Global Patent Index - EP 1765992 A4

EP 1765992 A4 20090107 - TRUNCATED GALNACT2 POLYPEPTIDES AND NUCLEIC ACIDS

Title (en)

TRUNCATED GALNACT2 POLYPEPTIDES AND NUCLEIC ACIDS

Title (de)

VERKÜRZTE GALNACT2-POLYPEPTIDE UND NUKLEINSÄUREN

Title (fr)

POLYPEPTIDES GALNACT2 TRONQUES ET ACIDES NUCLEIQUES

Publication

EP 1765992 A4 20090107 (EN)

Application

EP 05758682 A 20050603

Priority

  • US 2005019442 W 20050603
  • US 57653004 P 20040603
  • US 59858404 P 20040803

Abstract (en)

[origin: WO2005121331A2] The present invention features compositions and methods related to truncated mutants of GalNAcT2. In particular, the invention features truncated human GalNAcT2 polypeptides. The invention also features nucleic acids encoding such truncated polypeptides, as well as vectors, host cells, expression systems, and methods of expressing and using such polypeptides.

IPC 8 full level

C12N 9/10 (2006.01); C12N 15/54 (2006.01)

CPC (source: EP)

A61P 43/00 (2017.12); C12N 9/1051 (2013.01)

Citation (search report)

  • [DY] BENNETT E P ET AL: "cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 271, no. 29, 19 July 1996 (1996-07-19), pages 17006 - 17012, XP002386961, ISSN: 0021-9258
  • [DY] KUROSAWA N ET AL: "Molecular cloning and expression of GalNAc alpha2,6-Sialyltransferase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 269, no. 2, 14 January 1994 (1994-01-14), pages 1402 - 1409, XP002486638, ISSN: 0021-9258
  • [Y] WANDALL H H ET AL: "Substrate specificities of three members of the human UPD-N-acetyl-alpha-D-galactosamine : Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 272, no. 38, 19 September 1997 (1997-09-19), pages 23503 - 23514, XP002904621, ISSN: 0021-9258
  • [Y] BENNETT ERIC PAUL ET AL: "Cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminlytransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 46, 13 November 1998 (1998-11-13), pages 30472 - 30481, XP002504533, ISSN: 0021-9258
  • [Y] DONADIO S ET AL: "Recognition of cell surface acceptors by two human alpha-2,6-sialyltransferases produced in CHO cells", BIOCHIMIE, MASSON, PARIS, FR, vol. 85, no. 3-4, 1 January 2003 (2003-01-01), pages 311 - 321, XP002397070, ISSN: 0300-9084
  • [A] BOEGGEMAN E E ET AL: "The N-terminal stem region of bovine and human beta1,4-galactosyltransferase I increases the in vitro folding efficiency of their catalytic domain from inclusion bodies", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, vol. 30, no. 2, 1 August 2003 (2003-08-01), pages 219 - 229, XP004439531, ISSN: 1046-5928
  • [A] HOMA F L ET AL: "Isolation and expression of a cDNA clone encoding a bovine UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 268, no. 17, 15 June 1993 (1993-06-15), pages 12609 - 12616, XP002965844, ISSN: 0021-9258
  • See references of WO 2005121331A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR LV MK YU

DOCDB simple family (publication)

WO 2005121331 A2 20051222; WO 2005121331 A3 20070830; WO 2005121331 A8 20060309; WO 2005121331 A9 20060601; EP 1765992 A2 20070328; EP 1765992 A4 20090107; JP 2008512085 A 20080424

DOCDB simple family (application)

US 2005019442 W 20050603; EP 05758682 A 20050603; JP 2007515582 A 20050603