EP 4031657 A1 20220727 - OPTIMIZED TETRAHYDROCANNABINOLIC ACID (THCA) SYNTHASE POLYPEPTIDES
Title (en)
OPTIMIZED TETRAHYDROCANNABINOLIC ACID (THCA) SYNTHASE POLYPEPTIDES
Title (de)
OPTIMIERTE POLYPEPTIDE FÜR TETRAHYDROCANNABINSÄURE (THCA)-SYNTHASE
Title (fr)
POLYPEPTIDES OPTIMISÉS DE L'ACIDE TÉTRAHYDROCANNABIDIOLIQUE (THCA) SYNTHASE
Publication
Application
Priority
- US 201962902300 P 20190918
- US 2020051261 W 20200917
Abstract (en)
[origin: WO2021055597A1] The present disclosure provides engineered variants of a tetrahydrocannabinolic acid synthase (THCAS) polypeptide comprising an amino acid sequence of SEQ ID NO:44 with one or more amino acid substitutions, nucleic acids comprising nucleotide sequences encoding said engineered variants, methods of making modified host cells comprising said nucleic acids, modified host cells expressing said engineered variants, methods of producing cannabinoids or cannabinoid derivatives, and methods of screening engineered variants of the tetrahydrocannabinolic acid synthase (THCAS) polypeptide.
IPC 8 full level
C12N 9/02 (2006.01); C12N 15/52 (2006.01); C12N 15/82 (2006.01); C12P 7/22 (2006.01); C12P 7/42 (2006.01); C12P 17/06 (2006.01)
CPC (source: EP IL)
C07K 14/415 (2013.01 - EP IL); C12N 9/0004 (2013.01 - EP IL); C12N 15/52 (2013.01 - EP IL); C12P 7/42 (2013.01 - EP IL); C12P 17/06 (2013.01 - EP IL); C12Y 121/03007 (2015.07 - EP IL)
Citation (search report)
See references of WO 2021055597A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2021055597 A1 20210325; AU 2020349513 A1 20220505; BR 112022004797 A2 20220621; CA 3152803 A1 20210325; CN 115038786 A 20220909; EP 4031657 A1 20220727; IL 291328 A 20220501; JP 2022548904 A 20221122; MX 2022003203 A 20220608
DOCDB simple family (application)
US 2020051261 W 20200917; AU 2020349513 A 20200917; BR 112022004797 A 20200917; CA 3152803 A 20200917; CN 202080078001 A 20200917; EP 20786122 A 20200917; IL 29132822 A 20220313; JP 2022517341 A 20200917; MX 2022003203 A 20200917