EP 2379714 A1 20111026 - IMPROVED BIOCATALYSTS FOR MANUFACTURING DULOXETINE ALCOHOL
Title (en)
IMPROVED BIOCATALYSTS FOR MANUFACTURING DULOXETINE ALCOHOL
Title (de)
VERBESSERTE BIOKATALYSATOREN ZUR HERSTELLUNG VON DULOXETINALKOHOL
Title (fr)
BIOCATALYSEURS AMÉLIORÉS POUR LA FABRICATION D'ALCOOL DE DULOXÉTINE
Publication
Application
Priority
- EP 2009067341 W 20091216
- EP 08172003 A 20081217
- EP 09784086 A 20091216
Abstract (en)
[origin: WO2010079068A1] The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contain said sequences; to a method for the biocatalytic synthesis of substituted, optically active alcohols and to the use of said mutants; and particularly to a method for manufacturing duloxetine alcohol or duloxetine, comprising a synthesis step catalyzed biocatalytic by said mutants.
IPC 8 full level
C12N 9/04 (2006.01); C12P 7/02 (2006.01); C12P 7/22 (2006.01); C12P 7/26 (2006.01); C12P 17/00 (2006.01); C12P 17/04 (2006.01)
CPC (source: EP US)
C12N 9/0006 (2013.01 - EP US); C12P 7/02 (2013.01 - EP US); C12P 7/22 (2013.01 - EP US); C12P 17/00 (2013.01 - EP US)
Citation (search report)
See references of WO 2010079068A1
Citation (examination)
A. PENNACCHIO ET AL: "Purification and Characterization of a Novel Recombinant Highly Enantioselective Short-Chain NAD(H)-Dependent Alcohol Dehydrogenase from Thermus thermophilus", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 74, no. 13, 1 July 2008 (2008-07-01), pages 3949 - 3958, XP055123056, ISSN: 0099-2240, DOI: 10.1128/AEM.00217-08
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010079068 A1 20100715; CA 2747058 A1 20100715; CN 102317450 A 20120111; EP 2379714 A1 20111026; IL 213599 A0 20110731; JP 2012511922 A 20120531; MX 2011006464 A 20110915; TW 201028479 A 20100801; US 2011250655 A1 20111013; US 8658400 B2 20140225
DOCDB simple family (application)
EP 2009067341 W 20091216; CA 2747058 A 20091216; CN 200980156763 A 20091216; EP 09784086 A 20091216; IL 21359911 A 20110616; JP 2011541415 A 20091216; MX 2011006464 A 20091216; TW 98143403 A 20091217; US 200913140255 A 20091216