EP 2125723 A1 20091202 - 6-SUBSTITUTED INDOLE-3-CARBOXYLIC ACID AMIDE COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY
Title (en)
6-SUBSTITUTED INDOLE-3-CARBOXYLIC ACID AMIDE COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY
Title (de)
BIOLOGISCHE AKTIVITÄT VON 6-SUBSTITUIERTEN INDOL-3-CARBOXYLSÄUREAMIDVERBINDUNGEN MIT SPHINGOSIN-1-PHOSPHATREZEPTORANTAGONISTEN
Title (fr)
COMPOSÉ AMIDE D'ACIDE INDOLE-3-CARBOXYLIQUE 6-SUBSTITUÉ AYANT UNE ACTIVITÉ BIOLOGIQUE D'ANTAGONISTE DU RÉCEPTEUR DE SPHINGOSINE-1-PHOSPHATE (S1P)
Publication
Application
Priority
- US 2008050695 W 20080110
- US 88447007 P 20070111
Abstract (en)
[origin: WO2008089015A1] The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1 -phosphate receptor agonist and or antagonist biological activity: Formula (I) and wherein the variables Y, R<SUP>4</SUP>, n, o, A, A<SUP>1</SUP>, A<SUP>2</SUP>, X, Z, R<SUP>1</SUP>, R<SUP>3</SUP>, R<SUP>2</SUP>, p, q and r are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing
IPC 8 full level
C07D 209/42 (2006.01); A61K 31/404 (2006.01); A61P 27/00 (2006.01); C07D 401/06 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01)
CPC (source: EP KR)
A61K 31/404 (2013.01 - KR); A61P 27/00 (2017.12 - EP); A61P 31/10 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 37/08 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 209/42 (2013.01 - EP); C07D 401/06 (2013.01 - EP KR); C07D 401/12 (2013.01 - EP); C07D 405/12 (2013.01 - EP); C07D 405/14 (2013.01 - EP KR)
Citation (search report)
See references of WO 2008089015A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008089015 A1 20080724; AU 2008206495 A1 20080724; CA 2674946 A1 20080724; CN 101668741 A 20100310; EP 2125723 A1 20091202; JP 2010515750 A 20100513; KR 20090101307 A 20090924; MX 2009007334 A 20090715
DOCDB simple family (application)
US 2008050695 W 20080110; AU 2008206495 A 20080110; CA 2674946 A 20080110; CN 200880007131 A 20080110; EP 08727502 A 20080110; JP 2009545669 A 20080110; KR 20097016762 A 20080110; MX 2009007334 A 20080110