Global Patent Index - EP 1789798 A4

EP 1789798 A4 2009-02-18 - MARKERS FOR AUTOIMMUNE DISEASE DETECTION

Title (en)

MARKERS FOR AUTOIMMUNE DISEASE DETECTION

Title (de)

MARKER FÜR DEN NACHWEIS VON AUTOIMMUNKRANKHEITEN

Title (fr)

MARQUEURS POUR LA DÉTECTION DE MALADIES AUTO-IMMUNES

Publication

EP 1789798 A4 (EN)

Application

EP 05786543 A

Priority

  • US 2005028801 W
  • US 60110904 P

Abstract (en)

[origin: WO2006020899A2] The present invention provides genes and their expression patterns, wherein the expression patterns are associated with autoimmune diseases, particularly with systemic lupus erythematosus (SLE) and Wegener's granulomatosus, ANCA+ vasculitis (WG). The invention provides a group of 1645 genes and a number of sub-groups of the 1645 genes the expression patterns of which are useful in methods of identifying autoimmune diseases, differential diagnosis of autoimmune disease, particularly SLE, and classification of diseases, such as SLE and WG into disease sub-groups that are related to the disease activity. The invention also provides methods for differentiating SLE from other autoimmune diseases. The invention further provides a method for predicting SLE flare-ups by analyzing the expression pattern of a group of genes. The invention provides a fast, accurate, and inexpensive method of continuously monitoring SLE patients throughout their lives for prediction of flare-ups. The invention also provides a fast, accurate and inexpensive way to detect medication induced lupus.

IPC 8 full level (invention and additional information)

C12Q 1/68 (2006.01)

CPC (invention and additional information)

G01N 33/564 (2013.01); C12Q 1/6883 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01); G01N 2800/104 (2013.01); G01N 2800/328 (2013.01); Y02A 90/24 (2018.01)

Citation (search report)

  • [X] WO 2004046098 A2 20040603 - UNIV VANDERBILT [US], et al
  • [X] US 2003148298 A1 20030807 - O' TOOLE MARGOT [US], et al
  • [A] WO 03072035 A2 20030904 - GENENTECH INC [US]
  • [X] CROW MARY K ET AL: "Microarray analysis of gene expression in lupus.", ARTHRITIS RESEARCH & THERAPY 2003, vol. 5, no. 6, 2003, pages 279 - 287, XP002508586, ISSN: 1478-6362
  • [DX] CROW M K ET AL: "MICROARRAY ANALYSIS OF INTERFERON-REGULATED GENES IN SLE", AUTOIMMUNITY, HARWOOD, CHUR, CH, vol. 36, no. 8, 1 December 2003 (2003-12-01), pages 481 - 490, XP008029657, ISSN: 0891-6934
  • [X] AFFYMETRIX: "Affimetrix GeneChip Human Genome U133 Array Set HG-U133A", NCBI GEO,, 11 March 2002 (2002-03-11), XP002355386

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

EPO simple patent family

WO 2006020899 A2 20060223; WO 2006020899 A3 20071115; EP 1789798 A2 20070530; EP 1789798 A4 20090218

INPADOC legal status


2009-06-03 [18W] WITHDRAWN

- Effective date: 20090424

2009-02-18 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20090121

2008-02-27 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: C12Q 1/68 20060101AFI20080122BHEP

2007-12-26 [R17D] SEARCH REPORT (CORRECTION)

- Effective date: 20071115

2007-11-21 [DAX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT (TO ANY COUNTRY) DELETED

2007-05-30 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20070309

2007-05-30 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

2007-05-30 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Countries: AL BA HR MK YU