EP 4288529 A2 20231213 - SYNTHETIC DEGRADER SYSTEM FOR TARGETED PROTEIN DEGRADATION
Title (en)
SYNTHETIC DEGRADER SYSTEM FOR TARGETED PROTEIN DEGRADATION
Title (de)
SYNTHETISCHES ABBAUSYSTEM FÜR GEZIELTEN PROTEINABBAU
Title (fr)
SYSTÈME DE DÉGRADATION SYNTHÉTIQUE POUR LA DÉGRADATION CIBLÉE DE PROTÉINES
Publication
Application
Priority
- US 202163144895 P 20210202
- US 202163248516 P 20210926
- US 2022014998 W 20220202
Abstract (en)
[origin: WO2022169913A2] A fusion protein is provided having a binding element and a degradation initiator, where the binding element selectively binds a target molecule, and the degradation initiator has a sequence isolated or derived from an E3 ligase. A composition is provided comprising: (a) a first fusion protein comprising a first binding element; and (b) a second fusion protein comprising a second binding element; wherein: (1) the first fusion protein further comprises a degradation initiator or a functional variant thereof and the second fusion protein further comprises a target molecule; or (2) the first fusion protein further comprises a target molecule and the second fusion protein further comprises a degradation initiator or a functional variant thereof. The fusion proteins and compositions may be used for the targeted degradation of endogenous and exogenous proteins, optionally, in a cell or in vivo, for the treatment or prevention of a disease or disorder.
IPC 8 full level
C12N 9/10 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C12N 15/52 (2006.01); C12N 15/62 (2006.01)
CPC (source: EP)
A61P 35/00 (2018.01); C07K 14/705 (2013.01); C07K 14/7051 (2013.01); C12N 9/104 (2013.01); C12N 15/62 (2013.01); C12Y 203/02 (2013.01); C07K 14/70521 (2013.01); C07K 2319/00 (2013.01); C07K 2319/01 (2013.01); C07K 2319/81 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022169913 A2 20220811; WO 2022169913 A3 20220929; EP 4288529 A2 20231213; TW 202246309 A 20221201
DOCDB simple family (application)
US 2022014998 W 20220202; EP 22710773 A 20220202; TW 111104424 A 20220207