EP 3887380 A1 20211006 - ANTI-CANCER ACTIVITIES OF A NEW FAMILY OF ETHACRYNIC ACID DERIVATIVES
Title (en)
ANTI-CANCER ACTIVITIES OF A NEW FAMILY OF ETHACRYNIC ACID DERIVATIVES
Title (de)
ANTI-KREBS-AKTIVITÄTEN EINER NEUEN FAMILIE VON ETACRYNSÄUREDERIVATEN
Title (fr)
ACTIVITÉS ANTICANCÉREUSES D'UNE NOUVELLE FAMILLE DES DÉRIVÉS DE L'ACIDE ETHACRYNIQUE
Publication
Application
Priority
- MA 44038 A 20181129
- MA 2019000013 W 20191129
Abstract (en)
[origin: WO2020111921A1] The present invention relates to a new class of small anti-cancer molecules derived from ethacrynic acid (symbolized by AE). The invention relates to the in vitro and in vivo anti-cancer activities and to the methods for producing the new AE family. New AE analogues were synthesized and then the in vitro cytotoxic activities thereof were evaluated on the P815 tumour cell line using the MTT test. The AE derivative which exhibited the best in vitro cytotoxicity was then tested in vivo using the DBA2/P815 (H2d) mouse model. At 30 mg/kg, the effective dose, the animals showed general tolerance with a percentage survival of around 80%, and no significant weight loss was observed.
IPC 8 full level
C07F 9/6509 (2006.01); A61K 31/495 (2006.01); A61K 31/6615 (2006.01); A61P 35/00 (2006.01); C07D 295/185 (2006.01)
CPC (source: EP US)
A61K 31/495 (2013.01 - EP); A61P 35/00 (2017.12 - EP US); C07D 295/185 (2013.01 - EP); C07F 9/650952 (2013.01 - EP US)
Citation (search report)
See references of WO 2020111921A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2020111921 A1 20200604; EP 3887380 A1 20211006; MA 44038 A1 20200630; MA 44038 B1 20201028; US 2022024957 A1 20220127
DOCDB simple family (application)
MA 2019000013 W 20191129; EP 19839176 A 20191129; MA 44038 A 20181129; US 201917297252 A 20191129