EP 4061393 A1 20220928 - METHOD FOR THE DEVELOPMENT OF A DELIVERY PLATFORM TO PRODUCE DELIVERABLE PTD-IVT-MRNA THERAPEUTICS
Title (en)
METHOD FOR THE DEVELOPMENT OF A DELIVERY PLATFORM TO PRODUCE DELIVERABLE PTD-IVT-MRNA THERAPEUTICS
Title (de)
VERFAHREN ZUR ENTWICKLUNG EINER VERABREICHUNGSPLATTFORM ZUM PRODUZIEREN VON VERABREICHUNGSFÄHIGEN PTD-IVT-MRNA-THERAPEUTIKA
Title (fr)
PROCÉDÉ POUR LE DÉVELOPPEMENT D'UNE PLATEFORME D'ADMINISTRATION POUR PRODUIRE DES AGENTS THÉRAPEUTIQUES À BASE DE PTD-IVT-ARNM ADMINISTRABLES
Publication
Application
Priority
- GR 20190100504 A 20191111
- GR 2020000059 W 20201111
Abstract (en)
[origin: WO2021094792A1] This invention relates to a method for the production of a delivery platform to produce deliverable PTD-IVT-mRNA therapeutics, wherein Protein Transduction Domains (PTDs) technology is used as a transduction delivery platform for therapeutic IVT-mRNAs and the development of said delivery platform is accomplished by a covalent chemical reaction between said IVT-mRNA molecules and a selected transduction peptide PFVYLI, Said method is remarkable by the combination of the PTD technology with IVT-mRNA, via covalent chemical binding-conjugation, wherein said IVT-mRNA is conjugated to a PTD, by means whereof the stability of the connection between the PTD transporter and the therapeutic IVT-mRNA molecule is achieved, thus providing very stable IVT-mRNA:PTD complex. Said IVT-mRNAs constituting therapeutic molecules, are submitted to an intracellular delivery through said covalently conjugation to the appropriate PTD, after which said IVT-mRNA's are directed to ribosomes and translated into corresponding targeted proteins to reveal their therapeutic effect. Delivery platform produced with said method and its use.
IPC 8 full level
A61K 38/00 (2006.01); A61K 47/51 (2017.01)
CPC (source: EP GR)
A61K 47/64 (2017.07 - EP GR); A61K 48/0025 (2013.01 - GR); A61K 48/0091 (2013.01 - EP); C07K 7/06 (2013.01 - GR); C12N 15/87 (2013.01 - EP); A61K 38/00 (2013.01 - EP); Y02A 50/30 (2017.12 - EP)
Citation (search report)
See references of WO 2021094792A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2021094792 A1 20210520; EP 4061393 A1 20220928; GR 1010063 B 20210820; GR 20190100504 A 20210614
DOCDB simple family (application)
GR 2020000059 W 20201111; EP 20823912 A 20201111; GR 20190100504 A 20191111