Global Patent Index - EP 2635107 A4

EP 2635107 A4 20140423 - PAPAVER BRACTEATUM WITH MODIFIED ALKALOID CONTENT

Title (en)

PAPAVER BRACTEATUM WITH MODIFIED ALKALOID CONTENT

Title (de)

ARMENISCHER MOHN MIT MODIFIZIERTEM ALKALOIDGEHALT

Title (fr)

PAPAVER BRACTEATUM À TENEUR EN ALCALOÏDES MODIFIÉE

Publication

EP 2635107 A4 20140423 (EN)

Application

EP 11837323 A 20111031

Priority

  • AU 2010904872 A 20101101
  • AU 2011001400 W 20111031

Abstract (en)

[origin: WO2012058714A1] The present invention relates to genetically modified plants of the species Papaver bracteatum wherein the type or amount of one or more alkaloids produced by the plants has been modified. Specifically, the genetically modified plants have an increased expression of one or more of thebaine 6-O-demethylase, codeine O- demethylase and/or codeinone reductase relative to wild type P. bracteatum such that the genetically modified poppy plants produce an increased quantity of an alkaloid selected from codeine, oripavine and/or morphine relative to a wild type P. bracteatum. Also provided are progeny plants having the genetically modified poppy plants described above as a parent; mutant or derivative plants of the aforementioned plants; reproductive material derived from, straw produced from, straw concentrate produced from, latex derived from, or one or more isolated cells derived from, the aforementioned plants. Methods for producing an alkaloid from the aforementioned plants are also provided, together with nucleic acid and amino acid sequence variants of the 6-O-demethylase and codeine O-demethylase genes.

IPC 8 full level

A01H 5/08 (2006.01); A01H 5/10 (2006.01); C07D 221/28 (2006.01); C07D 489/02 (2006.01); C12N 15/53 (2006.01)

CPC (source: EP)

C07D 489/02 (2013.01); C12N 9/0004 (2013.01); C12N 9/0006 (2013.01); C12N 9/0071 (2013.01); C12N 15/8243 (2013.01); C12P 17/18 (2013.01); C12Y 101/01247 (2013.01); C12Y 114/11031 (2013.01); C12Y 114/11032 (2013.01)

Citation (search report)

  • [YD] WO 9802033 A1 19980122 - TASMANIAN ALKALOIDS PTY LTD [AU], et al
  • [Y] WO 2009092134 A1 20090730 - TPI ENTPR PTY LTD [AU], et al
  • [YD] BROCHMANN-HANSSEN E ET AL: "BIOSYNTHESIS OF MORPHINE ALKALOIDS IN PAPAVER-BRACTEATUM", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 67, no. 1, 1978, pages 103 - 106, XP002721215, ISSN: 0022-3549
  • [Y] SARA ROSTAMPOUR ET AL: "Influence of Agrobacterium rhizogenes on induction of hairy roots and benzylisoquinoline alkaloids production in Persian poppy (Papaver bracteatum Lindl.): preliminary report", WORLD JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, vol. 25, no. 10, 20 June 2009 (2009-06-20), pages 1807 - 1814, XP019734669, ISSN: 1573-0972, DOI: 10.1007/S11274-009-0081-8
  • [T] SHARAFI ALI ET AL: "Metabolic engineering of morphinan alkaloids by over-expression of codeinone reductase in transgenic hairy roots of Papaver bracteatum, the Iranian poppy", BIOTECHNOLOGY LETTERS, vol. 35, no. 3, March 2013 (2013-03-01), pages 445 - 453, XP002721216
  • See references of WO 2012058714A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2012058714 A1 20120510; EP 2635107 A1 20130911; EP 2635107 A4 20140423

DOCDB simple family (application)

AU 2011001400 W 20111031; EP 11837323 A 20111031