EP 1789798 A4 20090218 - MARKERS FOR AUTOIMMUNE DISEASE DETECTION
Title (en)
MARKERS FOR AUTOIMMUNE DISEASE DETECTION
Title (de)
MARKER FÜR DEN NACHWEIS VON AUTOIMMUNKRANKHEITEN
Title (fr)
MARQUEURS POUR LA DÉTECTION DE MALADIES AUTO-IMMUNES
Publication
Application
Priority
- US 2005028801 W 20050812
- US 60110904 P 20040813
Abstract (en)
[origin: WO2006020899A2] The present invention provides genes and their expression patterns, wherein the expression patterns are associated with autoimmune diseases, particularly with systemic lupus erythematosus (SLE) and Wegener's granulomatosus, ANCA+ vasculitis (WG). The invention provides a group of 1645 genes and a number of sub-groups of the 1645 genes the expression patterns of which are useful in methods of identifying autoimmune diseases, differential diagnosis of autoimmune disease, particularly SLE, and classification of diseases, such as SLE and WG into disease sub-groups that are related to the disease activity. The invention also provides methods for differentiating SLE from other autoimmune diseases. The invention further provides a method for predicting SLE flare-ups by analyzing the expression pattern of a group of genes. The invention provides a fast, accurate, and inexpensive method of continuously monitoring SLE patients throughout their lives for prediction of flare-ups. The invention also provides a fast, accurate and inexpensive way to detect medication induced lupus.
IPC 8 full level
C12Q 1/68 (2006.01)
CPC (source: EP)
C12Q 1/6883 (2013.01); G01N 33/564 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01); G01N 2800/104 (2013.01); G01N 2800/328 (2013.01); Y02A 90/10 (2017.12)
Citation (search report)
- [X] WO 2004046098 A2 20040603 - UNIV VANDERBILT [US], et al
- [X] US 2003148298 A1 20030807 - O' TOOLE MARGOT [US], et al
- [A] WO 03072035 A2 20030904 - GENENTECH INC [US]
- [X] CROW MARY K ET AL: "Microarray analysis of gene expression in lupus.", ARTHRITIS RESEARCH & THERAPY 2003, vol. 5, no. 6, 2003, pages 279 - 287, XP002508586, ISSN: 1478-6362
- [DX] CROW M K ET AL: "MICROARRAY ANALYSIS OF INTERFERON-REGULATED GENES IN SLE", AUTOIMMUNITY, HARWOOD, CHUR, CH, vol. 36, no. 8, 1 December 2003 (2003-12-01), pages 481 - 490, XP008029657, ISSN: 0891-6934
- [X] AFFYMETRIX: "Affimetrix GeneChip Human Genome U133 Array Set HG-U133A", NCBI GEO,, 11 March 2002 (2002-03-11), XP002355386
- See references of WO 2006020899A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006020899 A2 20060223; WO 2006020899 A3 20071115; EP 1789798 A2 20070530; EP 1789798 A4 20090218
DOCDB simple family (application)
US 2005028801 W 20050812; EP 05786543 A 20050812