EP 4090686 A2 20221123 - PRO-ANTIBODY THAT REDUCES OFF-TARGET TOXICITY
Title (en)
PRO-ANTIBODY THAT REDUCES OFF-TARGET TOXICITY
Title (de)
PRO-ANTIKÖRPER, DER DIE OFF-TARGET-TOXIZITÄT REDUZIERT
Title (fr)
PRO-ANTICORPS RÉDUISANT LA TOXICITÉ HORS CIBLE
Publication
Application
Priority
- US 202062962555 P 20200117
- US 2021013688 W 20210115
Abstract (en)
[origin: CN114945597A] The present invention includes proteins, nucleic acids, and methods of making and using activatable antibodies (aAb) comprising, in order: a first light chain comprising a first light chain variable region; a cuttable joint; a first heavy chain comprising a first heavy chain variable region; wherein the cleavable linker prevents or reduces the formation of a first antigen binding site for the first antigen by the first light chain and the first heavy chain; and wherein cleavage of the cleavable linker releases the first heavy chain to effect formation of a first antigen binding site to bind a first antigen.
IPC 8 full level
C07K 16/30 (2006.01); A61P 17/06 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); G01N 33/58 (2006.01)
CPC (source: EP)
C07K 16/00 (2013.01); C07K 16/28 (2013.01); C07K 16/2809 (2013.01); C07K 16/2818 (2013.01); C07K 16/30 (2013.01); C07K 16/46 (2013.01); C07K 2317/31 (2013.01); C07K 2317/60 (2013.01); C07K 2317/70 (2013.01); C07K 2319/00 (2013.01); C07K 2319/50 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
CN 114945597 A 20220826; EP 4090686 A2 20221123; EP 4090686 A4 20240327
DOCDB simple family (application)
CN 202180009547 A 20210115; EP 21741991 A 20210115