Global Patent Index - EP 3863615 A4

EP 3863615 A4 20220803 - METHODS FOR THE TREATMENT OF SOLID TUMOR CANCERS USING ILLUDINS AND BIOMARKERS

Title (en)

METHODS FOR THE TREATMENT OF SOLID TUMOR CANCERS USING ILLUDINS AND BIOMARKERS

Title (de)

VERFAHREN ZUR BEHANDLUNG VON KREBSEN MIT SOLIDEN TUMOREN UNTER VERWENDUNG VON ILLUDINEN UND BIOMARKERN

Title (fr)

PROCÉDÉS DE TRAITEMENT DE CANCERS À TUMEUR SOLIDE À L'AIDE D'ILLUDINES ET DE BIOMARQUEURS

Publication

EP 3863615 A4 20220803 (EN)

Application

EP 19872565 A 20191014

Priority

  • US 201862745382 P 20181014
  • US 2019056039 W 20191014

Abstract (en)

[origin: WO2020081414A1] Methods for determining the likelihood that a subject suffering from a solid tumor cancer will benefit from treatment with an illudin are disclosed herein. Further, there are also methods for treatment based on such determination. In several embodiments, markers prostaglandin reductase 1 (PTGR1), Protein Tyrosine Phosphatase Non-Receptor Type 14 (PTPN14), Aspartate Beta- Hydroxylase (ASPH) together with one or more genes or alone may be used to enhance or guide treatment with an illudin. In certain embodiments, the protein or gene may be expressed or methylated.

IPC 8 full level

A61K 31/122 (2006.01); A61K 31/17 (2006.01); A61P 35/00 (2006.01); C07C 239/14 (2006.01); C12Q 1/686 (2018.01); C12Q 1/6886 (2018.01)

CPC (source: EP)

A61K 31/122 (2013.01); A61K 31/17 (2013.01); A61P 35/00 (2018.01); C12Q 1/6886 (2013.01); C12Q 2600/158 (2013.01)

Citation (search report)

  • [XY] US 9725769 B1 20170808 - KNUDSEN STEEN [US]
  • [IY] WO 2007019308 A2 20070215 - UNIV CALIFORNIA [US], et al
  • [I] WO 2018170230 A1 20180920 - MEMORIAL SLOAN KETTERING CANCER CENTER [US]
  • [I] STAAKE MICHAEL D ET AL: "Hydroxyurea derivatives of irofulven with improved antitumor efficacy", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 26, no. 7, 13 February 2016 (2016-02-13), pages 1836 - 1838, XP029453930, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2016.02.028
  • [I] MARINA TANASOVA ET AL: "Chemistry and Biology of Acylfulvenes: Sesquiterpene-Derived Antitumor Agents", CHEMICAL REVIEWS, vol. 112, no. 6, 6 April 2012 (2012-04-06), US, pages 3578 - 3610, XP055665990, ISSN: 0009-2665, DOI: 10.1021/cr2001367
  • See also references of WO 2020081414A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2020081414 A1 20200423; AU 2019361781 A1 20210603; CA 3116552 A1 20200423; CN 113194934 A 20210730; EP 3863615 A1 20210818; EP 3863615 A4 20220803; JP 2022513349 A 20220207

DOCDB simple family (application)

US 2019056039 W 20191014; AU 2019361781 A 20191014; CA 3116552 A 20191014; CN 201980067429 A 20191014; EP 19872565 A 20191014; JP 2021545268 A 20191014