EP 4319827 A1 20240214 - MARINE SCAFFOLDS FOR HUMAN TISSUE GENERATION
Title (en)
MARINE SCAFFOLDS FOR HUMAN TISSUE GENERATION
Title (de)
MEERESGERÜSTE ZUR ERZEUGUNG VON MENSCHLICHEM GEWEBE
Title (fr)
ÉCHAFAUDAGES MARINS POUR LA GÉNÉRATION DE TISSU HUMAIN
Publication
Application
Priority
- EP 21167738 A 20210409
- EP 2022059530 W 20220408
Abstract (en)
[origin: EP4070824A1] The present invention relates to a method for generation of personalized tissue-engineered human grafts. The method comprising the following steps in the order named: a) providing a body part taken from a marine invertebrate, the body part comprising at least two biologically interconnected tissues selected from the group consisting of connective tissue, muscle tissue, epithelia tissue, and nervous system tissue; b) washing the body part with distilled water; c) decellularizing the washed body part to remove cells and DNA, to provide a decellularized 3D-scaffold with extracellular matrix (ECM) proteins, and, optionally, d) recellularizing the decellularized 3D-scaffold by: inoculating human stem cells into the decellularized 3D-scaffold, and in vitro culturing the human stem cells in the inoculated 3D-scaffold.
IPC 8 full level
A61L 27/36 (2006.01); A61L 27/38 (2006.01); B33Y 70/00 (2020.01)
CPC (source: EP)
A61L 27/3604 (2013.01); A61L 27/3683 (2013.01); A61L 27/3834 (2013.01); A61L 27/3847 (2013.01); A61L 27/3852 (2013.01); B33Y 70/00 (2014.12); A61L 2430/02 (2013.01); A61L 2430/06 (2013.01); A61L 2430/40 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
EP 4070824 A1 20221012; EP 4319827 A1 20240214; WO 2022214693 A1 20221013
DOCDB simple family (application)
EP 21167738 A 20210409; EP 2022059530 W 20220408; EP 22721770 A 20220408