EP 1697410 A1 20060906 - ISOLATED CYTOTOXIC FACTOR ASSOCIATED WITH MULTIPLE SCLEROSIS AND METHOD OF DETECTING SAID CYTOTOXIC FACTOR
Title (en)
ISOLATED CYTOTOXIC FACTOR ASSOCIATED WITH MULTIPLE SCLEROSIS AND METHOD OF DETECTING SAID CYTOTOXIC FACTOR
Title (de)
ISOLIERTER, MIT MULTIPLER SKLEROSE ASSOZIIERTER ZYTOTOXISCHER FAKTOR UND VERFAHREN ZUM NACHWEIS DIESES ZYTOTOXISCHEN FAKTORS
Title (fr)
FACTEUR CYTOTOXIQUE ISOLE ASSOCIE A LA SCLEROSE EN PLAQUES ET PROCEDE DE DETECTION DUDIT FACTEUR CYTOTOXIQUE
Publication
Application
Priority
- FR 2004050748 W 20041222
- FR 0315265 A 20031223
Abstract (en)
[origin: FR2864086A1] The cytotoxic factor is selected from the GM2AP/GM2/MRP14 and mutated GM2AP/GM2/MRP14 hetero-complex in which the mutated GM2AP corresponds to the SEQ ID NO :2 sequence. The detection and/or quantification of such a cytotoxic factor is carried out with a biological sample which is placed in contact with a capture antibody from those which bond specifically with the following proteins or complexes. The cytotoxic factor is selected from the GM2AP/GM2/MRP14 and mutated GM2AP/GM2/MRP14 hetero-complex in which the mutated GM2AP corresponds to the SEQ ID NO :2 sequence. The detection and/or quantification of such a cytotoxic factor is carried out with a biological sample which is placed in contact with a capture antibody from those which bond specifically with the following proteins or complexes: GM2AP, mutated GM2AP, MRP14, the GM2AP/GM2 complex, the mutated GM2AP/GM2 complex, and the MRP14?GM2 complex, where the mutated GM2AP corresponds to the SEQ ID NO :2 sequence. The sample is then placed in contact with a marked detection antibody selected from those that bond specifically with the above proteins, and the cytotoxic factor is detected and/or quantified by detection and/or quantification of the marked detection antibody.
IPC 8 full level
C07K 14/52 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C07K 16/24 (2006.01); C07K 16/30 (2006.01); G01N 33/564 (2006.01)
CPC (source: EP US)
C07K 14/47 (2013.01 - EP US); C07K 14/52 (2013.01 - EP US); C07K 16/18 (2013.01 - EP US); C07K 16/24 (2013.01 - EP US); C07K 16/3084 (2013.01 - EP US); G01N 33/564 (2013.01 - EP US); C07K 2317/32 (2013.01 - EP US); G01N 2800/285 (2013.01 - EP US)
Citation (search report)
See references of WO 2005063810A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
FR 2864086 A1 20050624; EP 1697410 A1 20060906; JP 2008505053 A 20080221; US 2007065881 A1 20070322; US 7700294 B2 20100420; WO 2005063810 A1 20050714
DOCDB simple family (application)
FR 0315265 A 20031223; EP 04816595 A 20041222; FR 2004050748 W 20041222; JP 2006546286 A 20041222; US 58267404 A 20041222