EP 3174904 A1 20170607 - METHOD FOR PRODUCING VARIANTS HAVING AN FC WITH IMPROVED SIALYLATION
Title (en)
METHOD FOR PRODUCING VARIANTS HAVING AN FC WITH IMPROVED SIALYLATION
Title (de)
VERFAHREN ZUR HERSTELLUNG VON VARIANTEN MIT EINEM FC MIT VERBESSERTER SIALYLIERUNG
Title (fr)
PROCÉDÉ DE PRODUCTION DE VARIANTS AYANT UN FC PRÉSENTANT UNE SIALYLATION AMÉLIORÉE
Publication
Application
Priority
- FR 1457504 A 20140801
- FR 2015052123 W 20150731
Abstract (en)
[origin: WO2016016586A1] The present invention relates to a method for increasing the sialylation of an Fc fragment, comprising a step of mutating at least one amino acid chosen from the amino acids in positions 240 to 243, 258 to 267 and 290 to 305 of said Fc fragment, the numbering being that of the EU index or equivalent in Kabat. The present invention also relates to a method for producing a variant of a parent polypeptide comprising an Fc fragment, said variant having improved sialylation of said Fc fragment relative to the parent polypeptide, which comprises a step of mutating at least one amino acid chosen from the amino acids in positions 240 to 243, 258 to 267 and 290 to 305 of said Fc fragment, the numbering being that of the EU index or equivalent in Kabat.
IPC 8 full level
C07K 19/00 (2006.01)
CPC (source: CN EP KR US)
C07K 16/00 (2013.01 - EP KR US); C07K 16/2887 (2013.01 - CN EP KR US); C07K 16/34 (2013.01 - CN EP KR US); C07K 2317/41 (2013.01 - CN EP KR US); C07K 2317/52 (2013.01 - CN EP KR US); C07K 2317/71 (2013.01 - US); C07K 2317/90 (2013.01 - CN EP KR US); C07K 2317/94 (2013.01 - US); C07K 2319/30 (2013.01 - CN EP KR US); C07K 2319/90 (2013.01 - CN EP KR US)
Citation (search report)
See references of WO 2016016586A1
Citation (examination)
- WO 2011122011 A2 20111006 - CHUGAI PHARMACEUTICAL CO LTD [JP], et al
- WO 2008150494 A1 20081211 - XENCOR INC [US], et al
- EP 2679681 A1 20140101 - CHUGAI PHARMACEUTICAL CO LTD [JP]
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2016016586 A1 20160204; AU 2015295090 A1 20170216; BR 112017001966 A2 20171121; CA 2956822 A1 20160204; CN 106573978 A 20170419; EP 3174904 A1 20170607; FR 3024453 A1 20160205; FR 3024453 B1 20180629; JP 2017522040 A 20170810; KR 20170035923 A 20170331; MX 2017001516 A 20170519; US 2017260254 A1 20170914
DOCDB simple family (application)
FR 2015052123 W 20150731; AU 2015295090 A 20150731; BR 112017001966 A 20150731; CA 2956822 A 20150731; CN 201580041852 A 20150731; EP 15759880 A 20150731; FR 1457504 A 20140801; JP 2017505476 A 20150731; KR 20177002628 A 20150731; MX 2017001516 A 20150731; US 201515500105 A 20150731