EP 1828129 A1 20070905 - HYDROXYPYRIDINONE DERIVATIVES, THEIR METAL COMPLEXES AND THEIR USE IN THE PRODUCTION OF CONJUGATES WITH BIOMOLECULES
Title (en)
HYDROXYPYRIDINONE DERIVATIVES, THEIR METAL COMPLEXES AND THEIR USE IN THE PRODUCTION OF CONJUGATES WITH BIOMOLECULES
Title (de)
HYDROXYPYRIDINON-DERIVATE, DEREN METALLKOMPLEXE UND DEREN VERWENDUNG ZUR HERSTELLUNG VON KONJUGATEN MIT BIOMOLEK]LEN
Title (fr)
DERIVES D'HYDROXYPYRIDINONE, LEURS COMPLEXES METALLIQUES ET LEUR UTILISATION POUR LA PRODUCTION DE CONJUGUES AVEC DES BIOMOLECULES
Publication
Application
Priority
- EP 2005013731 W 20051220
- DE 102004062258 A 20041223
Abstract (en)
[origin: DE102004062258B3] Hydroxypyrimidone, hydroxypyridinone or dihydroxybenzene derivatives (I) are new. Hydroxypyrimidone, hydroxypyridinone or dihydroxybenzene derivatives of formula (I) and their salts are new: (RCO)3AUX (I) R : 2-W2>-3-R1>-5-OZ-4(3H)-oxo-6-pyrimidinyl; 5-W1>-6-W2>-1-R1>-3-OZ-2(1H)-oxo-4-pyridinyl or 6-W1>-5-W2>-4-R2>-2-OZ-3-hydroxyphenyl; Z : H or metal; R1>H or 1-10C (un)saturated (cyclo)alkyl optionally interrupted by 1-3 of O, S and/or NR3> and optionally substituted with 1-4 of OH, 1-2 of COOH (optionally protected), 1-2 of SO3OH (optionally protected), 1-2 of PO3H2, 1-2 of halo and/or 1-2 of oxo; R2>R1>, -OOOH (sic), halo, CONR3>R4>, SO3H or PO3H2; R3>, R4>H or 1-10C (un)saturated (cyclo)alkyl optionally substituted with 1-4 OH groups or interrupted by 1-2 O atoms; W1>, W2>R1> or CONR3>R4>; A : CH(NH)CH2N(CH2CH2NH)2 or CH(NH)CON(CH2CH2NH)2 with NH bonded to COR and CH bonded to U; U : a bond or 1-20C (un)saturated (cyclo)alkylene optionally interrupted by 1-4 each of O, S, N, NR3>, NHCO, CONH and.or OP(O)(OH)O and/or 1-2 of arylene and optionally substituted with 1-3 each of 1-10C (un)saturated (cyclo)alkyl, OH, COOH, aryl, halo, 1-6C (un)saturated (cyclo)alkoxy and/or oxo; X : a group capable of reacting with a biomolecule. An independent claim is also included for a process for preparing (I).
IPC 8 full level
C07D 211/86 (2006.01); A61K 49/10 (2006.01)
CPC (source: EP)
A61K 49/085 (2013.01); A61K 49/10 (2013.01); C07C 235/60 (2013.01); C07D 213/81 (2013.01); C07D 239/52 (2013.01); C07D 401/14 (2013.01)
Citation (search report)
See references of WO 2006069676A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
DE 102004062258 B3 20060105; EP 1828129 A1 20070905; JP 2008525343 A 20080717; WO 2006069676 A1 20060706
DOCDB simple family (application)
DE 102004062258 A 20041223; EP 05818828 A 20051220; EP 2005013731 W 20051220; JP 2007547325 A 20051220