EP 4363577 A1 20240508 - COMPOSITIONS AND METHODS FOR TREATING CANCER
Title (en)
COMPOSITIONS AND METHODS FOR TREATING CANCER
Title (de)
ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON KREBS
Title (fr)
COMPOSITIONS ET MÉTHODES POUR TRAITER LE CANCER
Publication
Application
Priority
- US 202117359905 A 20210628
- US 2022013908 W 20220126
Abstract (en)
[origin: WO2023277959A1] A double stranded RNA interference (RNAi) agent comprising at least one of (i) a first double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a CD320 gene wherein the first dsRNA comprises a sense strand and an antisense strand forming a duplex, (ii) a second dsRNA for inhibiting the expression of a LRP2 gene wherein the second dsRNA comprises a sense strand and an antisense strand forming a duplex, or (iii) a cocktail of (i) and (ii) and wherein the sense strand of the first dsRNA is at least substantially complementary to the antisense strand of the first dsRNA and the sense strand of the second dsRNA is at least substantially complementary to the antisense strand of the second dsRNA and the use of the RNAi agent as a pharmaceutical composition for the treatment of cancer in subjects in need of treatment.
IPC 8 full level
C12N 15/11 (2006.01); A61K 31/713 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); C12N 15/113 (2010.01)
CPC (source: EP)
A61P 35/00 (2017.12); A61P 35/02 (2017.12); C12N 15/1138 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2320/11 (2013.01); C12N 2320/31 (2013.01)
C-Set (source: EP)
Citation (search report)
See references of WO 2023277959A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2023277959 A1 20230105; CA 3174172 A1 20230726; CN 117897482 A 20240416; EP 4363577 A1 20240508
DOCDB simple family (application)
US 2022013908 W 20220126; CA 3174172 A 20220126; CN 202280058799 A 20220126; EP 22833827 A 20220126