EP 1931693 A2 20080618 - PROCESS FOR PREPARING GEMCITABINE AND ASSOCIATED INTERMEDIATES
Title (en)
PROCESS FOR PREPARING GEMCITABINE AND ASSOCIATED INTERMEDIATES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON GEMCITABIN UND DAMIT IN ZUSAMMENHANG STEHENDEN ZWISCHENPRODUKTEN
Title (fr)
PROCEDE POUR PREPARER LA GEMCITABINE ET DES INTERMEDIAIRES ASSOCIES
Publication
Application
Priority
- US 2006033431 W 20060828
- US 71221705 P 20050829
Abstract (en)
[origin: WO2007027564A2] Provided is a process for preparing gemcitabine or a salt thereof, which preferably includes removing at least a substantial portion of the a anomer of a N-1-protected-2'-deoxy-2',2'-difluoro-cytidine-3',5'-diester from an anomeric mixture thereof; removing the 3'-ester, the 5'-ester and the N-protecting group; and optionally forming a salt. The 3'-ester and 5'-ester can be the same or different and at least one of the esters preferably is cinnamoyl, benzoyl, 1-naphthoyl, 1-naphthylmethylcarbonyl, 2-methylbenzylcarbonyl, 4-methylbenzylcarbonyl or 9-fluorenylmethyloxycarbonyl ester. Also provided are novel intermediates, including but not limited to 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-diesters, and methods of producing such intermediates.
IPC 8 full level
C07H 19/19 (2006.01)
CPC (source: EP KR)
A61P 35/00 (2017.12 - EP); C07H 19/067 (2013.01 - EP); C07H 19/073 (2013.01 - KR); C07H 19/19 (2013.01 - KR); Y02P 20/55 (2015.11 - EP)
Citation (search report)
See references of WO 2007027564A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2007027564 A2 20070308; WO 2007027564 A3 20070607; CN 101296934 A 20081029; EP 1931693 A2 20080618; JP 2009506118 A 20090212; KR 20080039502 A 20080507
DOCDB simple family (application)
US 2006033431 W 20060828; CN 200680039700 A 20060828; EP 06802423 A 20060828; JP 2008529146 A 20060828; KR 20087006825 A 20080320