECHNOLOGIE MAGDEB [DE], et al
- EP 1289559 B1 20050727 - INST MEDIZINTECHNOLOGIE MAGDEB [DE]
- SEDO A ET AL: "Dipeptidyl peptidase IV-like molecules: homologous proteins or homologous activities?", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM; NL, vol. 1550, no. 2, 17 December 2001 (2001-12-17), pages 107 - 116, XP004330483, ISSN: 0167-4838, DOI: DOI:10.1016/S0167-4838(01)00278-3
- AUGUSTYNS K ET AL: "THE UNIQUE PROPERTIES OF DIPEPTIDYL-PEPTIDASE IV (DPP IV/CD26) AND THE THERAPEUTIC POTENTIAL OF DPP IV INHIBITORS", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 6, no. 4, 1 January 1999 (1999-01-01), pages 311 - 327, XP000870290, ISSN: 0929-8673
- EVANS D M: "Dipeptidyl peptidase IV inhibitors", IDRUGS, CURRENT DRUGS LTD, GB, vol. 5, no. 6, 11 July 2002 (2002-07-11), pages 577 - 585, XP002383468, ISSN: 1369-7056
- ALBISTON ANTHONY L ET AL: "Membrane bound members of the M1 family: More than aminopeptidases", PROTEIN AND PEPTIDE LETTERS, vol. 11, no. 5, October 2004 (2004-10-01), pages 491 - 500, ISSN: 0929-8665
- BAUVOIS BRIGITTE ET AL: "Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects", MEDICINAL RESEARCH REVIEWS, NEW YORK, NY, US, vol. 26, no. 1, 1 January 2006 (2006-01-01), pages 88 - 130, XP007906395, ISSN: 0198-6325, DOI: DOI:10.1002/MED.20044
- XU WENFANG ET AL: "Progress in the development of aminopeptidase n (APN/CD13) inhibitors", CURRENT MEDICINAL CHEMISTRY - ANTI-CANCER AGENTS, vol. 5, no. 3, May 2005 (2005-05-01), pages 281 - 301, XP009145791, ISSN: 1568-0118, DOI: doi:10.2174/1568011053765949
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005004906 A2 20050120; WO 2005004906 A3 20050609; CN 100560129 C 20091118; CN 1819840 A 20060816; DE 10330842 A1 20050210; EP 1644033 A2 20060412; JP 2009513520 A 20090402; US 2007042938 A1 20070222
DOCDB simple family (application)
EP 2004007377 W 20040706; CN 200480019624 A 20040706; DE 10330842 A 20030708; EP 04740701 A 20040706; JP 2006518125 A 20040706; US 56349804 A 20040706