EP 2282993 A1 20110216 - PROCESS FOR PREPARING 3-INDOLYL FATTY ACID AMIDES WITH SATURATED, UNSATURATED OR HYDROXY FATTY ACIDS
Title (en)
PROCESS FOR PREPARING 3-INDOLYL FATTY ACID AMIDES WITH SATURATED, UNSATURATED OR HYDROXY FATTY ACIDS
Title (de)
VERFAHREN ZUR HERSTELLUNG VON 3-INDOLYL-FETTSÄUREAMIDEN MIT GESÄTTIGTEN, UNGESÄTTIGTEN ODER HYDROXY-FETTSÄUREN
Title (fr)
PROCÉDÉ DE PRÉPARATION D'AMIDES D'ACIDES GRAS 3-INDOLYLÉS AVEC DES ACIDES GRAS SATURÉS, INSATURÉS OU HYDROXYLÉS
Publication
Application
Priority
- EP 2009056244 W 20090522
- DE 102008025893 A 20080526
Abstract (en)
[origin: WO2009144175A1] The invention relates to a process for preparing fatty acid amides by reacting a fatty acid and an amine, especially serotonin as well as tryptamine, tyramine and derivatives thereof, in the presence of a coupling reagent which is capable of activating the carboxylic acid, and of a preferably apolar, aprotic solvent. The coupling reagents are especially selected from phosphonium salts, uronium and/or guanidinium salts. Surprisingly, there is no need to protect hydroxyl groups and other reactive groups in the amine.
IPC 8 full level
C07D 209/14 (2006.01); C07C 231/02 (2006.01); C07D 209/16 (2006.01)
CPC (source: EP)
C07D 209/14 (2013.01); C07D 209/16 (2013.01)
Citation (search report)
See references of WO 2009144175A1
Citation (examination)
- WO 2009132051 A1 20091029 - SIGNUM BIOSCIENCES INC [US], et al
- GIORGIO ORTAR ET AL: "New N -Arachidonoylserotonin Analogues with Potential "Dual" Mechanism of Action against Pain", JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, no. 26, 1 December 2007 (2007-12-01), pages 6554 - 6569, XP055054980, ISSN: 0022-2623, DOI: 10.1021/jm070678q
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA RS
DOCDB simple family (publication)
DE 102008025893 A1 20091203; DE 102008025893 B4 20140918; EP 2282993 A1 20110216; WO 2009144175 A1 20091203
DOCDB simple family (application)
DE 102008025893 A 20080526; EP 09753830 A 20090522; EP 2009056244 W 20090522