Global Patent Index - EP 1888618 A4

EP 1888618 A4 20090715 - ANALOGS OF GLYCYL-PROLYL-GLUTAMATE

Title (en)

ANALOGS OF GLYCYL-PROLYL-GLUTAMATE

Title (de)

ANALOGA VON GLYCYL-PROLYL-GLUTAMAT

Title (fr)

ANALOGUES DE GLYCYL-PROLYL-GLUTAMATE

Publication

EP 1888618 A4 20090715 (EN)

Application

EP 06770950 A 20060523

Priority

  • US 2006019909 W 20060523
  • US 68381305 P 20050523

Abstract (en)

[origin: WO2006127702A2] Embodiments of this invention include novel analogs of Glycyl-Prolyl-Glutamate (GPE) and compositions containing such analogs of GPE. Of these, certain analogs have modified proline residues. Other embodiments of this invention include uses of analogs of GPE to protect neural cells from degeneration and/or death in response to injury or disease. Disorders treatable with compounds and compositions of this invention include hypoxia/ischemia, toxic injury, and chronic neurodegenerative disorders including Parkinson's disease.

IPC 8 full level

C07K 5/08 (2006.01); A61P 25/00 (2006.01); A61P 27/00 (2006.01); A61P 29/00 (2006.01)

CPC (source: EP)

A61K 38/06 (2013.01); A61K 45/06 (2013.01); A61P 9/10 (2017.12); A61P 21/00 (2017.12); A61P 25/00 (2017.12); A61P 25/02 (2017.12); A61P 25/08 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 27/00 (2017.12); A61P 29/00 (2017.12); A61P 43/00 (2017.12); C07K 5/0806 (2013.01); C07K 5/0808 (2013.01)

Citation (search report)

  • [XY] WO 02094856 A2 20021128 - NEURONZ LTD [NZ], et al
  • [X] ALONSO DE DIEGO S A ET AL: "Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 15, no. 9, 2 May 2005 (2005-05-02), pages 2279 - 2283, XP025313633, ISSN: 0960-894X, [retrieved on 20050502]
  • [X] LAI MICHELLE Y H ET AL: "Synthesis and pharmacological evaluation of glycine-modified analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE).", BIOORGANIC & MEDICINAL CHEMISTRY 17 JAN 2005, vol. 13, no. 2, 17 January 2005 (2005-01-17), pages 533 - 548, XP002528274, ISSN: 0968-0896
  • [X] MAEHASHI K ET AL: "Isolation of peptides from an enzymatic hydrolysate of food proteins and characterization of their taste properties.", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY MAR 1999, vol. 63, no. 3, March 1999 (1999-03-01), pages 555 - 559, XP002528276, ISSN: 0916-8451
  • [X] PARK JUNG-NIM ET AL: "Taste effects of oligopeptides in a Vietnamese fish sauce", FISHERIES SCIENCE (TOKYO), vol. 68, no. 4, August 2002 (2002-08-01), pages 921 - 928, XP002528277, ISSN: 0919-9268
  • [X] GILLESSEN D ET AL: "[Syntheses of thyrotropin-releasing hormones (TRH) (Schaf) and related peptides]", HELVETICA CHIMICA ACTA 1970, vol. 53, no. 1, 1970, pages 63 - 72, XP002528278, ISSN: 0018-019X
  • [X] SLOOTSTRA J W ET AL: "STRUCTURAL ASPECTS OF ANTIBODY-ANTIGEN INTERACTION REVEALED THROUGH SMALL RANDOM PEPTIDE LIBRARIES", MOLECULAR DIVERSITY, ESCOM SCIENCE PUBLISHERS, LEIDEN, NL, vol. 1, no. 2, 1 January 1995 (1995-01-01), pages 87 - 96, XP008065429, ISSN: 1381-1991
  • [Y] TROTTER NICHOLAS S ET AL: "Synthesis and neuroprotective activity of analogues of glycyl-L-prolyl-L-glutamic acid (GPE) modified at the alpha-carboxylic acid.", BIOORGANIC & MEDICINAL CHEMISTRY 17 JAN 2005, vol. 13, no. 2, 17 January 2005 (2005-01-17), pages 501 - 517, XP002528275, ISSN: 0968-0896
  • [Y] BRIMBLE MARGARET A ET AL: "Synthesis and pharmacological evaluation of side chain modified glutamic acid analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE).", BIOORGANIC & MEDICINAL CHEMISTRY 17 JAN 2005, vol. 13, no. 2, 17 January 2005 (2005-01-17), pages 519 - 532, XP002528279, ISSN: 0968-0896
  • [PX] ALONSO DE DIEGO S A ET AL: "The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 16, no. 13, 1 July 2006 (2006-07-01), pages 3396 - 3400, XP025107379, ISSN: 0960-894X, [retrieved on 20060701]
  • See references of WO 2006127702A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2006127702 A2 20061130; WO 2006127702 A3 20070614; EP 1888618 A2 20080220; EP 1888618 A4 20090715; JP 2008545697 A 20081218

DOCDB simple family (application)

US 2006019909 W 20060523; EP 06770950 A 20060523; JP 2008513622 A 20060523