EP 3898968 A1 20211027 - NUCLEIC ACID ENCODED CHEMICAL LIBRARIES
Title (en)
NUCLEIC ACID ENCODED CHEMICAL LIBRARIES
Title (de)
NUKLEINSÄURECODIERTE CHEMISCHE BIBLIOTHEKEN
Title (fr)
BIBLIOTHÈQUES CHIMIQUES CODÉES PAR L'ACIDE NUCLÉIQUE
Publication
Application
Priority
- GB 201821109 A 20181221
- EP 2019086831 W 20191220
Abstract (en)
[origin: WO2020128064A1] This invention relates to the production of nucleic acid encoded chemical libraries using a population of first conjugates comprising a first nucleic strand coupled to a first reactive group and a first set of one or more chemical moieties at a first end and a population of second conjugates comprising a second nucleic strand coupled to a second reactive group and a second set of one or more chemical moieties. The first and second nucleic acid strands are hybridised together to produce a population of double stranded molecules having the first and second sets of chemical moieties at an end thereof, and the first and second reactive groups are then reacted to covalently link the first and second sets of chemical moieties and produce cyclised pharmacophores coupled to the double stranded molecules. The population of double stranded molecules form a chemical library. Nucleic acid encoded chemical libraries and their production and use are provided.
IPC 8 full level
C12N 15/10 (2006.01)
CPC (source: EP)
C12N 15/1068 (2013.01)
Citation (search report)
See references of WO 2020128064A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2020128064 A1 20200625; EP 3898968 A1 20211027; GB 201821109 D0 20190206
DOCDB simple family (application)
EP 2019086831 W 20191220; EP 19832693 A 20191220; GB 201821109 A 20181221