EP 4110265 A1 20230104 - LIPOPHILIC EYE CONTOUR GEL AND METHOD FOR THE PREPARATION THEREOF
Title (en)
LIPOPHILIC EYE CONTOUR GEL AND METHOD FOR THE PREPARATION THEREOF
Title (de)
LIPOPHILES AUGENKONTURGEL UND VERFAHREN ZU SEINER HERSTELLUNG
Title (fr)
GEL DE CONTOUR DES YEUX ET SON PROCÉDÉ DE PRÉPARATION
Publication
Application
Priority
- IT 202000011365 A 20200518
- IB 2021054209 W 20210517
Abstract (en)
[origin: WO2021234536A1] A lipophilic composition for an eye contour gel, with a soothing and cleansing action on the eyelid waterline and the periocular area indicated for the treatment of blepharitis or similar diseases, comprises: liposomes with a particle size less than one micron, or even less than 200 nm, consisting of non-hydrogenated phospholipids which carry Vitamin A Palmitate, Bisabolol, Tea Tree oil and Vitamin E TPGS, Xanthan gum as a viscosifying, gelling and structuring agent with good wetting capacity, and Ferulic acid which, specifically intercalated in the liposomes, protects Vitamin A Palmitate from degradation. By adding Vitamin E TPGS in the liposome preparation step, Vitamin E is inserted into the phospholipid multilayer, while the hydrophilic part thereof, PEG, remains outside the liposomes. This allows the liposomal structure to increase the ability to coordinate water, since the liposomes with PEG chains outside the structure thereof act as "traps" (WHC, Water Holding Capacity) or as "binders" (WBC, Water Binding Capacity).
IPC 8 full level
A61K 8/04 (2006.01); A61K 8/03 (2006.01); A61K 8/14 (2006.01); A61K 8/34 (2006.01); A61K 8/55 (2006.01); A61K 8/67 (2006.01); A61K 8/92 (2006.01); A61P 17/00 (2006.01); A61Q 1/14 (2006.01); A61Q 19/00 (2006.01)
CPC (source: EP)
A61K 8/03 (2013.01); A61K 8/042 (2013.01); A61K 8/14 (2013.01); A61K 8/34 (2013.01); A61K 8/553 (2013.01); A61K 8/67 (2013.01); A61K 8/671 (2013.01); A61K 8/678 (2013.01); A61K 8/922 (2013.01); A61P 17/00 (2017.12); A61Q 1/14 (2013.01); A61Q 19/005 (2013.01)
Citation (search report)
See references of WO 2021234536A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
DOCDB simple family (application)
IB 2021054209 W 20210517; EP 21732115 A 20210517